DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment brv2 and pkd1a

DIOPT Version :9

Sequence 1:	NP_648970.2	Gene:	brv2 / 39932	FlyBaseID:	FBgn0036712	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	XP_021333081.1	Gene:	pkd1a / 100149562	ZFINID:	ZDB-GENE-100707-1	Length:	4625	Species:	Danio rerio

Alignment Length:	712	Identity:	132/712 - (18%)
Similarity:	262/712 - (36%)	Gaps:	198/712 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LVTIVLVFFFQYLILEPIRFFIQSIDYATWPQEDPPYRAEEGG-----PTMDHIGYLKIRLRSLR 104
            |::.::.|...:|:|||::..::.:.::...:.   .|.||..     |.::.:.....|:|..:
Zfish  3680 LISCIVSFLSSFLLLEPLKVLLEGVYFSLVVRR---LRPEEQDVLVECPRVERVVQRIPRVRPPQ 3741

  Fly   105 SELLISEGHTNEMLNQKYKHIAGDLLLYGSYFIALMLMVVLQ-----------------EDH--T 150
            ...|.........:...:..:.|.||    |.:.||::::|.                 :||  |
Zfish  3742 GFALSQAREEARKVRLLHTMLKGFLL----YMLFLMVVLLLNYSDSEKDAHRLRLNAQLQDHFLT 3802

  Fly   151 NYYNTNNMQRLFWDNTSVTFGLSQVYFIYQVHSYMKITLVEAFYAQKTNGYEGWWAMEQWQKIGV 215
            .::|..:.:...|              .:..:|.:...|.|....:||...          .||.
Zfish  3803 KHFNNISSREDVW--------------AWLSNSLLPRLLDEQVLMEKTGSL----------LIGR 3843

  Fly   216 VRLRQMRPVDCHIGLGKPEWDKKTYAP--EWRLPYHRMHYTEKFWRIYDPFVPAEFEPSFLNGLL 278
            .||||.|        .:||.....|.|  .|      ....:..|        ||    ..:||:
Zfish  3844 ARLRQTR--------AQPECPVSGYFPASSW------FGCVQAGW--------AE----SASGLV 3882

  Fly   279 LNYD----------HYGYLLNYPEVAGYVVLMMSTKINCLKQ-IEYLRDYSWLDKNTSALFIDLT 332
            .|:.          |:|.:..|.. :|: |..:|.|:...|. |..|..:.|||..|.|||::.:
Zfish  3883 QNWSVSTAQSSGVWHWGQVSVYSS-SGF-VQDLSRKMQDSKNLINQLNTHQWLDPLTRALFLEFS 3945

  Fly   333 MYNADANLFTLITLRVENSPFGI-QLPRVHVDSVSMLGNVETRSNSELLILFVYTVLVILF---- 392
            :||.:.:|.::.:..:|   |.: :..::.:|..:.  ::.|.|:...|.||:..:|::|.
Zfish  3946 LYNINTDLLSVFSFLLE---FPVSERAQLSLDLKTF--SLHTLSHGMDLPLFLTLILLVLLIYFS 4005

  Fly   393 ----------ARGVFTKIWHHPAAAHEAWTMVDLAIYILNVFLTVLAIMRDI----ETDALLQII 443
                      .|..|.::|:          :..:...:|.|.:..|.:.|.:    :..|.||
Zfish  4006 VREGLLVWKQGRCYFLRVWN----------LASVCSLLLAVCVASLHLSRSVVSAQQWRAFLQ-- 4058

  Fly   444 ETATKGQYLDFQRPLRLHQMLFIVKGFLVCITTLRLWKVLQFASVFQHFTQTLFSAWRAVASLGV 508
               .:..:.||....:.:|:|..:...|:.:..|:....|:|...:..|.:||..::..:..:.|
Zfish  4059 ---HRDAFTDFFPLAQQNQLLTQMSATLLFLLVLKASHQLRFLREWGVFGRTLRKSFWELLMVAV 4120

  Fly   509 IILVVLMAIGITLAVPNGNNAVVFSH----MVQSVVTCMWYSMGFNGDIHPADFFHGGRILG--- 566
            .:||.|:|               :||    :..||:.      |: |.:....|    :::|
Zfish  4121 TLLVFLLA---------------YSHTGHLLFHSVME------GY-GTVSSTCF----KLIGSSG 4159

  Fly   567 -------------------ILLYLALVFLLAIILMNVFASVIYDYFNETSRILKEHSNRSSITFL 612
                               .:.|::...|..::|..:.::::.:|     |..:....|.::...
Zfish  4160 RGLLSWRPDSGSFPCSGSCFIFYISFTLLRLVLLWILMSALLRNY-----RRARAELYRPAVDLQ 4219

  Fly   613 EFLHVEYADLFGDAFRC---LRKTYESRGHTVAENVELELNRRELIKFKRDLIKSPQELKRA 671
            ::   |..:||....:.   |.:|.|.|.....|.:||..:|.......:.|...|.:...|
Zfish  4220 DY---EMVELFLRRLKMWMGLSRTKEFRHKVRFEGMELPPSRSSSTSDCKSLCLPPLDTPEA 4278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv2	NP_648970.2	PKD_channel	169..596	CDD:285288	91/484 (19%)
pkd1a	XP_021333081.1	LRR	<68..>167	CDD:227223
		leucine-rich repeat	88..110	CDD:275378
		leucine-rich repeat	111..133	CDD:275378
		leucine-rich repeat	134..157	CDD:275378
		PCC	138..2795	CDD:188093
		leucine-rich repeat	158..170	CDD:275378
		GPS	3106..3155	CDD:197639
		PLAT	3213..3326	CDD:320707
		PKD_channel	3802..4155	CDD:332708	89/450 (20%)
		Atrophin-1	4496..>4606	CDD:331285
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820