DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6512 and afg3l2

DIOPT Version :9

Sequence 1:	NP_730248.2	Gene:	CG6512 / 39922	FlyBaseID:	FBgn0036702	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_001072759.1	Gene:	afg3l2 / 780216	XenbaseID:	XB-GENE-944392	Length:	807	Species:	Xenopus tropicalis

Alignment Length:	774	Identity:	490/774 - (63%)
Similarity:	574/774 - (74%)	Gaps:	68/774 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LCKKPPKGFEKYFEAGGKSSGQPKGSVGDKKPPAGSSKSASEKPSTSTPASVKPSRSQTDAKSDW 126
            |..:|||||||||         |.|..|.|   |..||        .|.:.:|      |||
Frog    62 LTSQPPKGFEKYF---------PNGKNGKK---ANDSK--------GTSSGLK------DAK--- 97

  Fly   127 NFGMFSNSSRGPAGKGGNSLGGRPLGENGGGG---------------------DRE-RWILLGAI 169
                 .|.|:...|...||.||   |:.||.|                     |:| |:..:.:.
Frog    98 -----RNDSQQSTGGNSNSGGG---GKRGGKGSGKKEDSTWWSRLQKGEIPWDDKEFRFYFMASA 154

  Fly   170 GAVVLVGSFAFFEMGYKEISWKEFVNSYLSKGVVEKLEVVNKKWVRVRLQQNSNSGSG-VLWFNI 233
            |....|..:.||....:||:||:|.|:||||.:|::||||||::|||......:...| .:||||
Frog   155 GFWASVTYYFFFRNSGREITWKDFFNNYLSKDMVDRLEVVNKRFVRVIFTPGKSPVDGRYVWFNI 219

  Fly   234 GSVDSFERNLEAAQTEQGTESINFVPVIYRNEVEAASLTGLLPTLLIIGFLVYMMRKSADMMGGG 298
            ||||:||||||..|.|.|.|..|.:||:|.:|.:.:.|..:|||:||||||:|.:|:..  .|..
Frog   220 GSVDTFERNLETVQQELGIEGENRIPVVYSSESDGSFLLSMLPTVLIIGFLLYTLRRGP--AGAR 282

  Fly   299 RGRKGGGLFGGVMQSTAKLTNPNEIGVGFKDVAGCEEAKIEIMEFVNFLKNPQQYIDLGAKIPKG 363
            :||..|||| .|.::|||:.. :||.|.|||||||||||:||||||||||||:||.|||||||||
Frog   283 QGRGMGGLF-SVGETTAKVLK-DEIDVKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKG 345

  Fly   364 AMLTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPSRVRDMFAMARKHAPCILFIDE 428
            |:|||||||||||||||||||||||||||:|||||||||||||:||||:|.:|||:|||||||||
Frog   346 AVLTGPPGTGKTLLAKATAGEANVPFITVNGSEFLEMFVGVGPARVRDLFVLARKNAPCILFIDE 410

  Fly   429 IDAVGRKRGGKTFGGHSEQENTLNQLLVEMDGFNTTTNVVVLAATNRVDILDKALMRPGRFDRQI 493
            |||||||||...|||.|||||||||||||||||||||||||||.|||.||||.||:|||||||||
Frog   411 IDAVGRKRGRGNFGGQSEQENTLNQLLVEMDGFNTTTNVVVLAGTNRPDILDPALLRPGRFDRQI 475

  Fly   494 YVPAPDIKGRASIFKVHLGNLKT--SLDKNELSRKMAALTPGFTGADIANVCNEAALIAARDSKD 556
            |:..||||||||||||||..||.  :::|..|:||:|||||||:|||||||||||||||||...|
Frog   476 YIGPPDIKGRASIFKVHLRPLKLDGAIEKESLARKLAALTPGFSGADIANVCNEAALIAARHLSD 540

  Fly   557 SIVLKHFEQAIERVIAGMEKKTNVLAPEEKRTVAHHEAGHAVAGWFLEHADPLLKVSIIPRGKGL 621
            :|..||||.||||||.|:||||.||.||||:|||:||||||||||||||||||||||||||||||
Frog   541 AINQKHFEHAIERVIGGLEKKTQVLQPEEKKTVAYHEAGHAVAGWFLEHADPLLKVSIIPRGKGL 605

  Fly   622 GYAQYLPKDHYLLSKEQLFDRMCMTLGGRVAEELFFNRITTGAQDDLKKITDIAYSQVVRFGMNE 686
            ||||||||:.||.:||||.|||||||||||:|::||.||||||||||||:|..||:|:|:|||||
Frog   606 GYAQYLPKEQYLYTKEQLLDRMCMTLGGRVSEQIFFGRITTGAQDDLKKVTQSAYAQIVQFGMNE 670

  Fly   687 KVGQVSFDVGQAGDPVFSKPYSEDTAQLIDNEVRSIIKCAHEATTSLLTKHKENVQKVAERLLQN 751
            ||||||||:.:.||.|..|||||.||:|||:|||.:|..|:|.|.:|||:.|.:::|:|.|||:.
Frog   671 KVGQVSFDLPRQGDMVLEKPYSEATARLIDDEVRVLINTAYERTLTLLTEKKADIEKIALRLLEK 735

  Fly   752 EVLSRDDMIELLGPRPFKEKSTYEEFVEGTGSFEEDTTLPEGLKSWNK--EKERTEPLD 808
            |||.:.||:||||.|||.||||||||||||||.:|||:||||||.|||  ||||.:..|
Frog   736 EVLDKSDMVELLGKRPFAEKSTYEEFVEGTGSLDEDTSLPEGLKDWNKDREKERDDSSD 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6512	NP_730248.2	FtsH_ext	163..259	CDD:284011	44/96 (46%)
		FtsH_fam	271..764	CDD:273520	370/494 (75%)
		AAA	365..496	CDD:278434	115/130 (88%)
		Peptidase_M41	580..762	CDD:279742	131/181 (72%)
afg3l2	NP_001072759.1	FtsH_ext	148..245	CDD:377663	44/96 (46%)
afg3l2	NP_001072759.1	FtsH_fam	256..748	CDD:273520	370/495 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	275	1.000	Domainoid score	I1723
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4947
Inparanoid	1	1.050	903	1.000	Inparanoid score	I371
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119497at33208
OrthoFinder	1	1.000	-	-		FOG0001522
OrthoInspector	1	1.000	-	-		otm47446
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X961
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060