DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LLGL2 and SPAC1F3.03

DIOPT Version :9

Sequence 1:	XP_011523104.1	Gene:	LLGL2 / 3993	HGNCID:	6629	Length:	1024	Species:	Homo sapiens
Sequence 2:	NP_593006.1	Gene:	SPAC1F3.03 / 2542372	PomBaseID:	SPAC1F3.03	Length:	1004	Species:	Schizosaccharomyces pombe

Alignment Length:	601	Identity:	125/601 - (20%)
Similarity:	213/601 - (35%)	Gaps:	173/601 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    19 DLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQENNAVTQIHLLP 83
            ||.:|      ||...|..........:|||.:.:..|.:||...|:.:.:   .:..|.:|:..
pombe    34 DLNRF------GFSLNPVLWCLDHQQGLLAIVSSTNRIYIYGKQHVQSVIV---PDCSTIVHIAL 89

Human    84 GQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSAT-----QITVVLPHSSCEL 143
            ....|:.:...|::..:.|......|:                |:||     ::|..:...:.:.
pombe    90 CAAYLIVIDSRNTVLSYPLMKHRDLSK----------------PAATYFLKQKVTCTVTDPTIDW 138

Human   144 LYLGTESGNVF-------------VVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEMVEALQ 195
            ::.|...|:|.             |..|...|..|.|.:.    ....|...:    ...|.::|
pombe   139 VFFGMSDGSVVPWDVTRHCLGKFKVPNLYVPRHEEWRMMG----YSYAPVPGK----LSPVVSVQ 195

Human   196 EHPRDPNQILIGYSRGLVVIWDLQGSRVLYHF------------LSSQQ-----LENIWWQRDGR 243
            .||:|...|||.|..| ||::.::...|:..:            ||...     ::.|.|...|.
pombe   196 IHPKDLGVILIAYPDG-VVLYSIRTDEVIRFYELEYAPGSTAAVLSPHNYRRPIVKGIEWSPWGD 259

Human   244 LLVSCHSDGSYCQWPVSSEAQQPEPLRSLV-----PYGPF---PCKA----ITRILWLTTRQ-GL 295
            ..||.::|.::..|.|..|  .|..:|:.|     .|.|.   |.|.    |..:.|..... .:
pombe   260 HFVSYYTDSTFAFWDVDQE--YPVQVRNFVDSNIHTYTPMQRNPPKTELEPIRSMRWCCCEDPTV 322

Human   296 PFTIFQGGMPRA---------SYGDRHCISVI--------HDGQQTAFDFTS--RVIGFTVLTEA 341
            .|.:..||:|:.         ||.:......:        :...|..|.|..  .|....|:..:
pombe   323 SFILMLGGLPKEAPVKGISLFSYRNLPAKKDVETFAEFFANPNSQRFFPFIDIPPVRDMLVIPSS 387

Human   342 DPAAT-FDDPYALVVLAEE-ELVVIDLQTAGWP------PVQLPYLAS-LHCSAITCSHHVSNIP 397
            .|... ..:|..|::|:|: .|.::|:.|....      |..|.:||| ....|.      ..:.
pombe   388 SPHYNGSHNPKNLLLLSEDNSLSLLDISTGNISNMSLSIPPSLCFLASDFRVIAF------QTVT 446

Human   398 LKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAP------PQRDLLLTGHEDG-TVRFWDAS-- 453
            .|:|.:|....| .|:|:|.    :.||   :|:|      .:|:||:|  ..| ::..||.|
pombe   447 KKVWNQIEDTIS-VNSHYSC----LFGG---SPSPGYLKKLDERNLLIT--STGLSLSIWDISQG 501

Human   454 ----GVCLRLLYKLSTVRVFLTDTDPNENFSAQGEDEWPPLRKVGSFDPYSDDPRLGIQKIFLCK 514
                .:|:.|.:. |.:|..||   |:...:            ..||..|:.:        |.|
pombe   502 FMNPSLCVNLDFS-SVMRKHLT---PSAFIT------------TASFSTYNPE--------FSC- 541

Human   515 YSGYLAVAGTAGQVLV 530
                   |.:.|:|:|
pombe   542 -------ADSFGRVIV 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LLGL2	XP_011523104.1	WD40 repeat	36..72	CDD:293791	7/35 (20%)
		WD40	<40..262	CDD:225201	49/256 (19%)
		WD40 repeat	77..111	CDD:293791	6/33 (18%)
		WD40 repeat	116..157	CDD:293791	8/58 (14%)
		WD40 repeat	191..228	CDD:293791	13/48 (27%)
		WD40 repeat	236..273	CDD:293791	11/36 (31%)
		LLGL	271..371	CDD:369834	26/133 (20%)
SPAC1F3.03	NP_593006.1	WD40	45..283	CDD:295369	51/267 (19%)
		WD40 repeat	45..79	CDD:293791	7/36 (19%)
		WD40 repeat	85..122	CDD:293791	8/52 (15%)
		WD40 repeat	127..185	CDD:293791	10/61 (16%)
		WD40 repeat	192..229	CDD:293791	12/37 (32%)
		WD40 repeat	249..297	CDD:293791	13/49 (27%)
		WD40 repeat	309..359	CDD:293791	8/49 (16%)
		Lgl_C	524..899	CDD:285762	9/55 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1983
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10241
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.000