DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6512 and afg3l1p

DIOPT Version :9

Sequence 1:	NP_730248.2	Gene:	CG6512 / 39922	FlyBaseID:	FBgn0036702	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_001015906.1	Gene:	afg3l1p / 548660	XenbaseID:	XB-GENE-1014910	Length:	778	Species:	Xenopus tropicalis

Alignment Length:	748	Identity:	485/748 - (64%)
Similarity:	572/748 - (76%)	Gaps:	40/748 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 KPPKGFEKYFEAGGKSSGQPKGSVGDKKPPAGSSKSASEKPSTSTPASVKPSRSQTDAKSDWNFG 129
            ||||||||||:...|.||..|.|      |.|:. :|.|:.:..|.......|.....:|.|
Frog    59 KPPKGFEKYFQKNEKDSGSGKAS------PEGTG-NAKEEETKKTSGGHNNRRDGNKEESAW--- 113

  Fly   130 MFSNSSRGPAGKGGNSLGGRPLGENGGGGDRERWILLGAIGAVVLVGSFAFF---EMGYKEISWK 191
                              .|.|.:.....|.:.:..|..:.|.:..| |.||   :.| :||:||
Frog   114 ------------------WRRLQKGDFPWDDKDFRNLAILAAGIASG-FLFFYLRDPG-REINWK 158

  Fly   192 EFVNSYLSKGVVEKLEVVNKKWVRVRLQQNSNSGSGVLWFNIGSVDSFERNLEAAQTEQGTESIN 256
            |||:.||::|||::||||||::||| :.....:....:|||||||||||||||.||.|.|.|...
Frog   159 EFVHLYLARGVVDRLEVVNKQFVRV-IPTAGTTSEKYVWFNIGSVDSFERNLENAQDELGIEPAQ 222

  Fly   257 FVPVIYRNEVEAASLTGLLPTLLIIGFLVYMMRKSADMMGGGRGRKGGGLFGGVMQSTAKLTNPN 321
            .|.|||.:|.:.:.|..|:||||::|||::.:|:.|  ||.|||.:||||| ||.::|||:...|
Frog   223 RVSVIYSSESDGSFLMSLIPTLLLVGFLLFSLRRGA--MGPGRGGRGGGLF-GVGETTAKMLKGN 284

  Fly   322 EIGVGFKDVAGCEEAKIEIMEFVNFLKNPQQYIDLGAKIPKGAMLTGPPGTGKTLLAKATAGEAN 386
             |.|.|||||||||||:||||||||||||:||.|||||||:||||||||||||||||||||||||
Frog   285 -IDVKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPRGAMLTGPPGTGKTLLAKATAGEAN 348

  Fly   387 VPFITVSGSEFLEMFVGVGPSRVRDMFAMARKHAPCILFIDEIDAVGRKRGGKTFGGHSEQENTL 451
            ||||||:|||||||||||||:|||||||||||:||||||||||||||||||...|||.|||||||
Frog   349 VPFITVNGSEFLEMFVGVGPARVRDMFAMARKNAPCILFIDEIDAVGRKRGRGNFGGQSEQENTL 413

  Fly   452 NQLLVEMDGFNTTTNVVVLAATNRVDILDKALMRPGRFDRQIYVPAPDIKGRASIFKVHLGNLK- 515
            |||||||||||::||||:||.|||.||||.|||||||||||||:..||||||||||||||..||
Frog   414 NQLLVEMDGFNSSTNVVILAGTNRPDILDPALMRPGRFDRQIYIGPPDIKGRASIFKVHLRPLKL 478

  Fly   516 -TSLDKNELSRKMAALTPGFTGADIANVCNEAALIAARDSKDSIVLKHFEQAIERVIAGMEKKTN 579
             .|:.|..||||:|||||||||||||||||||||||||..||.:|.|||.|||||||.|:||||.
Frog   479 DESVSKEALSRKLAALTPGFTGADIANVCNEAALIAARYLKDYVVEKHFVQAIERVIGGLEKKTQ 543

  Fly   580 VLAPEEKRTVAHHEAGHAVAGWFLEHADPLLKVSIIPRGKGLGYAQYLPKDHYLLSKEQLFDRMC 644
            ||.||||:|||:|||||||.||:|:|||||||||||||||||||||||||:.||.::||||||||
Frog   544 VLQPEEKKTVAYHEAGHAVVGWYLQHADPLLKVSIIPRGKGLGYAQYLPKEQYLYTREQLFDRMC 608

  Fly   645 MTLGGRVAEELFFNRITTGAQDDLKKITDIAYSQVVRFGMNEKVGQVSFDVGQAGDPVFSKPYSE 709
            |.|||||:|:|||:||||||||||||:|..||:|:|:|||:||:||||||:.:.|:.:..|||||
Frog   609 MMLGGRVSEQLFFSRITTGAQDDLKKVTQSAYAQIVQFGMSEKLGQVSFDLPRQGEMLAEKPYSE 673

  Fly   710 DTAQLIDNEVRSIIKCAHEATTSLLTKHKENVQKVAERLLQNEVLSRDDMIELLGPRPFKEKSTY 774
            .||:|||.|.|::|..|:|.|..|||:.|:.|:|||:|||:.|||.:.|||||||.|||.|||:|
Frog   674 ATAELIDQEARNLINSAYERTLELLTRCKDQVEKVAKRLLEKEVLEKSDMIELLGARPFPEKSSY 738

  Fly   775 EEFVEGTGSFEEDTTLPEGLKSWNKEKERTEPL 807
            |||||||||.||||:||||||.||:|:|..:.|
Frog   739 EEFVEGTGSLEEDTSLPEGLKDWNQEREDEQEL 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6512	NP_730248.2	FtsH_ext	163..259	CDD:284011	48/98 (49%)
		FtsH_fam	271..764	CDD:273520	373/494 (76%)
		AAA	365..496	CDD:278434	117/130 (90%)
		Peptidase_M41	580..762	CDD:279742	126/181 (70%)
afg3l1p	NP_001015906.1	FtsH_ext	133..223	CDD:377663	47/92 (51%)
afg3l1p	NP_001015906.1	FtsH_fam	236..728	CDD:273520	373/495 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	275	1.000	Domainoid score	I1723
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	903	1.000	Inparanoid score	I371
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119497at33208
OrthoFinder	1	1.000	-	-		FOG0001522
OrthoInspector	1	1.000	-	-		otm47446
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X961
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060