DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6512 and ftsh4

DIOPT Version :9

Sequence 1:	NP_730248.2	Gene:	CG6512 / 39922	FlyBaseID:	FBgn0036702	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_565616.1	Gene:	ftsh4 / 817154	AraportID:	AT2G26140	Length:	717	Species:	Arabidopsis thaliana

Alignment Length:	555	Identity:	224/555 - (40%)
Similarity:	324/555 - (58%)	Gaps:	64/555 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 IGFLVYMMRKSADMMGGG-----RG-RKGGGLFGGVMQSTAKLTNPNEIGVGFKDVAGCEEAKIE 339
            :|||:        :.|.|     || .||.||...|..|....|.       |.||.|.:|||.|
plant   189 VGFLL--------ISGIGALIEDRGIGKGLGLHEEVQPSMDSSTK-------FSDVKGVDEAKAE 238

  Fly   340 IMEFVNFLKNPQQYIDLGAKIPKGAMLTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGV 404
            :.|.|::|::|:::..||.|:|||.:|.||||||||:||:|.||||.|||.:.|||||.||||||
plant   239 LEEIVHYLRDPKRFTRLGGKLPKGVLLVGPPGTGKTMLARAIAGEAGVPFFSCSGSEFEEMFVGV 303

  Fly   405 GPSRVRDMFAMARKHAPCILFIDEIDAVGRKRGGKTFGGHSEQENTLNQLLVEMDGFNTTTNVVV 469
            |..||||:|:.|:|.:|||:|||||||:|..|..|   .....:.||||:|||:|||.....::|
plant   304 GARRVRDLFSAAKKCSPCIIFIDEIDAIGGSRNPK---DQQYMKMTLNQMLVELDGFKQNEGIIV 365

  Fly   470 LAATNRVDILDKALMRPGRFDRQIYVPAPDIKGRASIFKVHLGNLKTSLDKNELSRKMAALTPGF 534
            :||||..:.|||||:|||||||.|.||.||::||..|.:.|:..:..:.|.:.:.  :|..||||
plant   366 VAATNFPESLDKALVRPGRFDRHIVVPNPDVEGRRQILESHMSKVLKAEDVDLMI--IARGTPGF 428

  Fly   535 TGADIANVCNEAALIAARDSKDSIVLKHFEQAIERVIAGMEKKTNVLAPEEKRTVAHHEAGHAVA 599
            :|||:||:.|.|||.||.|....:.:...|.|.:|::.|.|:|:.|::.|.::..|.||.|||:.
plant   429 SGADLANLVNVAALKAAMDGSKDVTMSDLEFAKDRIMMGSERKSAVISDESRKLTAFHEGGHALV 493

  Fly   600 GWFLEHADPLLKVSIIPRGKGLGYAQYLP-KDHYLLSKEQLFDRMCMTLGGRVAEELFF--NRIT 661
            ....|.|.|:.|.:|:|||..||....|| ||...:|::|:..|:.:.:||||||||.|  :.:|
plant   494 AIHTEGALPVHKATIVPRGMALGMVSQLPDKDETSISRKQMLARLDVCMGGRVAEELIFGESEVT 558

  Fly   662 TGAQDDLKKITDIAYSQVVRFGMNEKVGQVSFDVGQAGDPVFSKPYSEDTAQLIDNEVRSIIKCA 726
            :||..||::.|.:|.:.|.:|||:::||.|:.:....|     |..|.:|..||::||:.:::.|
plant   559 SGASSDLEQATKLARAMVTKFGMSKEVGLVAHNYDDNG-----KSMSTETRLLIESEVKQLLEKA 618

  Fly   727 HEATTSLLTKHKENVQKVAERLLQNEVLSRDDMIELLGPRPFKEKSTYEEFVEGTGSFEEDTTLP 791
            :....::||.:.:.:..:|..|||:|.||...:.|||                        |.|.
plant   619 YNNAKTILTVYNKELHALANALLQHETLSGKQIKELL------------------------TDLN 659

  Fly   792 EGLKSWNKEKERTEPLDAGSTPSSPPTKPVTAQSS 826
            ..|.     ::|.|.:...|.| .||:.|.:|.|:
plant   660 SPLL-----QKRQEVVTKQSNP-VPPSTPSSASSA 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6512	NP_730248.2	FtsH_ext	163..259	CDD:284011
		FtsH_fam	271..764	CDD:273520	211/491 (43%)
		AAA	365..496	CDD:278434	79/130 (61%)
		Peptidase_M41	580..762	CDD:279742	66/184 (36%)
ftsh4	NP_565616.1	PRK09862	135..>282	CDD:182120	44/107 (41%)
ftsh4	NP_565616.1	FtsH_fam	221..655	CDD:273520	197/450 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D217929at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820