DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LLGL2 and llgl2

DIOPT Version :9

Sequence 1:	XP_011523104.1	Gene:	LLGL2 / 3993	HGNCID:	6629	Length:	1024	Species:	Homo sapiens
Sequence 2:	NP_001015691.1	Gene:	llgl2 / 548396	XenbaseID:	XB-GENE-868478	Length:	1019	Species:	Xenopus tropicalis

Alignment Length:	1027	Identity:	726/1027 - (70%)
Similarity:	843/1027 - (82%)	Gaps:	11/1027 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MRRFLRPGHDPVRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVE 65
            |:||||.|||.||||||||||||||||||||||||||||||..|.::||||||||:|:||:||||
Frog     1 MKRFLRSGHDSVRERLKRDLFQFNKTVEHGFPHQPSALGYSDCLSLMAIGTRSGALKVYGSPGVE 65

Human    66 FMGLHQENNAVTQIHLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSAT 130
            |||||.|||:||:|..:|.||||||:||||||||||.....|.|||||::.||||||||:.||.|
Frog    66 FMGLHDENNSVTKISFIPDQCQLVTVLDDNSLHLWSFPHHDGVSELQEEKKFTLRGPPGSPPSVT 130

Human   131 QITVVLPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEMVEALQ 195
            ||.|:|||||.|.||:|||.|:||:::||:.|.||::|:..:|.||.||:|...||.||.|||||
Frog   131 QIKVLLPHSSGEKLYVGTEGGSVFILELPSLRVLEEKTVGHEAALQGLPDEYSSRRAFESVEALQ 195

Human   196 EHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIWWQRDGRLLVSCHSDGSYCQWPVS 260
            |:||:|:|:|||||||::|.|||...|.:.:||..|||||::|.|||:.:|||||||.|.||.||
Frog   196 ENPRNPDQLLIGYSRGMMVTWDLVKGRSVQYFLGKQQLENVFWCRDGKQIVSCHSDGGYNQWEVS 260

Human   261 SEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQG-LPFTIFQGGMPRASYGDRHCISVIHDGQQT 324
            :|..|..|..|.||||||.||||::|.|.|||:. .|:.:||||||.|||||||.|||:|..|||
Frog   261 NELVQVSPKESKVPYGPFRCKAISKITWHTTRRSRSPYVVFQGGMPMASYGDRHIISVVHGNQQT 325

Human   325 AFDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEELVVIDLQTAGWPPVQLPYLASLHCSAITC 389
            |||||||:|...|:...||:|.:|||.||:||.|||||:||||:.|||.:|.|||.|||||||||
Frog   326 AFDFTSRIIDHVVIANPDPSAEYDDPRALLVLVEEELVMIDLQSPGWPVIQCPYLISLHCSAITC 390

Human   390 SHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDLLLTGHEDGTVRFWDASG 454
            |||:|:||||||||||:||.:||..:|.|.||||||.:|.|||.|||||||||||||||||||||
Frog   391 SHHISSIPLKLWERIISAGRKQNTQYSNMPWPIDGGVNLAPAPFQRDLLLTGHEDGTVRFWDASG 455

Human   455 VCLRLLYKLSTVRVFLTDTDPNENFSAQGEDEWPPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYL 519
            :||:|:||:|||.||.|::|.|:|.::..|:|||||||||||||||||||||||||::|||||||
Frog   456 ICLQLMYKMSTVSVFQTESDHNDNVNSNEEEEWPPLRKVGSFDPYSDDPRLGIQKIYMCKYSGYL 520

Human   520 AVAGTAGQVLVLELNDEAAEQAVEQVEADLLQDQEGYRWKGHERLAARSGPVRFEPGFQPFVLVQ 584
            :||||||||||:||||||||..|::...||||:|||||||||:||.||..||||.||||||.|||
Frog   521 SVAGTAGQVLVMELNDEAAEHVVDETLVDLLQEQEGYRWKGHKRLHAREDPVRFPPGFQPFALVQ 585

Human   585 CQPPAVVTSLALHSEWRLVAFGTSHGFGLFDHQQRRQVFVKCTLHPSDQLALEGPLSRVKSLKKS 649
            |||||.||||||||||||:||||||||||:|.||:|||..|||||.|||:|||||||||||||||
Frog   586 CQPPAAVTSLALHSEWRLLAFGTSHGFGLYDFQQKRQVMAKCTLHASDQMALEGPLSRVKSLKKS 650

Human   650 LRQSFRRMRRSRVSSRKRHPAGPPGEVRPEAQEGSAKAERPGLQNMELAPVQRKIEARSAEDSFT 714
            |||||||:|||:|:.|:      ||..|  .||.:|:.|:..||.||||||||:|||||||||||
Frog   651 LRQSFRRIRRSQVNKRR------PGPDR--VQEANARFEQEALQEMELAPVQRRIEARSAEDSFT 707

Human   715 GFVRTLYFADTYLKDSSRHCPSLWAGTNGGTIYAFSLRVPPAERRMDEPVRAEQAKEIQLMHRAP 779
            |||||||||||||:|||||.|||||||||||:|||||||||.||||:|.|.|.||||||||||||
Frog   708 GFVRTLYFADTYLRDSSRHTPSLWAGTNGGTVYAFSLRVPPTERRMEEAVAATQAKEIQLMHRAP 772

Human   780 VVGILVLDGHSVPLPEPLEVAHDLSKSPDMQGSHQLLVVSEEQFKVFTLPKVSAKLKLKLTALEG 844
            |||||||||||||||||||.||||||||||||||||||.||||||||||||||:||||||||.:|
Frog   773 VVGILVLDGHSVPLPEPLEAAHDLSKSPDMQGSHQLLVTSEEQFKVFTLPKVSSKLKLKLTATDG 837

Human   845 SRVRRVSVAHFGSRRAEDYGEHHLAVLTNLGDIQVVSLPLLKPQVRYSCIRREDVSGIASCVFTK 909
            .|||:::|..:||.::|::.|:||.:|||||||||||||.|||||||.|||:|||||||||||||
Frog   838 CRVRKMTVCTYGSCKSEEHSENHLTILTNLGDIQVVSLPHLKPQVRYDCIRKEDVSGIASCVFTK 902

Human   910 YGQGFYLISPSEFERFSLSTKWLVEPRCLVDSAE-TKNHRPGNGAGPKKAPSRARNSGTQSDGEE 973
            :|.|.....|||.|||||||.|||.||..||..| .:|.|...|....:...|:|:|||...|.:
Frog   903 HGAGVLSNLPSELERFSLSTCWLVAPRARVDPPEPPRNSRLRRGGSTDQPTDRSRSSGTDHTGGQ 967

Human   974 KQPGLVMERALLSDERVLKEIQSTLEGDRGSGNWRSHR-AAVGCSLSNGGAE 1024
            :..|.:||.|||:||::||||||||||.|.|.:.||.| .:||..|.||.||
Frog   968 RAQGTLMEHALLNDEKMLKEIQSTLEGTRISYSERSSRQMSVGHRLINGAAE 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LLGL2	XP_011523104.1	WD40 repeat	36..72	CDD:293791	27/35 (77%)
		WD40	<40..262	CDD:225201	141/221 (64%)
		WD40 repeat	77..111	CDD:293791	21/33 (64%)
		WD40 repeat	116..157	CDD:293791	28/40 (70%)
		WD40 repeat	191..228	CDD:293791	22/36 (61%)
		WD40 repeat	236..273	CDD:293791	20/36 (56%)
		LLGL	271..371	CDD:369834	65/100 (65%)
llgl2	NP_001015691.1	WD40 repeat	36..72	CDD:293791	27/35 (77%)
		WD40	<40..266	CDD:295369	142/225 (63%)
		WD40	<41..264	CDD:225201	141/222 (64%)
		WD40 repeat	77..124	CDD:293791	31/46 (67%)
		WD40 repeat	129..176	CDD:293791	25/46 (54%)
		WD40 repeat	189..228	CDD:293791	23/38 (61%)
		LLGL	272..372	CDD:285555	64/99 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	836	1.000	Domainoid score	I1079
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3323
Inparanoid	1	1.050	1491	1.000	Inparanoid score	I1417
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48039
OrthoDB	1	1.010	-	-		D113391at33208
OrthoFinder	1	1.000	-	-		FOG0000702
OrthoInspector	1	1.000	-	-		oto156383
Panther	1	1.100	-	-	LDO	PTHR10241
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X453
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.080