DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6512 and afg3l2

DIOPT Version :9

Sequence 1:	NP_730248.2	Gene:	CG6512 / 39922	FlyBaseID:	FBgn0036702	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_001104667.1	Gene:	afg3l2 / 569168	ZFINID:	ZDB-GENE-070912-46	Length:	800	Species:	Danio rerio

Alignment Length:	833	Identity:	509/833 - (61%)
Similarity:	589/833 - (70%)	Gaps:	74/833 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAFRLLGTAKTMAGMMRRNYTAGSLPG-KGQRTHMGATGAGVYILPTELSPLLRYVVKQIQLLCK 64
            ||.|.|..::..     ||.....||. :.........|.|..:|  :...||..|:...:.|..
Zfish     1 MAHRYLHLSRGC-----RNLLHTLLPNVRSTNRFQSVQGVGQIVL--DRRSLLSQVLGTYRRLSS 58

  Fly    65 KPPKGFEKYFEAGGKSSGQPKGSVGDKKPPAGSSKSASEKPSTSTPASVKPSRSQTDAKSDWNFG 129
            ||||||||||.  ...:|.||.|              ...||.:.....||
Zfish    59 KPPKGFEKYFP--NNKNGGPKNS--------------EPTPSNAEVKEAKP-------------- 93

  Fly   130 MFSNSSRGPAGKGGNSLGGRPLGENGGGGDRERW------------------ILLGAIGAVVLVG 176
              :||.:...|.||.|.||   |:.||..|...|                  ..||.....:.:|
Zfish    94 --TNSQKTTGGGGGGSSGG---GKRGGRKDESTWQSRIQKGEFPWDDKEFRMYFLGGTAFWLAMG 153

  Fly   177 SFAFFEMGYKEISWKEFVNSYLSKGVVEKLEVVNKKWVRVRLQQNSNSGSG-VLWFNIGSVDSFE 240
            .:.|...|.:|::||:||||||:||||::||||||::|:|..........| .:||||||||:||
Zfish   154 YYFFIRDGGREVTWKDFVNSYLAKGVVDRLEVVNKRYVKVIFTPGKTPVDGQYVWFNIGSVDTFE 218

  Fly   241 RNLEAAQTEQGTESINFVPVIYRNEVEAASLTGLLPTLLIIGFLVYMMRKSADMMGGGR-GRKGG 304
            ||||.||.|.|.|..|.:||:|..|.:.:.|..:|||:||||||::|:|:..  .|.|| ||..|
Zfish   219 RNLETAQLELGIEGENRLPVVYSAESDGSFLLSMLPTVLIIGFLLFMLRRGP--AGAGRPGRGMG 281

  Fly   305 GLFGGVMQSTAKLTNPNEIGVGFKDVAGCEEAKIEIMEFVNFLKNPQQYIDLGAKIPKGAMLTGP 369
            ||| .|.::|||:.. :||.|.|||||||||||:||||||||||||:||.||||||||||:||||
Zfish   282 GLF-SVSETTAKVLR-DEIDVKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAILTGP 344

  Fly   370 PGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPSRVRDMFAMARKHAPCILFIDEIDAVGR 434
            |||||||||||||||||||||||:|||||||||||||:||||:|.:|||:|||||||||||||||
Zfish   345 PGTGKTLLAKATAGEANVPFITVNGSEFLEMFVGVGPARVRDLFVLARKNAPCILFIDEIDAVGR 409

  Fly   435 KRGGKTFGGHSEQENTLNQLLVEMDGFNTTTNVVVLAATNRVDILDKALMRPGRFDRQIYVPAPD 499
            |||...|||.|||||||||||||||||||.|||||||.|||.||||.|||||||||||||:..||
Zfish   410 KRGRGNFGGQSEQENTLNQLLVEMDGFNTATNVVVLAGTNRPDILDPALMRPGRFDRQIYIGPPD 474

  Fly   500 IKGRASIFKVHLGNLK--TSLDKNELSRKMAALTPGFTGADIANVCNEAALIAARDSKDSIVLKH 562
            ||||||||||||..||  ..|||..|:||||||||||:|||||||||||||||||...|:|..||
Zfish   475 IKGRASIFKVHLRPLKLEAELDKEALARKMAALTPGFSGADIANVCNEAALIAARHLSDAINQKH 539

  Fly   563 FEQAIERVIAGMEKKTNVLAPEEKRTVAHHEAGHAVAGWFLEHADPLLKVSIIPRGKGLGYAQYL 627
            |||||||||.|:||||.||.||||:|||:||||||||||||||||||||||||||||||||||||
Zfish   540 FEQAIERVIGGLEKKTQVLQPEEKKTVAYHEAGHAVAGWFLEHADPLLKVSIIPRGKGLGYAQYL 604

  Fly   628 PKDHYLLSKEQLFDRMCMTLGGRVAEELFFNRITTGAQDDLKKITDIAYSQVVRFGMNEKVGQVS 692
            ||:.||.:||||.|||||||||||:||:||.||||||||||||:|..||:|:|:|||||||||||
Zfish   605 PKEQYLYTKEQLLDRMCMTLGGRVSEEIFFGRITTGAQDDLKKVTQSAYAQIVQFGMNEKVGQVS 669

  Fly   693 FDVGQAGDPVFSKPYSEDTAQLIDNEVRSIIKCAHEATTSLLTKHKENVQKVAERLLQNEVLSRD 757
            ||:.:.|:.|..|||||.||:|||.|||::|..|:|.|..||:..|..|:|||.|||:.|||.::
Zfish   670 FDLPRQGELVLEKPYSEATARLIDTEVRNLISTAYERTQQLLSDKKPEVEKVALRLLEKEVLDKN 734

  Fly   758 DMIELLGPRPFKEKSTYEEFVEGTGSFEEDTTLPEGLKSWNKEK-----ERTE 805
            ||:||||.|||.||||||||||||||.:|||:||||||.||||:     |.||
Zfish   735 DMVELLGKRPFAEKSTYEEFVEGTGSVDEDTSLPEGLKDWNKERGSEKEESTE 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6512	NP_730248.2	FtsH_ext	163..259	CDD:284011	48/114 (42%)
		FtsH_fam	271..764	CDD:273520	377/495 (76%)
		AAA	365..496	CDD:278434	115/130 (88%)
		Peptidase_M41	580..762	CDD:279742	132/181 (73%)
afg3l2	NP_001104667.1	FtsH_ext	141..237	CDD:284011	47/95 (49%)
		FtsH_fam	248..741	CDD:273520	377/496 (76%)
		AAA	340..471	CDD:278434	115/130 (88%)
		Peptidase_M41	557..739	CDD:279742	132/181 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	274	1.000	Domainoid score	I1741
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4947
Inparanoid	1	1.050	916	1.000	Inparanoid score	I354
OMA	1	1.010	-	-		QHG57866
OrthoDB	1	1.010	-	-		D119497at33208
OrthoFinder	1	1.000	-	-		FOG0001522
OrthoInspector	1	1.000	-	-		otm25934
orthoMCL	1	0.900	-	-		OOG6_100384
Panther	1	1.100	-	-	O	PTHR43655
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2012
SonicParanoid	1	1.000	-	-		X961
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.010