Protein Alignment Afg3l2 and YME1

DIOPT Version :10

• Sequence 1: NP_730248.2
• Gene: Afg3l2 / 39922
• FlyBaseID: FBgn0036702
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: NP_015349.1
• Gene: YME1 / 856135
• SGDID: S000006228
• Length: 747
• Species: Saccharomyces cerevisiae
• Alignment Length: 791
• Identity: 252/791 - (31%)
• Similarity: 405/791 - (51%)
• Gaps: 112/791 - (14%)

  Fly    41 VYILPTELSPLLRYVVKQI-----QLLCKKP----PKGFEKYFEAGGKSSGQPKGSVGDKKPPAG 96
            :.:.||..:.:||....::     .||.:|.    .|.|.:::..  |:||:    :..||....
Yeast     6 ILVSPTVTTNVLRIFAPRLPQIGASLLVQKKWALRSKKFYRFYSE--KNSGE----MPPKKEADS 64

  Fly    97 SSKSASEKPSTSTPASVKPSRSQTDAKSDWNFGMFSNSSRGPAGKGGNSLGGRPLGENGGGGDRE 161
            |.|::::...:|...|..|..|.|:.|:.......|::......:..|.....|        |.:
Yeast    65 SGKASNKSTISSIDNSQPPPPSNTNDKTKQANVAVSHAMLATREQEANKDLTSP--------DAQ 121

  Fly   162 RWILLGAIGAVVLVGSFAFFEMGYKEISWKEFVNSYLSKGV----------VEKLEVVNKKWVRV 216
            .                ||:::..:....:..|:.:.:.|:          :|.|:.:.:.....
Yeast   122 A----------------AFYKLLLQSNYPQYVVSRFETPGIASSPECMELYMEALQRIGRHSEAD 170

  Fly   217 RLQQNSNSGSGVLWFNIGSVDSFERNLEAAQTEQGTESINFVPVIY------RNE-----VEAAS 270
            .::||..:.|     :.|:|:.   :|.::.:.|.....|| |.:|      |.|     |..::
Yeast   171 AVRQNLLTAS-----SAGAVNP---SLASSSSNQSGYHGNF-PSMYSPLYGSRKEPLHVVVSEST 226

  Fly   271 LTGL---LPTLLIIGFLVYMMRKSADMMGGGRGRKGGGLFGGVMQSTAKLTNPN---------EI 323
            .|.:   :..||:.|.|.|...:.               |..:.::|..|.:..         :.
Yeast   227 FTVVSRWVKWLLVFGILTYSFSEG---------------FKYITENTTLLKSSEVADKSVDVAKT 276

  Fly   324 GVGFKDVAGCEEAKIEIMEFVNFLKNPQQYIDLGAKIPKGAMLTGPPGTGKTLLAKATAGEANVP 388
            .|.|.||.||:||:.|:.|.|:|||:|.:|..||.|:|||.:|||||||||||||:||||||.|.
Yeast   277 NVKFDDVCGCDEARAELEEIVDFLKDPTKYESLGGKLPKGVLLTGPPGTGKTLLARATAGEAGVD 341

  Fly   389 FITVSGSEFLEMFVGVGPSRVRDMFAMARKHAPCILFIDEIDAVGRKRGGKTFGGHSEQENTLNQ 453
            |..:|||||.|::||||..|:||:||.||..||.|:||||:||:|.||..|   ..:..:.||||
Yeast   342 FFFMSGSEFDEVYVGVGAKRIRDLFAQARSRAPAIIFIDELDAIGGKRNPK---DQAYAKQTLNQ 403

  Fly   454 LLVEMDGFNTTTNVVVLAATNRVDILDKALMRPGRFDRQIYVPAPDIKGRASIFKVHLGNLKTSL 518
            ||||:|||:.|:.::::.|||..:.|||||.||||||:.:.|..||::|||.|.|.|:  .|.:|
Yeast   404 LLVELDGFSQTSGIIIIGATNFPEALDKALTRPGRFDKVVNVDLPDVRGRADILKHHM--KKITL 466

  Fly   519 DKNELSRKMAALTPGFTGADIANVCNEAALIAARDSKDSIVLKHFEQAIERVIAGMEKKTNVLAP 583
            ..|.....:|..|||.:||::||:.|:||:.|.:.:..|:.:.|||.|.::::.|.|:||.||..
Yeast   467 ADNVDPTIIARGTPGLSGAELANLVNQAAVYACQKNAVSVDMSHFEWAKDKILMGAERKTMVLTD 531

  Fly   584 EEKRTVAHHEAGHAVAGWFLEHADPLLKVSIIPRGKGLGYAQYLPK-DHYLLSKEQLFDRMCMTL 647
            ..::..|.||||||:...:...|.||.|.:|:|||:.||....||: |...::|.:...|:.:.:
Yeast   532 AARKATAFHEAGHAIMAKYTNGATPLYKATILPRGRALGITFQLPEMDKVDITKRECQARLDVCM 596

  Fly   648 GGRVAEELFFNR--ITTGAQDDLKKITDIAYSQVVRFGMNEKVGQVSFDVGQAGDPVFSKPYSED 710
            ||::||||.:.:  .|:|...||:..|..|.:.|.::||::.||.|:.....       :.:|..
Yeast   597 GGKIAEELIYGKDNTTSGCGSDLQSATGTARAMVTQYGMSDDVGPVNLSENW-------ESWSNK 654

  Fly   711 TAQLIDNEVRSIIKCAHEATTSLLTKHKENVQKVAERLLQNEVLSRDDMIELL-GPRPFKEKSTY 774
            ...:.||||..::|.:.|....||||....:.::|:.|::.|.|...::.::. |.:..|.|::.
Yeast   655 IRDIADNEVIELLKDSEERARRLLTKKNVELHRLAQGLIEYETLDAHEIEQVCKGEKLDKLKTST 719

  Fly   775 EEFVEGTGSFE 785
            ...|||..|.|
Yeast   720 NTVVEGPDSDE 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Afg3l2	NP_730248.2	HflB	168..765	CDD:440233	218/633 (34%)
YME1	NP_015349.1	HflB	<269..709	CDD:440233	189/451 (42%)