Protein Alignment Afg3l2 and YTA12

DIOPT Version :10

• Sequence 1: NP_730248.2
• Gene: Afg3l2 / 39922
• FlyBaseID: FBgn0036702
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: NP_013807.1
• Gene: YTA12 / 855114
• SGDID: S000004695
• Length: 825
• Species: Saccharomyces cerevisiae
• Alignment Length: 724
• Identity: 356/724 - (49%)
• Similarity: 482/724 - (66%)
• Gaps: 48/724 - (6%)

  Fly   103 EKPSTSTPASVKPSRSQTDAKSDWNFGMF-SNSSRG-------PAGKGGNSLGGRPLGENGGGGD 159
            ||...:.|:..|.:|::..       |.| .|:||.       |..|...:....|:.:|
Yeast   125 EKEEENGPSKAKSNRTKEQ-------GYFEGNNSRNIPPPPPPPPPKPPLNDPSNPVSKN----- 177

  Fly   160 RERWILLGAIGAVVLVGSFAFFEMG----YKEISWKEFVNSYLSKGVVEKLEVVNKKWVRVRLQQ 220
                :.|..||....:.||....:.    ..||:|::|....|:||.|.||.||||..|:|.|..
Yeast   178 ----VNLFQIGLTFFLLSFLLDLLNSLEEQSEITWQDFREKLLAKGYVAKLIVVNKSMVKVMLND 238

  Fly   221 N-----SNSGSGVLWFNIGSVDSFERNLEAAQTEQGTESINFVPVIYRNEVE-AASLTGLLPTLL 279
            |     .|.|....:|.|||:||||..|:.||.|...:....:||:|..|.. |.::..:|||:|
Yeast   239 NGKNQADNYGRNFYYFTIGSIDSFEHKLQKAQDELDIDKDFRIPVLYVQEGNWAKAMFQILPTVL 303

  Fly   280 IIGFLVYMMRKSADMMGGGRGRKGGGLFGGVMQSTAKLTNPNEIGVGFKDVAGCEEAKIEIMEFV 344
            :|..::::.|:||...||.|    ||:||.......|.....::.:.|||||||:|||.||||||
Yeast   304 MIAGIIWLTRRSAQAAGGSR----GGIFGLSRSKAKKFNTETDVKIKFKDVAGCDEAKEEIMEFV 364

  Fly   345 NFLKNPQQYIDLGAKIPKGAMLTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPSRV 409
            :|||.|.:|..:|||||:||:|:||||||||||||||||||.|||..||||||:|||||||.:||
Yeast   365 SFLKEPSRYEKMGAKIPRGAILSGPPGTGKTLLAKATAGEAGVPFYFVSGSEFVEMFVGVGAARV 429

  Fly   410 RDMFAMARKHAPCILFIDEIDAVGRKR-GGKTFGGHSEQENTLNQLLVEMDGFNTTTNVVVLAAT 473
            ||:|..||::||.|:|||||||:|:.| .|...|.:.|:||||||:|||||||....:|||||.|
Yeast   430 RDLFKTARENAPSIVFIDEIDAIGKARQKGNFSGANDERENTLNQMLVEMDGFTPADHVVVLAGT 494

  Fly   474 NRVDILDKALMRPGRFDRQIYVPAPDIKGRASIFKVHLGNLKTSLDKNELSRKMAALTPGFTGAD 538
            ||.|||||||:|||||||.|.:..|:::||.:||.|||.:||.:.:..:|..::|||||||:|||
Yeast   495 NRPDILDKALLRPGRFDRHINIDKPELEGRKAIFAVHLHHLKLAGEIFDLKNRLAALTPGFSGAD 559

  Fly   539 IANVCNEAALIAARDSKDSIVLKHFEQAIERVIAGMEKKTNVLAPEEKRTVAHHEAGHAVAGWFL 603
            ||||||||||||||..:|::.|.||||||||||.|:|:|:.:|:||||:.||:|||||||.||:|
Yeast   560 IANVCNEAALIAARSDEDAVKLNHFEQAIERVIGGVERKSKLLSPEEKKVVAYHEAGHAVCGWYL 624

  Fly   604 EHADPLLKVSIIPRGKG-LGYAQYLPKDHYLLSKEQLFDRMCMTLGGRVAEELFFNRITTGAQDD 667
            ::|||||||||||||:| ||||||||.|.:||:::||.|||.|:|||||:|||.|..:|:||.||
Yeast   625 KYADPLLKVSIIPRGQGALGYAQYLPGDIFLLTEQQLKDRMTMSLGGRVSEELHFPSVTSGASDD 689

  Fly   668 LKKITDIAYSQVVRFGMNEKVGQVSFDVGQAGDPVFSKPYSEDTAQLIDNEVRSIIKCAHEATTS 732
            .||:|.:|.:.|...||::|:|.|::.  :..|...:||:|::|..:||:||..|::..|:..|.
Yeast   690 FKKVTSMATAMVTELGMSDKIGWVNYQ--KRDDSDLTKPFSDETGDIIDSEVYRIVQECHDRCTK 752

  Fly   733 LLTKHKENVQKVAERLLQNEVLSRDDMIELLGPRPFKEKSTYEEFVEGTGSFEEDTTLPEGLKSW 797
            ||.:..|:|:|:|:.||:.|||:|:|||:|||.|||.|::  :.|.:....:|.:..    .|..
Yeast   753 LLKEKAEDVEKIAQVLLKKEVLTREDMIDLLGKRPFPERN--DAFDKYLNDYETEKI----RKEE 811

  Fly   798 NKEKERTEP 806
            .|.::|.||
Yeast   812 EKNEKRNEP 820

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Afg3l2	NP_730248.2	HflB	168..765	CDD:440233	329/608 (54%)
YTA12	NP_013807.1	FtsH_ext	<205..282	CDD:377663	32/76 (42%)
		FtsH_fam	290..784	CDD:273520	288/499 (58%)