DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6512 and spg-7

DIOPT Version :9

Sequence 1:	NP_730248.2	Gene:	CG6512 / 39922	FlyBaseID:	FBgn0036702	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_491165.2	Gene:	spg-7 / 171915	WormBaseID:	WBGene00004978	Length:	782	Species:	Caenorhabditis elegans

Alignment Length:	784	Identity:	463/784 - (59%)
Similarity:	556/784 - (70%)	Gaps:	59/784 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LCKKPPKGFEKYFEAGGKSSGQPKGSVGDKKPPAGSSKSASEKPS-------------------- 106
            |.:|.||......|:..||....:.||......|...||..::..
Worm     4 LYRKTPKQLRNSVESCFKSVNSRQFSVSSFSAVAKDDKSVLKQQEVLHLLAKDQRFEERFFNQVQ 68

  Fly   107 ------TSTPASVKP---SRSQTDAKSDWNFGMFSNSSRGPAGKGGNSLGGRPLGENGGGGDRER 162
                  .|.|..:|.   ..:.||.|..      |:||.....||.......|..:..||
Worm    69 QTIRYFASKPNDLKKFFRKEASTDNKES------SSSSDKKDSKGNKGEDNNPFNQFPGG----- 122

  Fly   163 WILLGAIGAVVLVGSFAFFE-MGYKEISWKEFVNSYLSKGVVEKLEVVNKKWVRVRLQQNSNSGS 226
            |..: |:...:|:..:||.: ..|:|||||||.:.:|..|:||:||||:|:|||:.......:|.
Worm   123 WQQI-AVSVGILLALYAFMDYQSYREISWKEFYSDFLEAGLVERLEVVDKRWVRIVSSSGKYAGQ 186

  Fly   227 GVLWFNIGSVDSFERNLEAAQTEQGTESINFVPVIYRNEVEAASLTGLLPTL------LIIGFLV 285
             ..:|||||||||||:|.|||.....::...:||:|::|.   :....:|.|      |:.|:.:
Worm   187 -TCYFNIGSVDSFERSLGAAQHHLQYDADRQIPVLYKSEF---NFKREIPNLISVAFPLLFGYYI 247

  Fly   286 YMMRKSADMMGGGRGRKG----GGLFGGVMQSTAKLTNPNEIGVGFKDVAGCEEAKIEIMEFVNF 346
            |.|.|... ..||.||.|    ||:|||..||||::.|..:|.|.|.||||||||||||||||||
Worm   248 YRMLKGGG-AAGGAGRAGGGGLGGMFGGFGQSTARVINREDIKVKFADVAGCEEAKIEIMEFVNF 311

  Fly   347 LKNPQQYIDLGAKIPKGAMLTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPSRVRD 411
            |||||||.||||||||||:|||||||||||||||||||||||||||||||||||||||||:||||
Worm   312 LKNPQQYKDLGAKIPKGAILTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPARVRD 376

  Fly   412 MFAMARKHAPCILFIDEIDAVGRKRGGK-TFGGHSEQENTLNQLLVEMDGFNT-TTNVVVLAATN 474
            ||:||||::||||||||||||||||||| ..||||||||||||||||||||.| .::|:|:||||
Worm   377 MFSMARKNSPCILFIDEIDAVGRKRGGKGGMGGHSEQENTLNQLLVEMDGFTTDESSVIVIAATN 441

  Fly   475 RVDILDKALMRPGRFDRQIYVPAPDIKGRASIFKVHLGNLKTSLDKNELSRKMAALTPGFTGADI 539
            ||||||.||:||||||||||||.||||||||||:||||.|:|||||..||||:||.||||:||||
Worm   442 RVDILDSALLRPGRFDRQIYVPVPDIKGRASIFRVHLGPLRTSLDKTVLSRKLAAHTPGFSGADI 506

  Fly   540 ANVCNEAALIAARDSKDSIVLKHFEQAIERVIAGMEKKTNVLAPEEKRTVAHHEAGHAVAGWFLE 604
            :|||||||||||||:...|..||||||||||:|||||||.||..|||:|||:||||||:|||||:
Worm   507 SNVCNEAALIAARDANHEISNKHFEQAIERVVAGMEKKTQVLQKEEKKTVAYHEAGHAIAGWFLQ 571

  Fly   605 HADPLLKVSIIPRGKGLGYAQYLPKDHYLLSKEQLFDRMCMTLGGRVAEELFFNRITTGAQDDLK 669
            |||||||||||||||||||||||||:.||.||:||.||||||||||||||:||.||||||||||:
Worm   572 HADPLLKVSIIPRGKGLGYAQYLPKEQYLYSKDQLLDRMCMTLGGRVAEEIFFGRITTGAQDDLQ 636

  Fly   670 KITDIAYSQVVRFGMNEKVGQVSFDVGQAGDPVFSKPYSEDTAQLIDNEVRSIIKCAHEATTSLL 734
            |:|.:||||||:|||:||||.:||:....|:..|.|||||.||||||.|||.::..|...|..||
Worm   637 KVTQMAYSQVVKFGMSEKVGPLSFETPAPGEMAFDKPYSEATAQLIDQEVRDLVMNALRRTRDLL 701

  Fly   735 TKHKENVQKVAERLLQNEVLSRDDMIELLGPRPFKEKSTYEEFVEGTGSFEEDTTLPEGLKSWNK 799
            .:.:.::::||.|||:.|:|:|:|||||:|.|||.||:||||.|.|||..:|:..||:||::|||
Worm   702 LEKRSDIERVALRLLEKEILNREDMIELVGKRPFVEKNTYEEMVSGTGGLDENVELPKGLENWNK 766

  Fly   800 EKER 803
            |.|:
Worm   767 ESEK 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6512	NP_730248.2	FtsH_ext	163..259	CDD:284011	41/96 (43%)
		FtsH_fam	271..764	CDD:273520	368/504 (73%)
		AAA	365..496	CDD:278434	115/132 (87%)
		Peptidase_M41	580..762	CDD:279742	124/181 (69%)
spg-7	NP_491165.2	FtsH_ext	123..218	CDD:310823	41/96 (43%)
spg-7	NP_491165.2	TIP49	278..731	CDD:332389	350/452 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	260	1.000	Domainoid score	I1059
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4947
Inparanoid	1	1.050	850	1.000	Inparanoid score	I225
Isobase	1	0.950	-	0	Normalized mean entropy	S505
OMA	1	1.010	-	-		QHG57866
OrthoDB	1	1.010	-	-		D119497at33208
OrthoFinder	1	1.000	-	-		FOG0001522
OrthoInspector	1	1.000	-	-		oto18650
orthoMCL	1	0.900	-	-		OOG6_100384
Panther	1	1.100	-	-	LDO	PTHR43655
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2012
SonicParanoid	1	1.000	-	-		X961
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.820