DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6512 and BCS1

DIOPT Version :9

Sequence 1:	NP_730248.2	Gene:	CG6512 / 39922	FlyBaseID:	FBgn0036702	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_010663.1	Gene:	BCS1 / 851981	SGDID:	S000002783	Length:	456	Species:	Saccharomyces cerevisiae

Alignment Length:	493	Identity:	116/493 - (23%)
Similarity:	190/493 - (38%)	Gaps:	151/493 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 SEKP------STSTP---ASVKPSRSQTDAKSDWNFGMFSNSSRGPAGK-GGNSLGGRPLGENGG 156
            |:||      ..:||   ..:.|..::|.          ::|.|....| .|:::...|....||
Yeast     2 SDKPIDIQYDKQATPNLSGVITPPTNETG----------NDSVREKLSKLVGDAMSNNPYFAAGG 56

  Fly   157 GGDRERWILLGAIGAVVLVG-----------------------SFAFFEMGYKEISW----KEFV 194
            |     .::||...||...|                       |:|:|      ::|    .:.|
Yeast    57 G-----LMILGTGLAVARSGIIKASRVLYRQMIVDLEIQSKDKSYAWF------LTWMAKHPQRV 110

  Fly   195 NSYLSKGVVEKLEVVNKKWVRVRLQQNSNS----------GSGVLWFNIGSVDSF-----ERNLE 244
            :.:||              ||....|:.|.          |.|..|  |....:|     ||:.:
Yeast   111 SRHLS--------------VRTNYIQHDNGSVSTKFSLVPGPGNHW--IRYKGAFILIKRERSAK 159

  Fly   245 AAQTEQGT--ESINFVPVIYR---------NEVEAASL-TGLLPTLLIIGFLVYMMRKSADMMGG 297
            ......|:  |::. :..:||         ||.:..:| |....|::...|             |
Yeast   160 MIDIANGSPFETVT-LTTLYRDKHLFDDILNEAKDIALKTTEGKTVIYTSF-------------G 210

  Fly   298 GRGRKGGGLFGGVMQSTAKLTNPNEIGVGFKDVAGCEEAKIEIMEFVNFLKNPQQYIDLGAKIPK 362
            ...||.|       |..||...|:.|    .| :|.:|..::  :..:|:||.:.|.|.|....:
Yeast   211 PEWRKFG-------QPKAKRMLPSVI----LD-SGIKEGILD--DVYDFMKNGKWYSDRGIPYRR 261

  Fly   363 GAMLTGPPGTGKTLLAKATAGEA--NVPFITVSGSEFLEMFVGVGPSRVRDMFAMARKHAPCILF 425
            |.:|.||||:|||...:|.|||.  |:..:.:|.:...:       .|:..:  |.......||.
Yeast   262 GYLLYGPPGSGKTSFIQALAGELDYNICILNLSENNLTD-------DRLNHL--MNNMPERSILL 317

  Fly   426 IDEIDAVGRKRG--GKTFGGHSEQENTLNQLLVEMDGFNTTTNVVVLAATNRVDILDKALMRPGR 488
            :::|||...||.  |:. |.||..  |.:.||..:||..::...:....||..:.||.|:|||||
Yeast   318 LEDIDAAFNKRSQTGEQ-GFHSSV--TFSGLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPGR 379

  Fly   489 FDRQIYVPAPDIKGRASIFKVHLGNLKTSLDKNELSRK 526
            .|.:::|      |.|:.::|....:|....:.::.:|
Yeast   380 IDYKVFV------GNATPYQVEKMFMKFYPGETDICKK 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6512	NP_730248.2	FtsH_ext	163..259	CDD:284011	25/139 (18%)
		FtsH_fam	271..764	CDD:273520	72/261 (28%)
		AAA	365..496	CDD:278434	43/134 (32%)
		Peptidase_M41	580..762	CDD:279742
BCS1	NP_010663.1	HflB	<1..456	CDD:223541	116/493 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900