DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6512 and BCS1L

DIOPT Version :9

Sequence 1:	NP_730248.2	Gene:	CG6512 / 39922	FlyBaseID:	FBgn0036702	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_001073335.1	Gene:	BCS1L / 617	HGNCID:	1020	Length:	419	Species:	Homo sapiens

Alignment Length:	335	Identity:	80/335 - (23%)
Similarity:	126/335 - (37%)	Gaps:	98/335 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 SYL---SKGVVEKLEVV----------NKKWVRVRLQQNSNSGSGVLWFNIGSVDSFERNLEAAQ 247
            |||   |..:..|.|.|          ..||:||..                     .|.::...
Human    82 SYLQHESGRISTKFEFVPSPGNHFIWYRGKWIRVER---------------------SREMQMID 125

  Fly   248 TEQGT--ESINFVPV-----IYRNEVEAASLTGLLPTLLIIGFLVYMMRKSADMMGGGRGRKGGG 305
            .:.||  ||:.|..:     ::.|.:|.|....|...   .|..|......::....|..|:...
Human   126 LQTGTPWESVTFTALGTDRKVFFNILEEARELALQQE---EGKTVMYTAVGSEWRPFGYPRRRRP 187

  Fly   306 LFGGVMQSTAKLTNPNEIGVGFKDVAGCEEAKIEIMEFVNFLKNPQQYIDLGAKIPKGAMLTGPP 370
            |...|:|.          |:..:.|...:|          |:.||:.|.|.|....:|.:|.|||
Human   188 LNSVVLQQ----------GLADRIVRDVQE----------FIDNPKWYTDRGIPYRRGYLLYGPP 232

  Fly   371 GTGKTLLAKATAGEA--NVPFITVSGSEFLEMFVGVGPSRVRDMFAMARKHAPCILFIDEIDAVG 433
            |.||:....|.|||.  ::..::::.|       .:...|:..:.::|.:.:  ::.::::||..
Human   233 GCGKSSFITALAGELEHSICLLSLTDS-------SLSDDRLNHLLSVAPQQS--LVLLEDVDAAF 288

  Fly   434 RKR-------------GGKTFGGHSEQENTLNQLLVEMDGFNTTTNVVVLAATNRVDILDKALMR 485
            ..|             |..||.|          ||..:||..:|...:|...||.||.||.||:|
Human   289 LSRDLAVENPVKYQGLGRLTFSG----------LLNALDGVASTEARIVFMTTNHVDRLDPALIR 343

  Fly   486 PGRFDRQIYV 495
            |||.|.:.||
Human   344 PGRVDLKEYV 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6512	NP_730248.2	FtsH_ext	163..259	CDD:284011	17/77 (22%)
		FtsH_fam	271..764	CDD:273520	60/240 (25%)
		AAA	365..496	CDD:278434	42/146 (29%)
		Peptidase_M41	580..762	CDD:279742
BCS1L	NP_001073335.1	BCS1_N	24..191	CDD:214980	26/132 (20%)
BCS1L	NP_001073335.1	RecA-like_BCS1	201..353	CDD:410918	49/180 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900