DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6512 and Spg7

DIOPT Version :9

Sequence 1:	NP_730248.2	Gene:	CG6512 / 39922	FlyBaseID:	FBgn0036702	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	XP_008770841.1	Gene:	Spg7 / 353231	RGDID:	727940	Length:	781	Species:	Rattus norvegicus

Alignment Length:	822	Identity:	324/822 - (39%)
Similarity:	452/822 - (54%)	Gaps:	125/822 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 GSLPGKGQR-------THMGATGAGVYILPTELSPLLRYVVKQIQ----LLCKK---PP------ 67
            |...|.|.|       |.:|...||.:   |..|.|||.:....:    ||.|:   |.
  Rat    32 GLFSGAGGRRPYVVRGTPIGLAAAGGH---TPQSLLLRILTPSFEGVSGLLLKRHIVPSAIRLWQ 93

  Fly    68 -KGFEKYFEAGG-----KSSGQPKGSVGDKKPPAGSSKSASEKPSTSTPASVKPSRSQTDAKSDW 126
             .|...||...|     |...:|||     |.|....:....|                 .:.|.
  Rat    94 LSGSTLYFNTSGLKQKNKDDDKPKG-----KAPEDDEEERRRK-----------------EREDQ 136

  Fly   127 NFGMFSNSSRGPAGKGGNSLGGRPLGENGGGGDRERWILLGAIGAVV-LVGSFAFFEMGYKEISW 190
            .:                               |||...|..|..|: |:.|.:   .....|||
  Rat   137 MY-------------------------------RERLRTLFIIAIVMSLLNSLS---TSGGSISW 167

  Fly   191 KEFVNSYLSKGVVEKLEVV-NKKWVRVRLQQNSNSGSGVLWF-----------NIGSVDSFERNL 243
            .:|||..|:||.|::::|| ....|.|.|.      .|.:.|           .:.::|.||..|
  Rat   168 ADFVNEMLAKGEVQRVQVVPESDVVEVYLH------PGAVVFGRPRLALMYRMQVANIDKFEEKL 226

  Fly   244 EAAQTEQGTESINFVPVIY-RNEVEAASLTGLLPTLLIIGFLVYMMRKSADMMGGGRGRKGGGLF 307
            .||:.|...||.:.:||.| |......:|..|..|.:.:..|.|:.|     :.|..||:||  |
  Rat   227 RAAEDELNIESKDRIPVSYKRTGFFGNALYALGMTAVGLAILWYVFR-----LAGMTGREGG--F 284

  Fly   308 GGVMQ-STAKLT---NPNEIGVGFKDVAGCEEAKIEIMEFVNFLKNPQQYIDLGAKIPKGAMLTG 368
            ....| ..|:.|   .....||.|:||||..|||:|:.|||::||:|::::.||||:||||:|.|
  Rat   285 SAFNQLKMARFTIVDGKTGKGVSFQDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLG 349

  Fly   369 PPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPSRVRDMFAMARKHAPCILFIDEIDAVG 433
            |||.||||||||.|.||.|||:.::|.||:|:..|:|.:|||.:|..||..||||::||||||||
  Rat   350 PPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVG 414

  Fly   434 RKRGGKTFG-GHSEQENTLNQLLVEMDGFNTTTNVVVLAATNRVDILDKALMRPGRFDRQIYVPA 497
            :||.....| .::|:|.|||||||||||..|..:|:|||:|||.|:||.|||||||.||.:::..
  Rat   415 KKRSTSMSGFSNTEEEQTLNQLLVEMDGMGTADHVIVLASTNRADVLDNALMRPGRLDRHVFIDL 479

  Fly   498 PDIKGRASIFKVHLGNLKTSLDKNELSRKMAALTPGFTGADIANVCNEAALIAARDSKDSIVLKH 562
            |.::.|..||:.||..||.:...:..|:::|.|||||:||||||:||||||.|||:...|:...:
  Rat   480 PTLQERREIFEQHLKGLKLTQPSSFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSVHTFN 544

  Fly   563 FEQAIERVIAGMEKKTNVLAPEEKRTVAHHEAGHAVAGWFLEHADPLLKVSIIPR-GKGLGYAQY 626
            ||.|:||||||..||:.:|:.||:|.||.||:|||:.||.|||.:.::||||.|| ...||::|.
  Rat   545 FEYAVERVIAGTAKKSKILSKEEQRVVAFHESGHALVGWLLEHTEAVMKVSIAPRTNAALGFSQM 609

  Fly   627 LPKDHYLLSKEQLFDRMCMTLGGRVAEELFFNRITTGAQDDLKKITDIAYSQVVRFGMNEKVGQV 691
            ||:|.||.:|||||:||||.||||.||.:.|:|:|:||||||:|:|.||||.|.:|||...:|.|
  Rat   610 LPRDQYLFTKEQLFERMCMALGGRAAEAISFSRVTSGAQDDLRKVTRIAYSMVKQFGMAPSIGPV 674

  Fly   692 SFDVGQAG-DPVFSKPYSEDTAQLIDNEVRSIIKCAHEATTSLLTKHKENVQKVAERLLQNEVLS 755
            ||...|.| ..:..:|:|:...|::|:|.|.::..|:..|..:|..:.:.:|.:|..||:.||::
  Rat   675 SFPEAQEGLVGIGRRPFSQGLQQMMDHEARLLVARAYRHTEKVLLDNLDKLQALANALLEKEVIN 739

  Fly   756 RDDMIELLGPRPF--KEKSTYEEFV----EGTGSFEEDTTLP 791
            .:|:..|:||.|.  |:....::::    |...|.||:...|
  Rat   740 YEDIEALIGPPPHGPKKMIAPQKWIDAEKEKQASGEEEAPAP 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6512	NP_730248.2	FtsH_ext	163..259	CDD:284011	31/108 (29%)
		FtsH_fam	271..764	CDD:273520	248/499 (50%)
		AAA	365..496	CDD:278434	79/131 (60%)
		Peptidase_M41	580..762	CDD:279742	86/183 (47%)
Spg7	XP_008770841.1	FtsH_ext	145..242	CDD:310823	31/105 (30%)
Spg7	XP_008770841.1	TIP49	265..748	CDD:332389	245/489 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119497at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820