DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6512 and spg7

DIOPT Version :9

Sequence 1:	NP_730248.2	Gene:	CG6512 / 39922	FlyBaseID:	FBgn0036702	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	XP_001923118.1	Gene:	spg7 / 794740	ZFINID:	ZDB-GENE-030131-5391	Length:	788	Species:	Danio rerio

Alignment Length:	721	Identity:	305/721 - (42%)
Similarity:	422/721 - (58%)	Gaps:	81/721 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 FSNSSRGPAGKGGNSLGGRPLGENGGGGDRER---------------WILLGAIGAVVLVGSFAF 180
            ||.|:|....|.|.. |..|..|......||:               .:::..:.::...|.
Zfish    94 FSTSNRKHENKQGGK-GKTPEEEEEEKKRREQEDQMYRERLRTLFIIAVIMSLLNSINTSGG--- 154

  Fly   181 FEMGYKEISWKEFVNSYLSKGVVEKLEVV-NKKWVRVRLQQNSNSGSGVLWF-----------NI 233
                  .|||.:|||..|:||.|.:::|| ....|.:.|.      .|.:.|           .:
Zfish   155 ------NISWNDFVNEMLAKGEVSRVQVVPESDIVEIYLH------PGAVIFGRPRLALMYRMQV 207

  Fly   234 GSVDSFERNLEAAQTEQGTESINFVPVIYRNEVEAASLTGLLPTLLI--------IGFLVYMMRK 290
            .::|.||..|.||:.|...::.:.:||.|:.       ||.....|.        :..|.|:.|
Zfish   208 ANIDKFEEKLRAAEEELNIDAKDRIPVTYKR-------TGFFGNALYALGMAAIGVAILWYIFR- 264

  Fly   291 SADMMGGGRGRKGGGLFGGVMQ-STAKLT---NPNEIGVGFKDVAGCEEAKIEIMEFVNFLKNPQ 351
                :.|..||.||  |....| ..||.|   ..:..||.||||||..|||:|:.|||::||||.
Zfish   265 ----LAGMGGRDGG--FSAFNQLKMAKFTIVDGKSGKGVSFKDVAGMREAKMEVKEFVDYLKNPD 323

  Fly   352 QYIDLGAKIPKGAMLTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPSRVRDMFAMA 416
            :|:.||||:|||::|.||||.||||||||.|.||.|||:.::||||:|:..|:|.:|||.:|..|
Zfish   324 RYLQLGAKVPKGSLLLGPPGCGKTLLAKAVATEAQVPFLAMAGSEFVEVIGGLGAARVRSLFKEA 388

  Fly   417 RKHAPCILFIDEIDAVGRKRGGKTFG-GHSEQENTLNQLLVEMDGFNTTTNVVVLAATNRVDILD 480
            |..||||::||||||||:||.....| .::|:|.|||||||||||..||.:|:|||:|||.||||
Zfish   389 RARAPCIVYIDEIDAVGKKRSTNMSGFSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILD 453

  Fly   481 KALMRPGRFDRQIYVPAPDIKGRASIFKVHLGNLKTSLDKNELSRKMAALTPGFTGADIANVCNE 545
            .|||||||.||.|::..|.::.|..||:.||..||.:...:..|.::|.|||||:||||||:|||
Zfish   454 NALMRPGRLDRHIFIDLPTLQERKEIFEQHLKILKLTQPADFYSLRLAELTPGFSGADIANICNE 518

  Fly   546 AALIAARDSKDSIVLKHFEQAIERVIAGMEKKTNVLAPEEKRTVAHHEAGHAVAGWFLEHADPLL 610
            |||.|||:...||....||.|:||||||..||:.:|:.||:|.||.||:|||:.||.|||.:.::
Zfish   519 AALHAAREGFKSIDTFSFEYAVERVIAGSVKKSKILSKEEQRVVAFHESGHALVGWLLEHTEAVM 583

  Fly   611 KVSIIPR-GKGLGYAQYLPKDHYLLSKEQLFDRMCMTLGGRVAEELFFNRITTGAQDDLKKITDI 674
            ||||.|| ...||:||.||:|.:|.:|||||:||||.||||.:|.:.||::||||||||:|:|.:
Zfish   584 KVSIAPRTNAALGFAQILPRDQFLFTKEQLFERMCMALGGRASEAITFNKVTTGAQDDLRKVTRV 648

  Fly   675 AYSQVVRFGMNEKVGQVSFDVGQAGDPVFSKPYSEDTAQLIDNEVRSIIKCAHEATTSLLTKHKE 739
            |||.|.::||.:.||||||...:....:..:|:|:...|.:|.|.:.:|..|:..|..||..:::
Zfish   649 AYSMVKQYGMVDSVGQVSFPDSENQSGIGRRPFSQGLQQQMDLEAKMLIAKAYRHTEKLLLDNRD 713

  Fly   740 NVQKVAERLLQNEVLSRDDMIELLGPRPFKEKSTY--------EEFVEGTGSFEEDTTLPEGLKS 796
            .:..:|..||:.||::.:|:..||||.||..|...        |..::.||  |::...|:....
Zfish   714 KLILLANALLEREVVNYNDIEALLGPPPFGPKRMIAPQSWVEAERDLQDTG--EDEPRRPQRPSK 776

  Fly   797 WNKEKE 802
            .||:.:
Zfish   777 DNKDDD 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6512	NP_730248.2	FtsH_ext	163..259	CDD:284011	24/107 (22%)
		FtsH_fam	271..764	CDD:273520	254/506 (50%)
		AAA	365..496	CDD:278434	83/131 (63%)
		Peptidase_M41	580..762	CDD:279742	84/182 (46%)
spg7	XP_001923118.1	FtsH_ext	136..233	CDD:284011	24/111 (22%)
		FtsH_fam	257..738	CDD:273520	251/487 (52%)
		AAA	337..470	CDD:278434	83/132 (63%)
		Peptidase_M41	552..736	CDD:279742	84/183 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119497at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820