DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LLGL2 and llgl2

DIOPT Version :9

Sequence 1:	XP_011523104.1	Gene:	LLGL2 / 3993	HGNCID:	6629	Length:	1024	Species:	Homo sapiens
Sequence 2:	NP_997747.1	Gene:	llgl2 / 795670	ZFINID:	ZDB-GENE-030131-9877	Length:	1020	Species:	Danio rerio

Alignment Length:	1032	Identity:	680/1032 - (65%)
Similarity:	789/1032 - (76%)	Gaps:	24/1032 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MRRFLRPGHDPVRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVE 65
            |:||.|.||:..|::.|:||:||||||||||||||||||:||||.:|||||||||||||||||||
Zfish     1 MKRFRRHGHESQRDKHKQDLYQFNKTVEHGFPHQPSALGFSPSLELLAIGTRSGAIKLYGAPGVE 65

Human    66 FMGLHQENNAVTQIHLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSAT 130
            |||||.||.||||:|.||.|.:|||||:|||||:|:|:......||.|...|||.|||||.||.|
Zfish    66 FMGLHDENAAVTQVHFLPNQVELVTLLEDNSLHMWTLRAHNSMCELLEIGRFTLSGPPGAIPSVT 130

Human   131 QITVVLPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEMVEALQ 195
            ::|.||.|||.|||.||||.|:||||::|.||.||:..||.:.|..|:||:...||..|.||.|.
Zfish   131 RVTAVLAHSSGELLLLGTEGGHVFVVEVPGFRELEENNISVEDVQNRVPEDYVGRRNLESVETLH 195

Human   196 EHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIWWQRDGRLLVSCHSDGSYCQWPVS 260
            |:|.:|.|:||||||||:|:|||...|.:.|||.:||||::||..||..::|.|||||||||.|:
Zfish   196 ENPLNPRQVLIGYSRGLMVLWDLDRQRPVQHFLGTQQLESVWWMEDGESILSSHSDGSYCQWTVT 260

Human   261 SEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGDRHCISVIHDGQQTA 325
            .|..|.||.:...|||.||||||::|:.|.::||.||.||.||||||||||||||||||.....|
Zfish   261 GEDPQTEPEKQETPYGAFPCKAISKIIQLPSKQGPPFLIFSGGMPRASYGDRHCISVIHSKTHEA 325

Human   326 FDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEELVVIDLQTAGWPPVQLPYLASLHCSAITCS 390
            .|||||:|.|.|:.|.:...  .:|.|||||.||||||:||||.|||.:|.|||..|||||||||
Zfish   326 LDFTSRIIDFFVIREGENHK--GEPSALVVLVEEELVVVDLQTEGWPVIQTPYLVPLHCSAITCS 388

Human   391 HHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDLLLTGHEDGTVRFWDASGV 455
            ||||:||||||||:.|||:.||.|:|...|||:||.:|.|.||||||||||||||||||||||||
Zfish   389 HHVSSIPLKLWERVQAAGAHQNTHYSRKPWPINGGKNLAPDPPQRDLLLTGHEDGTVRFWDASGV 453

Human   456 CLRLLYKLSTVRVFLTDTDPNENFSAQGEDEWPPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLA 520
            ||..:|||||..||.||.|||:|.:...|.||||.||||.|||||||||||||||.||||||||.
Zfish   454 CLYPMYKLSTAGVFHTDADPNDNMNQGSEGEWPPFRKVGCFDPYSDDPRLGIQKIHLCKYSGYLT 518

Human   521 VAGTAGQVLVLELNDEAAEQAVEQVEADLLQDQEGYRWKGHERLAARSGPVRFEPGFQPFVLVQC 585
            |||||||:||||||||||||.||....||||.|||:||||..||..|..||.|.||||||.||||
Zfish   519 VAGTAGQILVLELNDEAAEQMVEATVVDLLQGQEGFRWKGQARLDVREEPVLFPPGFQPFALVQC 583

Human   586 QPPAVVTSLALHSEWRLVAFGTSHGFGLFDHQQRRQVFVKCTLHPSDQLALEGPLSRVKSLKKSL 650
            |||||||::||||||:||.|||||||||:|:.||..:.|||||:||||:|:|||||||||:||||
Zfish   584 QPPAVVTAIALHSEWKLVGFGTSHGFGLYDYNQRNNIMVKCTLNPSDQMAMEGPLSRVKSIKKSL 648

Human   651 RQSFRRMRRSRVSSRKRHPAGPPGEVRPEAQEGSAKAERPGLQNMELAPVQRKIEARSAEDSFTG 715
            ||||||:||||||.||.|...     ..:.||.:|:.|...||.||||||||||||||::|||||
Zfish   649 RQSFRRIRRSRVSMRKHHTNN-----AAKLQEINARLEAEALQEMELAPVQRKIEARSSDDSFTG 708

Human   716 FVRTLYFADTYLKDSSRHCPSLWAGTNGGTIYAFSLRVPPAERRMDEPVRAEQAKEIQLMHRAPV 780
            .|||||||||::.|||...||||||||||.::|:.|||||.|||.::||.|..||||||||||||
Zfish   709 LVRTLYFADTFVSDSSHSTPSLWAGTNGGAVFAYVLRVPPQERRAEDPVTAHAAKEIQLMHRAPV 773

Human   781 VGILVLDGHSVPLPEPLEVAHDLSKSPDMQGSHQLLVVSEEQFKVFTLPKVSAKLKLKLTALEGS 845
            ||::||||...||||||||||||::||:|.|||.||||||||||:|||||||:|.||||||::||
Zfish   774 VGLVVLDGKGAPLPEPLEVAHDLARSPEMHGSHHLLVVSEEQFKLFTLPKVSSKSKLKLTAVDGS 838

Human   846 RVRRVSVAHFGSRRAEDYGEHHLAVLTNLGDIQVVSLPLLKPQVRYSCIRREDVSGIASCVFTKY 910
            |||||.||.||||..|.. |..|.||||.|::.|:|||.:|..|.|.||||||||||||||||||
Zfish   839 RVRRVGVAWFGSRTDEQL-ESCLVVLTNQGELHVISLPSIKMLVHYPCIRREDVSGIASCVFTKY 902

Human   911 GQGFYLISPSEFERFSLSTKWLVEPRCLVD--------SAETKNHRPGNGAGPKKAPSRARNSGT 967
            |||||||||||||||||||:|:|:|.|||:        |..:..||.    .|...|:..||...
Zfish   903 GQGFYLISPSEFERFSLSTRWVVQPHCLVEPPLQMRSKSPSSPVHRD----LPDGVPTEHRNFKG 963

Human   968 QSDGEEKQPGLVMERALLSDERVLKEIQSTLEGDRGS---GNWRSHRAAVGCSLSNG 1021
            .|:|.|.....|||.|||:||.||:|||.:||||:.:   .|.:: :...|..||||
Zfish   964 DSEGYENSARQVMEHALLNDESVLQEIQKSLEGDQTTFLENNLKT-KPKAGNVLSNG 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LLGL2	XP_011523104.1	WD40 repeat	36..72	CDD:293791	32/35 (91%)
		WD40	<40..262	CDD:225201	138/221 (62%)
		WD40 repeat	77..111	CDD:293791	18/33 (55%)
		WD40 repeat	116..157	CDD:293791	28/40 (70%)
		WD40 repeat	191..228	CDD:293791	21/36 (58%)
		WD40 repeat	236..273	CDD:293791	19/36 (53%)
		LLGL	271..371	CDD:369834	61/99 (62%)
llgl2	NP_997747.1	WD40	<29..253	CDD:392136	142/223 (64%)
		WD40 repeat	36..72	CDD:293791	32/35 (91%)
		WD 1	36..69		29/32 (91%)
		WD 2	76..117		22/40 (55%)
		WD40 repeat	77..119	CDD:293791	22/41 (54%)
		WD40 repeat	132..176	CDD:293791	26/43 (60%)
		WD 3	132..169		23/36 (64%)
		WD40 repeat	189..228	CDD:293791	22/38 (58%)
		WD 4	193..227		18/33 (55%)
		WD40 repeat	233..273	CDD:293791	21/39 (54%)
		WD 5	233..264		18/30 (60%)
		LLGL	273..369	CDD:369834	61/97 (63%)
		WD 6	282..324		28/41 (68%)
		WD 7	332..364		16/33 (48%)
		WD 8	386..462		57/75 (76%)
		WD 9	506..581		55/74 (74%)
		WD 10	590..651		45/60 (75%)
		WD 11	710..766		37/55 (67%)
		WD 12	775..827		40/51 (78%)
		WD 13	832..884		30/52 (58%)
		WD 14	898..921		22/22 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	935..968		8/36 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194339494
Domainoid	1	1.000	745	1.000	Domainoid score	I966
eggNOG	1	0.900	-	-		E1_KOG1983
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3323
Inparanoid	1	1.050	1352	1.000	Inparanoid score	I1229
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48039
OrthoDB	1	1.010	-	-		D113391at33208
OrthoFinder	1	1.000	-	-		FOG0000702
OrthoInspector	1	1.000	-	-		oto48032
orthoMCL	1	0.900	-	-		OOG6_104800
Panther	1	1.100	-	-	LDO	PTHR10241
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6137
SonicParanoid	1	1.000	-	-		X453
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.300