DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LLGL2 and Llgl2

DIOPT Version :9

Sequence 1:	XP_011523104.1	Gene:	LLGL2 / 3993	HGNCID:	6629	Length:	1024	Species:	Homo sapiens
Sequence 2:	XP_006247786.2	Gene:	Llgl2 / 360661	RGDID:	1560307	Length:	1027	Species:	Rattus norvegicus

Alignment Length:	1029	Identity:	926/1029 - (89%)
Similarity:	957/1029 - (93%)	Gaps:	7/1029 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MRRFLRPGHDPVRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVE 65
            ||||||.||||.|||||||||||||||||||||||||||||||||||||||||||:|||||||||
  Rat     1 MRRFLRTGHDPARERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAVKLYGAPGVE 65

Human    66 FMGLHQENNAVTQIHLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSAT 130
            |||||:|||||.|||.||||||||||||||||||||||||||.|||||:||||||||||||||||
  Rat    66 FMGLHKENNAVLQIHFLPGQCQLVTLLDDNSLHLWSLKVKGGVSELQEEESFTLRGPPGAAPSAT 130

Human   131 QITVVLPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEMVEALQ 195
            |||.:|||||.||||||||||:||||:||.|.||.|||||||.|||.||||||||||||||||||
  Rat   131 QITEILPHSSGELLYLGTESGSVFVVRLPGFCALHDRTISSDEVLQWLPEEARHRRVFEMVEALQ 195

Human   196 EHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIWWQRDGRLLVSCHSDGSYCQWPVS 260
            |||||||||||||||||||||||:.||||.||||.|||||:.|||||.|:|:||||||:|||.|.
  Rat   196 EHPRDPNQILIGYSRGLVVIWDLRASRVLSHFLSHQQLENVSWQRDGCLIVTCHSDGSHCQWSVP 260

Human   261 SEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGDRHCISVIHDGQQTA 325
            |:.|.||||||.||||||||||||:|.||||||||||||||||||||||||||||||:|:|||||
  Rat   261 SDTQSPEPLRSSVPYGPFPCKAITKIFWLTTRQGLPFTIFQGGMPRASYGDRHCISVVHNGQQTA 325

Human   326 FDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEELVVIDLQTAGWPPVQLPYLASLHCSAITCS 390
            ||||||||.||||.||||.|.||||||||||||||||||||||.|||||||||||||||||||||
  Rat   326 FDFTSRVIDFTVLMEADPVAAFDDPYALVVLAEEELVVIDLQTPGWPPVQLPYLASLHCSAITCS 390

Human   391 HHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDLLLTGHEDGTVRFWDASGV 455
            ||||||||||||||||||||||:|||||||||||||||.|.||||||||||||||||||||||||
  Rat   391 HHVSNIPLKLWERIIAAGSRQNSHFSTMEWPIDGGTSLAPPPPQRDLLLTGHEDGTVRFWDASGV 455

Human   456 CLRLLYKLSTVRVFLTDTDPNENFSAQGEDEWPPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLA 520
            |||||||||||||||||||.:||.|||||||||||||||||||||||||||||||||||||||||
  Rat   456 CLRLLYKLSTVRVFLTDTDLSENLSAQGEDEWPPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLA 520

Human   521 VAGTAGQVLVLELNDEAAEQAVEQVEADLLQDQEGYRWKGHERLAARSGPVRFEPGFQPFVLVQC 585
            |||||||||||||||||||.|||||||||||||||||||||||||||.||||||.||||||||||
  Rat   521 VAGTAGQVLVLELNDEAAEHAVEQVEADLLQDQEGYRWKGHERLAARPGPVRFEAGFQPFVLVQC 585

Human   586 QPPAVVTSLALHSEWRLVAFGTSHGFGLFDHQQRRQVFVKCTLHPSDQLALEGPLSRVKSLKKSL 650
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   586 QPPAVVTSLALHSEWRLVAFGTSHGFGLFDHQQRRQVFVKCTLHPSDQLALEGPLSRVKSLKKSL 650

Human   651 RQSFRRMRRSRVSSRKRHPAGPPGEVRPEAQEGSAKAERPGLQNMELAPVQRKIEARSAEDSFTG 715
            |||||||||||.||.||.|.||.||.  :||..:.||||.|||||||||||||||||||||||||
  Rat   651 RQSFRRMRRSRASSHKRRPGGPTGEA--QAQAVNTKAERTGLQNMELAPVQRKIEARSAEDSFTG 713

Human   716 FVRTLYFADTYLKDSSRHCPSLWAGTNGGTIYAFSLRVPPAERRMDEPVRAEQAKEIQLMHRAPV 780
            ||||||||||||:|||||||||||||||||:|||||||||||||.||||||||||||||||||||
  Rat   714 FVRTLYFADTYLRDSSRHCPSLWAGTNGGTVYAFSLRVPPAERRADEPVRAEQAKEIQLMHRAPV 778

Human   781 VGILVLDGHSVPLPEPLEVAHDLSKSPDMQGSHQLLVVSEEQFKVFTLPKVSAKLKLKLTALEGS 845
            |||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   779 VGILVLDGHNVPLPEPLEVAHDLSKSPDMQGSHQLLVVSEEQFKVFTLPKVSAKLKLKLTALEGS 843

Human   846 RVRRVSVAHFGSRRAEDYGEHHLAVLTNLGDIQVVSLPLLKPQVRYSCIRREDVSGIASCVFTKY 910
            |||||.||||||.|||||||||||||||||||||||:||||||||||||||||||||||||||||
  Rat   844 RVRRVGVAHFGSCRAEDYGEHHLAVLTNLGDIQVVSVPLLKPQVRYSCIRREDVSGIASCVFTKY 908

Human   911 GQGFYLISPSEFERFSLSTKWLVEPRCLVDSAETKNH-RP--GNGAGPKKAPSRARNSGTQSDGE 972
            ||||||||||||||||||||||||||||||||:.:|| ||  ||..|||:...:.|||.:||||.
  Rat   909 GQGFYLISPSEFERFSLSTKWLVEPRCLVDSAKARNHNRPSNGNSTGPKRTSGQVRNSRSQSDGA 973

Human   973 EKQPGLVMERALLSD-ERVLKEIQSTLEGDRGS-GNWRSHRAAVGCSLSNGGAE 1024
            |.:||.|||.||||| ..||||:|||||||:|| |||||||.||||.||||.||
  Rat   974 ETKPGPVMEHALLSDASGVLKEVQSTLEGDQGSCGNWRSHRVAVGCRLSNGEAE 1027

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LLGL2	XP_011523104.1	WD40 repeat	36..72	CDD:293791	34/35 (97%)
		WD40	<40..262	CDD:225201	193/221 (87%)
		WD40 repeat	77..111	CDD:293791	30/33 (91%)
		WD40 repeat	116..157	CDD:293791	36/40 (90%)
		WD40 repeat	191..228	CDD:293791	33/36 (92%)
		WD40 repeat	236..273	CDD:293791	25/36 (69%)
		LLGL	271..371	CDD:369834	89/99 (90%)
Llgl2	XP_006247786.2	WD40	<36..267	CDD:225201	199/230 (87%)
		WD40 repeat	36..72	CDD:293791	34/35 (97%)
		WD40 repeat	77..121	CDD:293791	39/43 (91%)
		WD40 repeat	132..189	CDD:293791	46/56 (82%)
		WD40 repeat	192..228	CDD:293791	32/35 (91%)
		LLGL	271..371	CDD:400597	89/99 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83691807
Domainoid	1	1.000	1024	1.000	Domainoid score	I1447
eggNOG	1	0.900	-	-		E1_KOG1983
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3323
Inparanoid	1	1.050	1858	1.000	Inparanoid score	I1716
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48039
OrthoDB	1	1.010	-	-		D10159at314146
OrthoFinder	1	1.000	-	-		FOG0000702
OrthoInspector	1	1.000	-	-		oto139974
orthoMCL	1	0.900	-	-		OOG6_104800
Panther	1	1.100	-	-	LDO	PTHR10241
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X453
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	17.270