DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6512 and Spg7

DIOPT Version :9

Sequence 1:	NP_730248.2	Gene:	CG6512 / 39922	FlyBaseID:	FBgn0036702	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_694816.3	Gene:	Spg7 / 234847	MGIID:	2385906	Length:	781	Species:	Mus musculus

Alignment Length:	821	Identity:	322/821 - (39%)
Similarity:	455/821 - (55%)	Gaps:	125/821 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 RRNYTAGSLPGKGQRTHMGATGAGVYILPTELSPLLRYVVKQIQ----LLCKK----------PP 67
            ||.|.|...|       :|...||.: .|..|  |||.:....:    ||.|:          |.
Mouse    40 RRPYAARGTP-------VGPAAAGGH-APQSL--LLRILTPSFEGISGLLLKQHIVPNAVRLWPL 94

  Fly    68 KGFEKYFEAG-----GKSSGQPKGSVGDKKPPAGSSKSASEKPSTSTPASVKPSRSQTDAKSDWN 127
            .|...||...     .|.:.:|||                     .||...:..:.:.:.:..
Mouse    95 SGSTLYFNTSRMKQKNKDNDKPKG---------------------KTPEDDEEEKRRKEREDQ-- 136

  Fly   128 FGMFSNSSRGPAGKGGNSLGGRPLGENGGGGDRERWILLGAIGAVV-LVGSFAFFEMGYKEISWK 191
              |:                            |||...|..|..|: |:.|.:   .....|||.
Mouse   137 --MY----------------------------RERLRTLFIIALVMSLLNSLS---TSGGSISWA 168

  Fly   192 EFVNSYLSKGVVEKLEVV-NKKWVRVRLQQNSNSGSGVLWF-----------NIGSVDSFERNLE 244
            :|||..|:||.|::::|| ....|.|.|.      .|.:.|           .:.::|.||..|.
Mouse   169 DFVNEMLAKGEVQRVQVVPESDVVEVYLH------PGAVVFGRPRLALMYRMQVANIDKFEEKLR 227

  Fly   245 AAQTEQGTESINFVPVIY-RNEVEAASLTGLLPTLLIIGFLVYMMRKSADMMGGGRGRKGGGLFG 308
            ||:.|...||.:.:||.| |......:|..|..|.:.:..|.|:.|     :.|..||:||  |.
Mouse   228 AAEDELNIESKDRIPVSYKRTGFFGNALYALGMTAVGLAILWYVFR-----LAGMTGREGG--FS 285

  Fly   309 GVMQ-STAKLT---NPNEIGVGFKDVAGCEEAKIEIMEFVNFLKNPQQYIDLGAKIPKGAMLTGP 369
            ...| ..|:.|   .....||.|:||||..|||:|:.|||::||:|::::.||||:||||:|.||
Mouse   286 AFNQLKMARFTIVDGKTGKGVSFQDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGP 350

  Fly   370 PGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPSRVRDMFAMARKHAPCILFIDEIDAVGR 434
            ||.||||||||.|.||.|||:.::|.||:|:..|:|.:|||.:|..||..||||::||||||||:
Mouse   351 PGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGK 415

  Fly   435 KRGGKTFG-GHSEQENTLNQLLVEMDGFNTTTNVVVLAATNRVDILDKALMRPGRFDRQIYVPAP 498
            ||.....| .::|:|.|||||||||||..||.:|:|||:|||.|:||.|||||||.||.:::..|
Mouse   416 KRSTSMSGFSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADVLDNALMRPGRLDRHVFIDLP 480

  Fly   499 DIKGRASIFKVHLGNLKTSLDKNELSRKMAALTPGFTGADIANVCNEAALIAARDSKDSIVLKHF 563
            .::.|..||:.||..||.:...:..|:::|.|||||:||||||:||||||.|||:...|:...:|
Mouse   481 TLQERREIFEQHLKGLKLTQPSSFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSVHTFNF 545

  Fly   564 EQAIERVIAGMEKKTNVLAPEEKRTVAHHEAGHAVAGWFLEHADPLLKVSIIPR-GKGLGYAQYL 627
            |.|:||||||..||:.:|:.||:|.||.||:|||:.||.|||.:.::||||.|| ...||::|.|
Mouse   546 EYAVERVIAGTAKKSKILSKEEQRVVAFHESGHALVGWLLEHTEAVMKVSIAPRTNAALGFSQML 610

  Fly   628 PKDHYLLSKEQLFDRMCMTLGGRVAEELFFNRITTGAQDDLKKITDIAYSQVVRFGMNEKVGQVS 692
            |:|.||.:|||||:||||.||||.||.:.|:|:|:||||||:|:|.||||.|.:|||...:|.||
Mouse   611 PRDQYLFTKEQLFERMCMALGGRAAEAISFSRVTSGAQDDLRKVTRIAYSMVKQFGMAPSIGPVS 675

  Fly   693 FDVGQAG-DPVFSKPYSEDTAQLIDNEVRSIIKCAHEATTSLLTKHKENVQKVAERLLQNEVLSR 756
            |...|.| ..:..:|:|:...|::|:|.:.::..|:..|..:|..:.:.:|.:|..||:.||::.
Mouse   676 FPEAQEGLMGIGRRPFSQGLQQMMDHEAKLLVAKAYRHTEKVLLDNLDKLQALANALLEKEVINY 740

  Fly   757 DDMIELLGPRPF--KEKSTYEEFV----EGTGSFEEDTTLP 791
            :|:..|:||.|.  |:....::::    |...|.||:...|
Mouse   741 EDIEALIGPPPHGPKKMIAPQKWIDAEKERQASGEEEAPAP 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6512	NP_730248.2	FtsH_ext	163..259	CDD:284011	31/108 (29%)
		FtsH_fam	271..764	CDD:273520	248/499 (50%)
		AAA	365..496	CDD:278434	80/131 (61%)
		Peptidase_M41	580..762	CDD:279742	85/183 (46%)
Spg7	NP_694816.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..56		6/22 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	103..135		6/52 (12%)
		FtsH_ext	145..242	CDD:284011	31/105 (30%)
		FtsH_fam	265..748	CDD:273520	245/489 (50%)
		AAA	346..479	CDD:278434	80/132 (61%)
		Peptidase_M41	561..746	CDD:279742	85/184 (46%)
		Interaction with PPIF. /evidence=ECO:0000250\|UniProtKB:Q9UQ90	701..781		20/79 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119497at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820