DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LLGL2 and lgl-1

DIOPT Version :9

Sequence 1:	XP_011523104.1	Gene:	LLGL2 / 3993	HGNCID:	6629	Length:	1024	Species:	Homo sapiens
Sequence 2:	NP_508169.2	Gene:	lgl-1 / 180435	WormBaseID:	WBGene00018987	Length:	941	Species:	Caenorhabditis elegans

Alignment Length:	1001	Identity:	216/1001 - (21%)
Similarity:	401/1001 - (40%)	Gaps:	152/1001 - (15%)

- Green bases have known domain annotations that are detailed below.

Human     3 RFLRPG--HDPVRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVE 65
            ||:|..  |:| .|........|::....||.....|..|...  .:.||:::|.:..||..|..
Worm     6 RFIRSKFYHEP-EEHAIEQYAVFDEGNRGGFTSDVVAFDYHNG--CVVIGSKNGEVTFYGYRGAS 67

Human    66 F---MGLHQENNA-VTQIHLLPGQCQLVTLLDDNSLHLWSLKVKGGA----SELQEDESFTLRGP 122
            :   :....||.| :..|..:.....||  |.|..| :..:.:|.|.    .||:.:|:...:..
Worm    68 WTVSLSKDSENKARIEHIFFISSNIALV--LCDGQL-IIPIHIKDGVITKKEELRFNENHKSKWD 129

Human   123 PGAAPSATQITVVLPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQR------LPEE 181
            .......:..|..|..|....:|                 .::.:|:.|:.:::.      ||::
Worm   130 ITHVQKLSDDTFALVFSMNNTIY-----------------RIKSKTLKSEVLVKAEDFEKWLPDD 177

Human   182 ARHRRVFEMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFL---SSQQLENIWWQRDGR 243
            ..       :.::...|..|:.:::....|.|.::: :...|:...|   ..:.::.:.|..:.:
Worm   178 TE-------LASITCLPEKPSILMLIAENGCVGVFN-ESQFVMKTSLRNYEDEAIQKLHWSSEKK 234

Human   244 ----LLVSCHSDGSYCQW--PVSSEAQ---QPEPLRSLVPYGPFPCKAITRILWLTTRQGLP--- 296
                ..:||::  .|.:|  .|..:.|   |...:.|...:||:||..| |...:......|
Worm   235 KNVAFGISCNN--KYTKWEFTVGKDCQISAQEVNVYSANQFGPYPCHQI-RHFSVCADASDPNEN 296

Human   297 FTIFQGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAATFDD---PYALVVLAE 358
            |.|:|||.....|.||..|::.|.......:.:|.::|...:     :.:::|   ...:::..:
Worm   297 FLIYQGGKSSGKYDDRDLITISHGDFVEKLELSSEIVGIVGV-----SGSYEDCKKSGVVLICTK 356

Human   359 EELVVIDLQTAGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSR--QNAHFSTMEWP 421
            .|::.|||:......:|..:..|::.|..|.......|...:|.|:.:|...  :....||.:||
Worm   357 CEIIGIDLERESLNMMQPKHFLSINNSTPTTHSRAIEIEENVWNRLESASKSYWETNQMSTRDWP 421

Human   422 IDGGTSL-TPAPPQ----RDLLLTGHEDGTVRFWDASGVCLRLLYKLSTVRVF--LTDTDPNENF 479
            ::....: |.|..|    |.:.|:||.:|.:..|.:.||.:.|:..:.|...|  .:..| ||:.
Worm   422 LNFQKKIVTDANHQRASYRQVYLSGHSNGNICIWSSGGVGMSLMLVIRTSLEFDGASSFD-NEDS 485

Human   480 SAQGEDEWP--PLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLAVAGTAGQVLVLELNDEAAEQAV 542
            :....||.|  |:||:|.:||:.||..:.|.::.....||.:......|.||:.||.|.|  :.:
Worm   486 NYYNSDEKPEKPVRKIGLYDPFDDDEEMCITRVHFDPKSGIVIGTNRGGYVLMYELWDSA--RTL 548

Human   543 EQVEADLLQDQEGYRWKGHERLAARSGPVRFEPGFQ---------PFVLVQCQPPAVVTSLALHS 598
            ...||..:.............|..|...:::..|:|         |.|. ...|...:|.:....
Worm   549 THWEATPISCNNSPPDTRKRALKPRKAELKYNAGYQIRLKNESDLPLVF-SMHPSHRITDIVYLH 612

Human   599 EWRLVAFGTSHGFGLFDHQQRRQVFVKCTLHPSDQLA--LEGPLSRVKSLKKSLRQSFRRMRR-- 659
            ::..:|.|::.|..:.|......|:.......::..:  ......|.||||||||::|||.::
Worm   613 KYHCLAVGSNFGIVMLDVNFGYLVYANSFNDDNNDSSNVSANQFQRFKSLKKSLRKTFRRKKKGT 677

Human   660 -------SRVSSRKRHPAGPPGEVR-PEAQEGSAKAERPGLQNMELAPVQRKIEARS-------- 708
                   ..|:|...|........| .:.:|.....|||             ||||.
Worm   678 ETLMDSGGAVASSSNHVQHETSPKRIDDFEEEEVFMERP-------------IEAREELGVLDCY 729

Human   709 AEDSFTGFVRTLYFADTYLKDSSRHCPSLWAGTNGGTIYAFSLRVPPAERRMDEPVRAEQAKEIQ 773
            ||:| .|.|..|......:.|.......:..|.:.|::|.:::.......||  ..:|||.|::.
Worm   730 AENS-KGTVTCLRMMRFPVLDDKNVDDIIAVGLHEGSVYFYAISEHDVGLRM--TFKAEQIKKLS 791

Human   774 LMHRAPVVGILVLDGHSVPLPEPLEVAHDLSKSPD-MQGSHQLLVVSEEQFKVFTLPKVSAKLKL 837
            :.|:.|||.:                  |::.... ...|.:::|::|||.:::....:..:...
Worm   792 IPHKQPVVNL------------------DITNEEGYFSASTRIVVITEEQLRIYNCQPMVKRDSY 838

Human   838 KLTALEGSRVRRVSVAHFGSRRAEDYGEHHLAVLTNLGDIQVVSLPLLKPQVRYSCIRREDVSGI 902
            |:|||||.:::...||...:::..:..|..:.::.|.|.::|.|:...........|...||..:
Worm   839 KITALEGLKIKNGMVARILNKKNSNNFESFVVLVANDGSLRVHSVQKASSFESRKFIDPIDVMAL 903

Human   903 ASCVFTKYGQGFYLISPSEFERFSLS 928
            .|...::.|...:||..||.:|.:::
Worm   904 NSSCLSRDGDVAFLIKSSELQRSTVN 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LLGL2	XP_011523104.1	WD40 repeat	36..72	CDD:293791	8/38 (21%)
		WD40	<40..262	CDD:225201	41/244 (17%)
		WD40 repeat	77..111	CDD:293791	8/37 (22%)
		WD40 repeat	116..157	CDD:293791	4/40 (10%)
		WD40 repeat	191..228	CDD:293791	5/36 (14%)
		WD40 repeat	236..273	CDD:293791	9/45 (20%)
		LLGL	271..371	CDD:369834	25/105 (24%)
lgl-1	NP_508169.2	LLGL	273..364	CDD:369834	22/96 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161470424
Domainoid	1	1.000	99	1.000	Domainoid score	I4899
eggNOG	1	0.900	-	-		E1_KOG1983
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48039
OrthoDB	1	1.010	-	-		D113391at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10241
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.820