DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brv2 and pkd1l2

DIOPT Version :9

Sequence 1:	NP_648970.2	Gene:	brv2 / 39932	FlyBaseID:	FBgn0036712	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	XP_031756633.1	Gene:	pkd1l2 / 100486136	XenbaseID:	XB-GENE-968335	Length:	2458	Species:	Xenopus tropicalis

Alignment Length:	724	Identity:	151/724 - (20%)
Similarity:	269/724 - (37%)	Gaps:	162/724 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NLSSISRKDLTCFGVTTCVVMVCFVLVSIFSGFMHEPQRFKTM--------------LVTIVLVF 52
            :||...:|:..  |:....|.:.::||:..||.    ..|.||              |:::.:.|
Frog  1807 SLSEDGKKNTR--GLPWWFVFIGWLLVAATSGV----SAFFTMLYGLHYGKDSSIKWLISMAISF 1865

  Fly    53 FFQYLILEPIRFFIQSIDYATWPQEDPPYRAEE----------GGPTMDHIGYLKIRLRSLRSEL 107
            |....|.:|::....:..:|...::..|...||          |.|..        .|.|.|...
Frog  1866 FESLFITQPLKVLGFAAFFALVLKKVEPEDEEETTINGNLSTPGDPNP--------LLGSRRDSN 1922

  Fly   108 L--------ISEGHTNEMLNQKYKHIAGDLLLYGSYFIALMLMVVLQEDHTNYYNTNNMQRLFWD 164
            :        |::...|.|..||...:..::|.|..:...|:|:...|.|..:||...:::..|.|
Frog  1923 IYQPPPPTDITKMKNNYMKEQKVFALIREILAYLGFLWMLLLVAYGQRDPNSYYLNKHIESSFTD 1987

  Fly   165 NTSVTFGLSQVYFIYQVHSYMKITLVEAFYAQKTNGYEGWWAMEQWQKIGVVRLRQMRPVDCHIG 229
                  |...:....:..::...||:...|    ..:.|:......:.:|..|:||:|
Frog  1988 ------GFEDLCSYQEFFTWANTTLINNLY----GSHPGFITDGNSKLVGGARMRQIR------- 2035

  Fly   230 LGKPEWDKKTYAP----------EWRLPY----HRMHYTEKFWRIYDPFVPAEFEPSFLNGLLLN 280
                  .||...|          ..|.||    ..|.:.:..|..          .:..|...:|
Frog  2036 ------IKKDSCPVASVLQSTIDNCRAPYSLDAEEMGHYDGSWNF----------SAITNATDVN 2084

  Fly   281 ----YDHYGYLLNYP--------EVAGYVVLMMSTKINCLKQIEYLRDYSWLDKNTSALFIDLTM 333
                |.::..|..:|        ...|||..:.:.:....:.::.|....|||..|.|:|::.|:
Frog  2085 SPWYYQNHSKLRGHPTWGKLATYRGGGYVADLGNERKYAHRVLQDLFSNIWLDSYTRAVFVEFTV 2149

  Fly   334 YNADANLFTLITLRVENSPFGIQLPRVHVDSVSMLGNVETRSNSELLILFVYTVLVILFARGVFT 398
            |||:.|||.::.|..|.:..|....|.::.||.:.      ..::.|.:||....||.|...::.
Frog  2150 YNANVNLFCIVKLMFETNALGTFFTRANLQSVRLY------PFTDGLHIFVVAAEVIYFLFVIYY 2208

  Fly   399 KI----------WHHPAAAHEAWTMVDLAIYI-----LNVFL--TVLAIMRDIETDALLQIIETA 446
            .:          |.:   ....|.:::||:.|     |:|::  |:|. .||:.       ....
Frog  2209 MVVQGKRMKAEKWGY---FRSKWNLLELALIIISWSALSVYVKRTILG-TRDLR-------YYQE 2262

  Fly   447 TKGQYLDFQRPLRLHQMLFIVKGFLVCITTLRLWKVLQFASVFQHFTQTLFSAWRAVASLGVIIL 511
            .|.:::.|.........|..:..|||.::|::||.:|:........|.||..||..::....:|:
Frog  2263 HKNEFVSFNETAAADAALGYLIAFLVLLSTIKLWHLLRLNPKLNMITATLRRAWGDISGFITVIV 2327

  Fly   512 VVLMAIGITLAVPNGNNAVVFSHMVQSVVTCMWYSMG-FNG----DIHPADFFHGGRILGILLYL 571
            ::.:|..|...:..|.....:..:..|..|.:...:| ||.    |.:|        :||..|..
Frog  2328 IMFLAYSIACNLIFGWKLNSYKTVFDSAKTMVSLQLGIFNYEEVLDYNP--------VLGSFLVG 2384

  Fly   572 ALVFLLAIILMNVFASVIYDYFNETSRILKEHSNRSSITFLEFLHVEYADLFGDAFRCLRKTYES 636
            :.:..:..:::|:|.|||...|:|..   |.|........:|.|..:.....|     ||...|.
Frog  2385 SCIIFMTFVVLNLFISVILVAFSEEQ---KHHQASDEEEIVELLLWKICSFLG-----LRHKKEE 2441

  Fly   637 RGHTVAENV 645
            .  :..|||
Frog  2442 A--SAMENV 2448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv2	NP_648970.2	PKD_channel	169..596	CDD:285288	98/474 (21%)
pkd1l2	XP_031756633.1	CLECT	22..147	CDD:214480
		Gal_Lectin	163..243	CDD:396628
		REJ	<615..890	CDD:366875
		GPS	1276..1314	CDD:396408
		PLAT_polycystin	1385..1504	CDD:238850
		PKD_channel	1988..2408	CDD:400395	98/471 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10877
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020