DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6512 and afg3l1

DIOPT Version :9

Sequence 1:	NP_730248.2	Gene:	CG6512 / 39922	FlyBaseID:	FBgn0036702	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	XP_005163264.1	Gene:	afg3l1 / 570430	ZFINID:	ZDB-GENE-121214-51	Length:	751	Species:	Danio rerio

Alignment Length:	735	Identity:	472/735 - (64%)
Similarity:	568/735 - (77%)	Gaps:	38/735 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 KSASEKPSTSTPASVKPSRS------------QTDAKSDWNFGMFSNSSRGPAGKGGNSLGGR-- 149
            :|.:..|..|....|.|.||            .|||..|         :..|.|.||...|||
Zfish    25 RSCAAHPPFSGLYGVSPLRSVGKRFTFPQSCYSTDAPKD---------APPPGGGGGGRRGGRKS 80

  Fly   150 -PLGENGGG---GDRE-RWILLGAIGAVVLVGSFAFFEMGYKEISWKEFVNSYLSKGVVEKLEVV 209
             |.....|.   .||: |.:||.|.|...|:....|.:.| |||:||:||:.||.:|:||:||||
Zfish    81 WPARLAQGDFPWDDRDFRHLLLAASGVAALLLYLLFRDPG-KEITWKDFVHRYLDRGLVERLEVV 144

  Fly   210 NKKWVRVRLQQNSNSGSG-VLWFNIGSVDSFERNLEAAQTEQGTESINFVPVIYRNEVEAASLTG 273
            ||::|||.|::::::..| .:||||||||:||||||||..|.|.|..:...|:|.:|.:.:.|..
Zfish   145 NKQFVRVILERDADANEGSYVWFNIGSVDTFERNLEAAHYELGLEPSHRAAVVYTSESDGSFLMS 209

  Fly   274 LLPTLLIIGFLVYMMRKSADMMGGGRGRKGGGLFGGVMQSTAKLTNPNEIGVGFKDVAGCEEAKI 338
            .:||||:||||::.:|:..  ||||.|.:.|||| |:.:||||:.. :.|.|.|||||||||||:
Zfish   210 FIPTLLLIGFLLFTLRRGP--MGGGMGGRRGGLF-GMSESTAKMMK-DSIEVKFKDVAGCEEAKV 270

  Fly   339 EIMEFVNFLKNPQQYIDLGAKIPKGAMLTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVG 403
            |||||||||||||||.||||||||||:|:|||||||||||||||||||||||||:||||||||||
Zfish   271 EIMEFVNFLKNPQQYQDLGAKIPKGAVLSGPPGTGKTLLAKATAGEANVPFITVNGSEFLEMFVG 335

  Fly   404 VGPSRVRDMFAMARKHAPCILFIDEIDAVGRKRGGKTFGGHSEQENTLNQLLVEMDGFNTTTNVV 468
            |||:|||||||:|||:||||||||||||||:||||..|||:||||||||||||||||||::||||
Zfish   336 VGPARVRDMFALARKNAPCILFIDEIDAVGKKRGGGNFGGNSEQENTLNQLLVEMDGFNSSTNVV 400

  Fly   469 VLAATNRVDILDKALMRPGRFDRQIYVPAPDIKGRASIFKVHLGNLK--TSLDKNELSRKMAALT 531
            |||.|||.|:||.|||||||||||||:..||||||||||||||..||  .|:|::.::|||||.|
Zfish   401 VLAGTNRPDVLDPALMRPGRFDRQIYLGPPDIKGRASIFKVHLRPLKLDPSVDRDAIARKMAAAT 465

  Fly   532 PGFTGADIANVCNEAALIAARDSKDSIVLKHFEQAIERVIAGMEKKTNVLAPEEKRTVAHHEAGH 596
            |||||||||||||||||||||...:|:.:|||||||:|||.|:||||.||.|.||:|||:|||||
Zfish   466 PGFTGADIANVCNEAALIAARYLNESVSVKHFEQAIDRVIGGLEKKTQVLQPTEKKTVAYHEAGH 530

  Fly   597 AVAGWFLEHADPLLKVSIIPRGKGLGYAQYLPKDHYLLSKEQLFDRMCMTLGGRVAEELFFNRIT 661
            ||.||||:|||||||||||||||||||||||||:.||.::|||||||||.|||||||::|||:||
Zfish   531 AVVGWFLQHADPLLKVSIIPRGKGLGYAQYLPKEQYLYTREQLFDRMCMMLGGRVAEQVFFNKIT 595

  Fly   662 TGAQDDLKKITDIAYSQVVRFGMNEKVGQVSFDVGQAGDPVFSKPYSEDTAQLIDNEVRSIIKCA 726
            |||.|||||:|..||:|:|:|||:|:|||||||:.:.|:.|..|||||.||:|||.|||.::..|
Zfish   596 TGAHDDLKKVTQSAYAQIVQFGMSERVGQVSFDLPRQGETVLEKPYSEATAELIDEEVRDLVDRA 660

  Fly   727 HEATTSLLTKHKENVQKVAERLLQNEVLSRDDMIELLGPRPFKEKSTYEEFVEGTGSFEEDTTLP 791
            :..|..|:|:.:|.|..|.:|||:.|||.:.||:||||.|||:|||||||||||||||||||:||
Zfish   661 YRRTLELVTEKREQVDMVGKRLLEKEVLDKADMLELLGARPFEEKSTYEEFVEGTGSFEEDTSLP 725

  Fly   792 EGLKSWNKEK--ERTEPLDA 809
            ||||.||:|:  |..||.|:
Zfish   726 EGLKDWNQERRGEPEEPTDS 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6512	NP_730248.2	FtsH_ext	163..259	CDD:284011	49/96 (51%)
		FtsH_fam	271..764	CDD:273520	360/494 (73%)
		AAA	365..496	CDD:278434	114/130 (88%)
		Peptidase_M41	580..762	CDD:279742	121/181 (67%)
afg3l1	XP_005163264.1	FtsH_ext	100..191	CDD:284011	49/91 (54%)
		FtsH_fam	206..698	CDD:273520	360/495 (73%)
		AAA	298..428	CDD:278434	114/129 (88%)
		Peptidase_M41	514..696	CDD:279742	121/181 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573380
Domainoid	1	1.000	274	1.000	Domainoid score	I1741
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	916	1.000	Inparanoid score	I354
OMA	1	1.010	-	-		QHG57866
OrthoDB	1	1.010	-	-		D119497at33208
OrthoFinder	1	1.000	-	-		FOG0001522
OrthoInspector	1	1.000	-	-		otm25934
orthoMCL	1	0.900	-	-		OOG6_100384
Panther	1	1.100	-	-	LDO	PTHR43655
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2012
SonicParanoid	1	1.000	-	-		X961
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.840