Protein Alignment Afg3l2 and Afg3l2

DIOPT Version :10

• Sequence 1: NP_730248.2
• Gene: Afg3l2 / 39922
• FlyBaseID: FBgn0036702
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: NP_001128336.1
• Gene: Afg3l2 / 307350
• RGDID: 1305259
• Length: 802
• Species: Rattus norvegicus
• Alignment Length: 802
• Identity: 492/802 - (61%)
• Similarity: 582/802 - (72%)
• Gaps: 98/802 - (12%)

  Fly    49 SPLLRYVVKQIQLLCKKPPKGFEKYFEAG--GKSSGQPKGSVGDKKPPAGSSKSASEKPSTSTPA 111
            |.|||.|:...|..|.:|||||||||..|  ||.:.:.|.:||:||
  Rat    52 SSLLRDVIAAYQRFCSRPPKGFEKYFPNGKNGKKASESKEAVGEKK------------------- 97

  Fly   112 SVKPSRSQTDAKSDWNFGMFSNSSRGPAGKGGNSLGGRPLGENGGGGDRE--------------- 161
                 .||..               ||...||.|         ||||.|.
  Rat    98 -----ESQLS---------------GPQSSGGAS---------GGGGKRRGKKEDSHWWSRFQKG 133

  Fly   162 -------------RWILLGAIGAVVLVGSFAFFEMGYKEISWKEFVNSYLSKGVVEKLEVVNKKW 213
                         .|..|...|.::    :..|:...:||:||:|||:|||||||::||||||::
  Rat   134 DFPWDDKDFRMYFLWTALFWSGVMI----YFLFKSSGREITWKDFVNNYLSKGVVDRLEVVNKRF 194

  Fly   214 VRVRLQQNSNSGSG-VLWFNIGSVDSFERNLEAAQTEQGTESINFVPVIYRNEVEAASLTGLLPT 277
            |||..........| .:||||||||:||||||..|.|.|.|..|.|||:|..|.:.:.|..:|||
  Rat   195 VRVTFTPGKTPVDGQYVWFNIGSVDTFERNLETLQQELGIEGENRVPVVYIAESDGSFLLSMLPT 259

  Fly   278 LLIIGFLVYMMRKSADMMGGGR-GRKGGGLFGGVMQSTAKLTNPNEIGVGFKDVAGCEEAKIEIM 341
            :|||.||:|.:|:..  .|.|| ||..|||| .|.::|||:.. :||.|.|||||||||||:|||
  Rat   260 VLIIAFLLYTIRRGP--AGIGRTGRGMGGLF-SVGETTAKVLK-DEIDVKFKDVAGCEEAKLEIM 320

  Fly   342 EFVNFLKNPQQYIDLGAKIPKGAMLTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGP 406
            |||||||||:||.||||||||||:|||||||||||||||||||||||||||||||||||||||||
  Rat   321 EFVNFLKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGP 385

  Fly   407 SRVRDMFAMARKHAPCILFIDEIDAVGRKRGGKTFGGHSEQENTLNQLLVEMDGFNTTTNVVVLA 471
            :||||:||:|||:||||||||||||||||||...|||.||||||||||||||||||||||||:||
  Rat   386 ARVRDLFALARKNAPCILFIDEIDAVGRKRGRGNFGGQSEQENTLNQLLVEMDGFNTTTNVVILA 450

  Fly   472 ATNRVDILDKALMRPGRFDRQIYVPAPDIKGRASIFKVHLGNLK--TSLDKNELSRKMAALTPGF 534
            .|||.||||.||:|||||||||::..||||||||||||||..||  ::|:|::|:||:|:|||||
  Rat   451 GTNRPDILDPALLRPGRFDRQIFIGPPDIKGRASIFKVHLRPLKLDSALEKDKLARKLASLTPGF 515

  Fly   535 TGADIANVCNEAALIAARDSKDSIVLKHFEQAIERVIAGMEKKTNVLAPEEKRTVAHHEAGHAVA 599
            :|||:|||||||||||||...|:|..|||||||||||.|:||||.||.||||:|||:||||||||
  Rat   516 SGADVANVCNEAALIAARHLSDAINEKHFEQAIERVIGGLEKKTQVLQPEEKKTVAYHEAGHAVA 580

  Fly   600 GWFLEHADPLLKVSIIPRGKGLGYAQYLPKDHYLLSKEQLFDRMCMTLGGRVAEELFFNRITTGA 664
            ||:|||||||||||||||||||||||||||:.||.:||||.|||||||||||:||:||.||||||
  Rat   581 GWYLEHADPLLKVSIIPRGKGLGYAQYLPKEQYLYTKEQLLDRMCMTLGGRVSEEIFFGRITTGA 645

  Fly   665 QDDLKKITDIAYSQVVRFGMNEKVGQVSFDVGQAGDPVFSKPYSEDTAQLIDNEVRSIIKCAHEA 729
            ||||:|:|..||:|:|:|||||||||:|||:.:.||.|..|||||.||::||:|||.:|..|::.
  Rat   646 QDDLRKVTQSAYAQIVQFGMNEKVGQISFDLPRQGDMVLEKPYSEATARMIDDEVRILISEAYKR 710

  Fly   730 TTSLLTKHKENVQKVAERLLQNEVLSRDDMIELLGPRPFKEKSTYEEFVEGTGSFEEDTTLPEGL 794
            |.:|||:.|.:|:|||..||:.|||.::||:||||||||.||||||||||||||.:|||:|||||
  Rat   711 TVALLTEKKADVEKVALLLLEKEVLDKNDMVELLGPRPFTEKSTYEEFVEGTGSLDEDTSLPEGL 775

  Fly   795 KSWNKE--------KERTEPLD 808
            :.||||        ||:.||::
  Rat   776 QDWNKEREKEKKEKKEKEEPVN 797

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Afg3l2	NP_730248.2	HflB	168..765	CDD:440233	419/600 (70%)
Afg3l2	NP_001128336.1	HflB	156..746	CDD:440233	413/621 (67%)