DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6512 and VAR1

DIOPT Version :9

Sequence 1:	NP_730248.2	Gene:	CG6512 / 39922	FlyBaseID:	FBgn0036702	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_568604.1	Gene:	VAR1 / 834232	AraportID:	AT5G42270	Length:	704	Species:	Arabidopsis thaliana

Alignment Length:	774	Identity:	288/774 - (37%)
Similarity:	406/774 - (52%)	Gaps:	147/774 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LPTELSPLLRYVVKQIQLLCKKPPKGFEKYFEAGGKSSGQPKGSVGDK--KPPAGSSKSASEKPS 106
            ||..:....||.:.|.:.|.|..|.  :....|...||..|:....::  :|||.:..:.::.|:
plant    34 LPFSVISRKRYQISQSEKLMKSLPS--QAALAALLFSSSSPQALAVNEPVQPPAPTITAEAQSPN 96

  Fly   107 TSTPASVKPSRSQTDAKSDWNFGMFSNSSRGPAGKGGNSL--GGRPLGENGGGGDRERWILLGAI 169
            .||                  ||.             |.|  ...|..::....|..:|
plant    97 LST------------------FGQ-------------NVLMTAPNPQAQSSDLPDGTQW------ 124

  Fly   170 GAVVLVGSFAFFEMGYKEISWKEFVNSYLSKGVVEKLEVVNKKWVRVRLQQNSNSGSGVLWFNIG 234
                               .:.||:|: :.||.||          ||:..::            |
plant   125 -------------------RYSEFLNA-VKKGKVE----------RVKFSKD------------G 147

  Fly   235 SVDSFERNLEAAQTEQGTESI----NFVPVIYRNEVEAASLTG------------LLPTLLIIGF 283
            ||    ..|.|....:.|..:    :.:.::..|.|:.:...|            ||..||..|.
plant   148 SV----LQLTAVDNRRATVIVPNDPDLIDILAMNGVDISVSEGEGGNGLFDFIGNLLFPLLAFGG 208

  Fly   284 LVYMMRKSADMMGGGRGRKGG-GLFGGVM---QSTAKLTNPNEIGVGFKDVAGCEEAKIEIMEFV 344
            |.|:.|       ||:|..|| |..||.|   :|.:|.....|.||.|.||||.::||:|:.|.|
plant   209 LFYLFR-------GGQGGAGGPGGLGGPMDFGRSKSKFQEVPETGVTFGDVAGADQAKLELQEVV 266

  Fly   345 NFLKNPQQYIDLGAKIPKGAMLTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPSRV 409
            :|||||.:|..||||||||.:|.|||||||||||:|.||||.|||.:.:.|||:|:|||||.|||
plant   267 DFLKNPDKYTALGAKIPKGCLLVGPPGTGKTLLARAVAGEAGVPFFSCAASEFVELFVGVGASRV 331

  Fly   410 RDMFAMARKHAPCILFIDEIDAVGRKRGGKTFGGHSEQENTLNQLLVEMDGFNTTTNVVVLAATN 474
            ||:|..|:..||||:||||||||||:||....||:.|:|.|:||||.|||||:..:.|:||||||
plant   332 RDLFEKAKSKAPCIVFIDEIDAVGRQRGAGMGGGNDEREQTINQLLTEMDGFSGNSGVIVLAATN 396

  Fly   475 RVDILDKALMRPGRFDRQIYVPAPDIKGRASIFKVHLGNLKTSLDKNELSRKMAALTPGFTGADI 539
            |.|:||.||:||||||||:.|..||:.||..|.|||  :...::.|:....|:|..||||||||:
plant   397 RPDVLDSALLRPGRFDRQVTVDRPDVAGRVQILKVH--SRGKAIGKDVDYEKVARRTPGFTGADL 459

  Fly   540 ANVCNEAALIAARDSKDSIVLKHFEQAIERVIAGMEKKTNVLAPEEKRTVAHHEAGHAVAGWFLE 604
            .|:.||||::|||.....|.......|:||:|||.|||..|::.|:||.||:||||||:.|..:.
plant   460 QNLMNEAAILAARRELKEISKDEISDALERIIAGPEKKNAVVSEEKKRLVAYHEAGHALVGALMP 524

  Fly   605 HADPLLKVSIIPRGKGLGYAQYLPKDHY----LLSKEQLFDRMCMTLGGRVAEELFF--NRITTG 663
            ..||:.|:||||||:..|...:.|.:..    |.|:..|.::|.:.||||||||:.|  ..:|||
plant   525 EYDPVAKISIIPRGQAGGLTFFAPSEERLESGLYSRSYLENQMAVALGGRVAEEVIFGDENVTTG 589

  Fly   664 AQDDLKKITDIAYSQVVRFGMNEKVGQVSFDVGQAGDPVF-------SKPYSEDTAQLIDNEVRS 721
            |.:|..:::.:|...|.|||.::|:|||:  ||.||...|       .|.||..||.::|.|||.
plant   590 ASNDFMQVSRVARQMVERFGFSKKIGQVA--VGGAGGNPFLGQSMSSQKDYSMATADVVDAEVRE 652

  Fly   722 IIKCAHEATTSLLTKHKENVQKVAERLLQNEVLSRDDMIELLGPRPFKEKSTYEEFVEG 780
            :::.|:.....::|...:.:.|:|:.|::.|.:..::.:.|              |::|
plant   653 LVEKAYVRAKEIITTQIDILHKLAQLLIEKETVDGEEFMSL--------------FIDG 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6512	NP_730248.2	FtsH_ext	163..259	CDD:284011	16/99 (16%)
		FtsH_fam	271..764	CDD:273520	244/521 (47%)
		AAA	365..496	CDD:278434	87/130 (67%)
		Peptidase_M41	580..762	CDD:279742	71/194 (37%)
VAR1	NP_568604.1	FtsH_fam	192..694	CDD:273520	243/526 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	196	1.000	Domainoid score	I899
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D217929at2759
OrthoFinder	1	1.000	-	-		FOG0001522
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100384
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X961
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.680