Protein Alignment Afg3l2 and PSMC5

DIOPT Version :10

• Sequence 1: NP_730248.2
• Gene: Afg3l2 / 39922
• FlyBaseID: FBgn0036702
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: NP_002796.4
• Gene: PSMC5 / 5705
• HGNCID: 9552
• Length: 406
• Species: Homo sapiens
• Alignment Length: 417
• Identity: 130/417 - (31%)
• Similarity: 204/417 - (48%)
• Gaps: 102/417 - (24%)

  Fly   220 QNSNSGSGVLWFNIGSVDSFE-------RNLEAAQTEQGTESINFVPVIYRNEVEAASLTGLLPT 277
            :...:|||:..:.:..::..:       :||...|.:             |||:.|.
Human    12 EEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQ-------------RNELNAK-------- 55

  Fly   278 LLIIGFLVYMMRKSADMMGGGRGRKGGGLFGGVMQSTAK-------------------------- 316
                   |.::|:...::     ::.|...|.|:::..|
Human    56 -------VRLLREELQLL-----QEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDV 108

  Fly   317 -------LTN---------PNEI-------------GVGFKDVAGCEEAKIEIMEFVNF-LKNPQ 351
                   |.|         ||::             ...::.:.|.::...||.|.:.. :|:|:
Human   109 TPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPE 173

  Fly   352 QYIDLGAKIPKGAMLTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPSRVRDMFAMA 416
            .:..||...|||.:|.|||||||||||:|.|...:..||.|||||.::.|:|.|...||::|.||
Human   174 LFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMA 238

  Fly   417 RKHAPCILFIDEIDAVGRKR--GGKTFGGHSEQENTLNQLLVEMDGFNTTTNVVVLAATNRVDIL 479
            |:|||.|:|:||||::|..|  ||.  ||.||.:.|:.:||.::|||..|.|:.|:.||||:|||
Human   239 REHAPSIIFMDEIDSIGSSRLEGGS--GGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDIL 301

  Fly   480 DKALMRPGRFDRQIYVPAPDIKGRASIFKVHLGNLKTSLDKNELSRKMAALTPGFTGADIANVCN 544
            |.||:||||.||:|..|.|:.:.|..|.|:|  :.|.:|.:....||:|.|.||.:||::..||.
Human   302 DSALLRPGRIDRKIEFPPPNEEARLDILKIH--SRKMNLTRGINLRKIAELMPGASGAEVKGVCT 364

  Fly   545 EAALIAARDSKDSIVLKHFEQAIERVI 571
            ||.:.|.|:.:..:..:.||.|:.:|:
Human   365 EAGMYALRERRVHVTQEDFEMAVAKVM 391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Afg3l2	NP_730248.2	HflB	168..765	CDD:440233	130/417 (31%)
PSMC5	NP_002796.4	PRK03992	24..400	CDD:179699	127/405 (31%)
		May mediate interaction with PRPF9. /evidence=ECO:0000250|UniProtKB:P62196	186..406		99/210 (47%)