DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LLGL2 and SRO77

DIOPT Version :9

Sequence 1:	XP_011523104.1	Gene:	LLGL2 / 3993	HGNCID:	6629	Length:	1024	Species:	Homo sapiens
Sequence 2:	NP_009444.2	Gene:	SRO77 / 852168	SGDID:	S000000202	Length:	1010	Species:	Saccharomyces cerevisiae

Alignment Length:	1003	Identity:	199/1003 - (19%)
Similarity:	333/1003 - (33%)	Gaps:	325/1003 - (32%)

- Green bases have known domain annotations that are detailed below.

Human     9 HDPVRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQEN 73
            || |...:....|...|...:|...:.:...:..:..:||:.|.:|.|.:||...:|.:...:..
Yeast    21 HD-VSNGINSKFFDTKKICTYGINGRITVTTFDYTQSLLAVATTAGEIHVYGQKQIEVVFTLKNR 84

Human    74 NAVTQIHLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQI--TVVL 136
            ..:..:..:.| ..|:.:.:.:::.:.|:..|                         ||  ||..
Yeast    85 PQIKHMRFIKG-IYLIAVDEKSNIIVLSVHSK-------------------------QILTTVFC 123

Human   137 PHS--------SCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQR------LPEEARHRRV 187
            |:|        |.:.:.:|.|||::.:..:       ||...|...::.      ||:|.
Yeast   124 PNSITCIETDPSLDWMLIGLESGSILIYDV-------DRNQMSKLKIENFQKSVFLPKER----- 176

Human   188 FEMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLE----------NIWWQRDG 242
            ...|.::|.:|||...|||.|.. :.||:.....:|..||.  .|||          ||..:|..
Yeast   177 LSPVISIQWNPRDIGTILISYEH-ITVIYSFIDYKVKQHFF--YQLEPYAPGGDLSTNIEKKRTP 238

Human   243 RL-----------LVSCHSDGSYCQWPVSS------------EAQQPEPLRSLVPYGPFPCKAIT 284
            ::           :::.|.|.|...|.|:|            ....|.|......:...|  ||.
Yeast   239 KVIQSLYHPNSLHILTVHEDNSLVFWDVNSGKLIHARSIFETHVNFPNPALKDCSFTETP--AIF 301

Human   285 RILWLTTRQG----------------LPFTIFQ---GGMPRASYGDRHCISVIH--DGQQTAFDF 328
            ::.||..|..                ||..|..   ||.|..|......:|..:  ..||..|..
Yeast   302 KVSWLCQRNPEYTSLLIATKATENPCLPQEITMIDLGGTPMYSVTSFDAMSKYYAKPVQQKLFSL 366

Human   329 TSR--VIGFTVLTEADP--AATFDDPYALVVLAEEELVVIDLQTAGWPPVQLPYLASLHCSAITC 389
            ..:  :|.|..|.:|.|  ....|....|::|.:.|     |:|..:|             |.:.
Yeast   367 IGKAPLINFLPLPKASPYFGGCHDTNLILLLLEDGE-----LETLIYP-------------AGSF 413

Human   390 SHHVSNIPLKL-WER-----IIAAGSRQNAHFSTM-----EWPIDGGTSLT---PAPPQRDLLLT 440
            |...|..|..| |.|     .||...::|.....|     |..:.||...|   .....|..|||
Yeast   414 SSKASIFPRSLAWVRPTVTTCIAQSVQKNLWLGMMTIAQSESFLKGGIPATRNIRRHETRSALLT 478

Human   441 GHEDGTVRFWDA--SGVCLRLLYKLSTVRVFLTDTDPNENFSAQGEDEWPPLRKVGSFDPYSDDP 503
            ||.:|:||.|||  |.|....:::::|.:|....|:
Yeast   479 GHSNGSVRIWDASHSEVTDNAVFEVNTAKVLNRATN----------------------------- 514

Human   504 RLGIQKIFLCKYSGYLAVAGTAGQVLVLEL----------NDEAAEQAVEQVEAD----LLQDQE 554
             |.|:.|.....:..|||:...|.|::.:.          ..:|.:....:...|    :|.|
Yeast   515 -LAIKNISFASETLELAVSSEVGDVILFKFETNKFYGQLPKSDALQLKFSRFSLDDSKTILVD-- 576

Human   555 GYRWKGHERLAARSGPVRFEPGFQPFVLVQCQPPAVVTSLALHSEWRLVAFGTSHGFGLFDHQQR 619
                      .:..||...:.||.|..::..:..||  |..::|....||.|
Yeast   577 ----------VSDRGPTNVKQGFIPSTVIHAKKGAV--SAIMNSNIGFVAVG------------- 616

Human   620 RQVFVKCTLHPSDQLALEGPLSRVKSLKKSLRQSFRRMRRSRVSSRKRHPAGPPGE-VRPEAQEG 683
               |::.||...|                                 :|.||....| :|..::.|
Yeast   617 ---FIEGTLIILD---------------------------------RRGPAIIFNENIRVISKAG 645

Human   684 SAKAERPGLQNMELAPVQRKIEARSAEDSFTGFVRTLYFADTYLKDSSRHCPSLWAGTNGGTIYA 748
            |:                              :|.|::|......|.......:..||:.|.:..
Yeast   646 SS------------------------------YVSTVHFCVMEYGDDGFSSILMLCGTDIGELMT 680

Human   749 FSLRVPPAERRMDEPVRAEQAKEIQLMHRAPVVGI--LVLD-GHSVPLPEPLEVAHDLSKS---- 806
            |.: :|....|.:  |:...|.:..  ::..::||  ...| |:|  ....:.....|||.
Yeast   681 FKI-LPATNGRFE--VKFTDATKTN--NQGKILGINSFAKDTGYS--CSATISKMQGLSKGIAIP 738

Human   807 --PDMQGSHQLLVVSEEQFK----VFTLPKVSAKLKLKLTALEGSRVRRVSVAHFGSRRAEDYGE 865
              ..:.|::.:.:||..:.|    :|..|..::.|.. :..::|...|::|..
Yeast   739 GFVTISGANDIRLVSPGKSKDTHALFKYPIATSGLSF-IPIIDGKGERKLSTI------------ 790

Human   866 HHLAVLTNLGDIQVVSLPLLKPQVRYSC 893
              :.||...|||:|:::|.||......|
Yeast   791 --MIVLLINGDIKVLTVPELKEVKNLRC 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LLGL2	XP_011523104.1	WD40 repeat	36..72	CDD:293791	8/35 (23%)
		WD40	<40..262	CDD:225201	55/270 (20%)
		WD40 repeat	77..111	CDD:293791	4/33 (12%)
		WD40 repeat	116..157	CDD:293791	11/50 (22%)
		WD40 repeat	191..228	CDD:293791	13/36 (36%)
		WD40 repeat	236..273	CDD:293791	10/59 (17%)
		LLGL	271..371	CDD:369834	28/124 (23%)
SRO77	NP_009444.2	WD40_like	<48..>151	CDD:407205	23/128 (18%)
		WD40 repeat	88..122	CDD:293791	7/59 (12%)
		WD40 repeat	127..167	CDD:293791	8/46 (17%)
		WD40 repeat	180..233	CDD:293791	18/55 (33%)
		WD40 repeat	240..264	CDD:293791	3/23 (13%)
		Lgl_C	514..916	CDD:400768	75/448 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C159051072
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1983
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10241
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840