Protein Alignment LLGL2 and l(2)gl

DIOPT Version :9

• Sequence 1: XP_011523104.1
• Gene: LLGL2 / 3993
• HGNCID: 6629
• Length: 1024
• Species: Homo sapiens
• Sequence 2: NP_001245801.1
• Gene: l(2)gl / 33156
• FlyBaseID: FBgn0002121
• Length: 1161
• Species: Drosophila melanogaster
• Alignment Length: 1135
• Identity: 384/1135 - (33%)
• Similarity: 583/1135 - (51%)
• Gaps: 242/1135 - (21%)

Human     1 MRRFLR-PGHDPV--RERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAP 62
            |.:|:| .|..|.  |.||::|||.:.||.:|||||:||||.|.|.|:::||||::||:|::|.|
  Fly     1 MLKFIRGKGQQPSADRHRLQKDLFAYRKTAQHGFPHKPSALAYDPVLKLMAIGTQTGALKVFGQP 65

Human    63 GVEFMGLHQ-ENNAVTQIHL-----LPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRG 121
            |||..|.|. .||:.:::::     :.|..::::|...|.|.||.
  Fly    66 GVELYGQHTLLNNSASELNVQLLEWVYGTGRILSLTAANQLILWE-------------------- 110

Human   122 PPGAA--PSAT--------QITVVLPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQ 176
            |.||.  |..|        :::.:....|.:||::|||.||::.:.|..| .:::..|..|.||:
  Fly   111 PVGATLLPIKTLPFDGKLKKVSSLCCSLSKDLLWIGTEGGNIYQLDLHTF-TIKEPVIYHDVVLE 174

Human   177 RLPEEARHRRVFEM----VEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENI- 236
            ::|.      .:::    :|::::.|..|:::|:.|:|||.|:||.:.:.|...:::....:::
  Fly   175 QVPP------AYKLNPGAIESIRQLPNSPSKLLVAYNRGLCVLWDFESASVQRAYIAPGHGQSVG 233

Human   237 -----------WWQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLRSL--VPYGPFPCKAITRILW 288
                       |:          |:||||..|.:.:    |||..::  |||||.|||:|.| |:
  Fly   234 LTVNFEGSEFTWY----------HADGSYATWSIDN----PEPPSNVNYVPYGPDPCKSINR-LY 283

Human   289 LTTRQGLPFTIFQGGMPRASYGDRHCISV-IHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYA 352
            ...|:.....:|.|||||::|||.:|:|| ..||.:...||||:||.|.|..|.:.    |....
  Fly   284 KGKRRSNDVIVFSGGMPRSAYGDHNCVSVHASDGHKVCLDFTSKVIDFFVTFENNR----DVAEV 344

Human   353 LVVLAEEELVVIDLQTAGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNAHFST 417
            ||||.||||...||.......::.|||.|:|.||:||::..|.:...::|.|:.||..|:..:|.
  Fly   345 LVVLLEEELCAYDLTDPNICAIKAPYLHSVHASAVTCNYLASEVVQSVYESILRAGDEQDIDYSN 409

Human   418 MEWPIDGGTSLTP----------APPQRDLLLTGHEDGTVRFWDASGVCLRLLYKLSTVRVFLTD 472
            :.|||.|||  .|          |....::||||||||:|:|||.:||.|:.:|...|..:|.::
  Fly   410 ISWPITGGT--LPDNLEESVEEDATKLYEILLTGHEDGSVKFWDCTGVLLKPIYNFKTSSIFGSE 472

Human   473 TDPNE----NFSAQGEDEW-PPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLAVAGTAGQVLVLE 532
            :|..:    :.||:..||. ||.||.|.||||||||||.::||..|..:|.|.|.|||||:::.:
  Fly   473 SDFRDDAAADMSAEQVDEGEPPFRKSGLFDPYSDDPRLAVKKIAFCPKTGQLIVGGTAGQIVIAD 537

Human   533 LNDEAAEQAVEQVEADLLQDQEGYRWKGHERLAARSG-------PVRFEPGFQPFVLVQCQPPAV 590
            ..|...:.:::.:..:|:.|::|:.||||::|..||.       |.. |.|.....::|..|||.
  Fly   538 FIDLPEKVSLKYISMNLVSDRDGFVWKGHDQLNVRSNLLDGEAIPTT-ERGVNISGVLQVLPPAS 601

Human   591 VTSLALHSEWRLVAFGTSHGFGLFDHQQRRQVFVKCTLHPSDQLALEGPLSRVKSLKKSLRQSFR 655
            :|.:||.:.|.||:.||:||..|||.:....||.:|||:|:|.......|||.||.|||||:|||
  Fly   602 ITCMALEASWGLVSGGTAHGLVLFDFKNFVPVFHRCTLNPNDLTGAGEQLSRRKSFKKSLRESFR 666

Human   656 RMRRSRVSSRKRHPAGPPGEVRPEAQEGSAKAERPGLQNMELAPVQRKIEARSAEDSFTGFVRTL 720
            ::|:.| |:|.......|                   ..:|..||:|:||||.|:|.....||.|
  Fly   667 KLRKGR-STRTNQSNQVP-------------------TTLEARPVERQIEARCADDGLGSMVRCL 711

Human   721 YFADTYLKDSSRHCPSLWAGTNGGTIYAFSLRVPPAER--------------RMDEPVRAEQAKE 771
            .||.||:.:.:...|:||:.||..|:..|.|.:|||:.              .|...:.|:.|||
  Fly   712 LFAKTYVTNVNITSPTLWSATNASTVSVFLLHLPPAQTAATAVPSASGNAPPHMPRRISAQLAKE 776

Human   772 IQLMHRAPVVGILVLDGHSVPLPEPLEVAHDLSKSPDMQGSHQLLVVSEEQFKVFTLPKVSAKLK 836
            |||.||||||||.:.|....|:.:       |:...:....|::|:.||||||||:||::....|
  Fly   777 IQLKHRAPVVGISIFDQAGSPVDQ-------LNAGENGSPPHRVLIASEEQFKVFSLPQLKPINK 834

Human   837 LKLTALEGSRVRRVSVAHFGS----------------------------------------RRAE 861
            .||||.||:|:||:   ||||                                        .|.:
  Fly   835 YKLTANEGARIRRI---HFGSFSCRISPETLQSMHGCSPTKSTRSHGDGEADPNISGSLAVSRGD 896

Human   862 DYGEHHLAVLTNLGDIQVVSLPLLKPQVRYSCIRREDVSGIASCVFTKYGQGFYLISPSEFERFS 926
            .|.|..|..|||:|||.|:|:|.||.|:..:.:||||::|::|..||..|:..|::|.||.:|.:
  Fly   897 VYNETALICLTNMGDIMVLSVPELKRQLNAAAVRREDINGVSSLCFTNSGEALYMMSSSELQRIA 961

Human   927 LSTKWLVEP----------------------------RC--LVDSAETKN-------HRPG---- 950
            |:|..:|:|                            .|  :|::.|.||       .||.
  Fly   962 LATSRVVQPTGVVPVEPLENEESVLEENDAENNKETYACDEVVNTYEIKNPSGISICTRPAEENV 1026

Human   951 --------NGAGPKKAPSRARNSGTQSDGE 972
                    ||.....:|::|..:.:.|.|:
  Fly  1027 GRNSVQQVNGVNISNSPNQANETISSSIGD 1056

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LLGL2	XP_011523104.1	WD40 repeat	36..72	CDD:293791	20/36 (56%)
		WD40	<40..262	CDD:225201	64/253 (25%)
		WD40 repeat	77..111	CDD:293791	6/38 (16%)
		WD40 repeat	116..157	CDD:293791	13/50 (26%)
		WD40 repeat	191..228	CDD:293791	12/36 (33%)
		WD40 repeat	236..273	CDD:293791	10/50 (20%)
		LLGL	271..371	CDD:369834	46/102 (45%)
l(2)gl	NP_001245801.1	WD40 repeat	39..78	CDD:293791	20/38 (53%)
		WD40 repeat	84..126	CDD:293791	11/61 (18%)
		WD40 repeat	131..174	CDD:293791	13/43 (30%)
		WD40 repeat	188..224	CDD:293791	12/35 (34%)
		LLGL	268..>338	CDD:285555	35/70 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158369
Domainoid	1	1.000	310	1.000	Domainoid score	I1326
eggNOG	1	0.900	-	-		E1_KOG1983
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	654	1.000	Inparanoid score	I783
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48039
OrthoDB	1	1.010	-	-		D113391at33208
OrthoFinder	1	1.000	-	-		FOG0000702
OrthoInspector	1	1.000	-	-		otm40558
orthoMCL	1	0.900	-	-		OOG6_104800
Panther	1	1.100	-	-	LDO	PTHR10241
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X453
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770