DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LLGL2 and Llgl2

DIOPT Version :9

Sequence 1:	XP_011523104.1	Gene:	LLGL2 / 3993	HGNCID:	6629	Length:	1024	Species:	Homo sapiens
Sequence 2:	NP_001239461.1	Gene:	Llgl2 / 217325	MGIID:	1918843	Length:	1051	Species:	Mus musculus

Alignment Length:	1051	Identity:	932/1051 - (88%)
Similarity:	959/1051 - (91%)	Gaps:	27/1051 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MRRFLRPGHDPVRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVE 65
            ||||||.||||.|||||||||||||||||||||||||||||||||||||||||||:|||||||||
Mouse     1 MRRFLRTGHDPARERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAVKLYGAPGVE 65

Human    66 FMGLHQENNAVTQIHLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSAT 130
            |||||:|||||.|||.||||||||||||||||||||||||||.|||||:||||||||||||||||
Mouse    66 FMGLHKENNAVLQIHFLPGQCQLVTLLDDNSLHLWSLKVKGGVSELQEEESFTLRGPPGAAPSAT 130

Human   131 QITVVLPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEMVEALQ 195
            |:|.:|||||.||||||||||||||||||.||.|.||||.||.|||.||||||||||||||||||
Mouse   131 QVTEILPHSSGELLYLGTESGNVFVVQLPGFRTLHDRTICSDEVLQWLPEEARHRRVFEMVEALQ 195

Human   196 EHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIWWQRDGRLLVSCHSDGSYCQWPVS 260
            |||||||||||||||||||||||||||.|.||||||||||..|||||.|:|:||||||:||||||
Mouse   196 EHPRDPNQILIGYSRGLVVIWDLQGSRALSHFLSSQQLENASWQRDGCLIVTCHSDGSHCQWPVS 260

Human   261 SEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGDRHCISVIHDGQQTA 325
            |:.|.||||||.:|||||||||||:|.||||||||||||||||||||||||||||||:|:|||||
Mouse   261 SDTQNPEPLRSSIPYGPFPCKAITKIFWLTTRQGLPFTIFQGGMPRASYGDRHCISVVHNGQQTA 325

Human   326 FDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEELVVIDLQTAGWPPVQLPYLASLHCSAITCS 390
            ||||||||.||||:||||||.||||||||||||||||||||||.|||||||||||||||||||||
Mouse   326 FDFTSRVIDFTVLSEADPAAAFDDPYALVVLAEEELVVIDLQTPGWPPVQLPYLASLHCSAITCS 390

Human   391 HHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDLLLTGHEDGTVRFWDASGV 455
            ||||||||||||||||||||||:|||||||||||||||.|.||||||||||||||||||||||||
Mouse   391 HHVSNIPLKLWERIIAAGSRQNSHFSTMEWPIDGGTSLAPPPPQRDLLLTGHEDGTVRFWDASGV 455

Human   456 CLRLLYKLSTVRVFLTDTDPNENFSAQGEDEWPPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLA 520
            ||||||||||||||||||||:||..||||||||||||||||||||||||||||||||||||||||
Mouse   456 CLRLLYKLSTVRVFLTDTDPSENLIAQGEDEWPPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLA 520

Human   521 VAGTAGQVLVLELNDEAAEQAVEQVEADLLQDQEGYRWKGHERLAARSGPVRFEPGFQPFVLVQC 585
            |||||||||||||||||||.|||||||||||||||||||||||||||.|||.||.||||||||||
Mouse   521 VAGTAGQVLVLELNDEAAEHAVEQVEADLLQDQEGYRWKGHERLAARPGPVCFEAGFQPFVLVQC 585

Human   586 QPPAVVTSLALHSEWRLVAFGTSHGFGLFDHQQRRQVFVKCTLHPSDQLALEGPLSRVKSLKKSL 650
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   586 QPPAVVTSLALHSEWRLVAFGTSHGFGLFDHQQRRQVFVKCTLHPSDQLALEGPLSRVKSLKKSL 650

Human   651 RQSFRRMRRSRVSSRKRHPAGPPGEVRPEAQEG----------------------SAKAERPGLQ 693
            ||||||||||||||.||.|.||.|||||:||..                      :.||||.|||
Mouse   651 RQSFRRMRRSRVSSHKRRPGGPTGEVRPQAQSSHLQDHTALPQDLNPDQAQAQAVNIKAERTGLQ 715

Human   694 NMELAPVQRKIEARSAEDSFTGFVRTLYFADTYLKDSSRHCPSLWAGTNGGTIYAFSLRVPPAER 758
            ||||||||||||||||||||||||||||||||||:|||||||||||||||||:||||||||||||
Mouse   716 NMELAPVQRKIEARSAEDSFTGFVRTLYFADTYLRDSSRHCPSLWAGTNGGTVYAFSLRVPPAER 780

Human   759 RMDEPVRAEQAKEIQLMHRAPVVGILVLDGHSVPLPEPLEVAHDLSKSPDMQGSHQLLVVSEEQF 823
            |.|||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||
Mouse   781 RTDEPVRAEQAKEIQLMHRAPVVGILVLDGHNVPLPEPLEVAHDLSKSPDMQGSHQLLVVSEEQF 845

Human   824 KVFTLPKVSAKLKLKLTALEGSRVRRVSVAHFGSRRAEDYGEHHLAVLTNLGDIQVVSLPLLKPQ 888
            |||||||||||||||||||||||||||.||||||.|||||||||||||||||||||||:||||||
Mouse   846 KVFTLPKVSAKLKLKLTALEGSRVRRVGVAHFGSCRAEDYGEHHLAVLTNLGDIQVVSMPLLKPQ 910

Human   889 VRYSCIRREDVSGIASCVFTKYGQGFYLISPSEFERFSLSTKWLVEPRCLVDSAETKNH-RP--G 950
            |||||||||||||||||||||||||||||||||||||||||||||||||||||.:.|.| ||  |
Mouse   911 VRYSCIRREDVSGIASCVFTKYGQGFYLISPSEFERFSLSTKWLVEPRCLVDSTKAKKHNRPSNG 975

Human   951 NGAGPKKAPS-RARNSGTQSDGEEKQPGLVMERALLSDERVLKEIQSTLEGDRGS-GNWRSHRAA 1013
            ||.|.|...| ..|||.:||||:||:||.|||.|||:|..|||||||||||||.| |||..||.|
Mouse   976 NGTGLKMTSSGHVRNSKSQSDGDEKKPGPVMEHALLNDAWVLKEIQSTLEGDRRSYGNWHPHRVA 1040

Human  1014 VGCSLSNGGAE 1024
            |||.||||.||
Mouse  1041 VGCRLSNGEAE 1051

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LLGL2	XP_011523104.1	WD40 repeat	36..72	CDD:293791	34/35 (97%)
		WD40	<40..262	CDD:225201	197/221 (89%)
		WD40 repeat	77..111	CDD:293791	30/33 (91%)
		WD40 repeat	116..157	CDD:293791	36/40 (90%)
		WD40 repeat	191..228	CDD:293791	34/36 (94%)
		WD40 repeat	236..273	CDD:293791	27/36 (75%)
		LLGL	271..371	CDD:369834	89/99 (90%)
Llgl2	NP_001239461.1	WD40 repeat	35..67	CDD:293791	30/31 (97%)
		WD40	<36..267	CDD:225201	203/230 (88%)
		WD40 repeat	76..120	CDD:293791	39/43 (91%)
		WD40 repeat	127..153	CDD:293791	21/25 (84%)
		WD40 repeat	192..228	CDD:293791	33/35 (94%)
		LLGL	271..371	CDD:369834	89/99 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83968412
Domainoid	1	1.000	1014	1.000	Domainoid score	I1627
eggNOG	1	0.900	-	-		E1_KOG1983
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3323
Inparanoid	1	1.050	1861	1.000	Inparanoid score	I1888
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48039
OrthoDB	1	1.010	-	-		D113391at33208
OrthoFinder	1	1.000	-	-		FOG0000702
OrthoInspector	1	1.000	-	-		oto123815
orthoMCL	1	0.900	-	-		OOG6_104800
Panther	1	1.100	-	-	LDO	PTHR10241
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6137
SonicParanoid	1	1.000	-	-		X453
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	18	18.300