DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6512 and AFG3L2

DIOPT Version :9

Sequence 1:	NP_730248.2	Gene:	CG6512 / 39922	FlyBaseID:	FBgn0036702	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_006787.2	Gene:	AFG3L2 / 10939	HGNCID:	315	Length:	797	Species:	Homo sapiens

Alignment Length:	785	Identity:	493/785 - (62%)
Similarity:	583/785 - (74%)	Gaps:	77/785 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LLRYVVKQIQLLCKKPPKGFEKYFEAG--GKSSGQPKGSVGDKKPPAGSSKSASEKPSTSTPASV 113
            ||..::...|..|.:|||||||||..|  ||.:.:||..:|:||         ..||:.:|.:|
Human    54 LLTDIIAAYQRFCSRPPKGFEKYFPNGKNGKKASEPKEVMGEKK---------ESKPAATTRSS- 108

  Fly   114 KPSRSQTDAKSDWNFGMFSNSSRGPAGKGGNSLGGRPLGENGGGGDRERW--------------- 163
                                        ||...||   |:.||..|...|
Human   109 ----------------------------GGGGGGG---GKRGGKKDDSHWWSRFQKGDIPWDDKD 142

  Fly   164 ----ILLGAI--GAVVLVGSFAFFEMGYKEISWKEFVNSYLSKGVVEKLEVVNKKWVRVRLQQNS 222
                .|..|:  |.|:.   :...:...:||:||:|||:|||||||::||||||::|||......
Human   143 FRMFFLWTALFWGGVMF---YLLLKRSGREITWKDFVNNYLSKGVVDRLEVVNKRFVRVTFTPGK 204

  Fly   223 NSGSG-VLWFNIGSVDSFERNLEAAQTEQGTESINFVPVIYRNEVEAASLTGLLPTLLIIGFLVY 286
            ....| .:||||||||:||||||..|.|.|.|..|.|||:|..|.:.:.|..:|||:|||.||:|
Human   205 TPVDGQYVWFNIGSVDTFERNLETLQQELGIEGENRVPVVYIAESDGSFLLSMLPTVLIIAFLLY 269

  Fly   287 MMRKSADMMGGGR-GRKGGGLFGGVMQSTAKLTNPNEIGVGFKDVAGCEEAKIEIMEFVNFLKNP 350
            .:|:..  .|.|| ||..|||| .|.::|||:.. :||.|.|||||||||||:||||||||||||
Human   270 TIRRGP--AGIGRTGRGMGGLF-SVGETTAKVLK-DEIDVKFKDVAGCEEAKLEIMEFVNFLKNP 330

  Fly   351 QQYIDLGAKIPKGAMLTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPSRVRDMFAM 415
            :||.||||||||||:|||||||||||||||||||||||||||||||||||||||||:||||:||:
Human   331 KQYQDLGAKIPKGAILTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPARVRDLFAL 395

  Fly   416 ARKHAPCILFIDEIDAVGRKRGGKTFGGHSEQENTLNQLLVEMDGFNTTTNVVVLAATNRVDILD 480
            |||:||||||||||||||||||...|||.||||||||||||||||||||||||:||.|||.||||
Human   396 ARKNAPCILFIDEIDAVGRKRGRGNFGGQSEQENTLNQLLVEMDGFNTTTNVVILAGTNRPDILD 460

  Fly   481 KALMRPGRFDRQIYVPAPDIKGRASIFKVHLGNLK--TSLDKNELSRKMAALTPGFTGADIANVC 543
            .||:|||||||||::..||||||||||||||..||  ::|:|::|:||:|:|||||:|||:||||
Human   461 PALLRPGRFDRQIFIGPPDIKGRASIFKVHLRPLKLDSTLEKDKLARKLASLTPGFSGADVANVC 525

  Fly   544 NEAALIAARDSKDSIVLKHFEQAIERVIAGMEKKTNVLAPEEKRTVAHHEAGHAVAGWFLEHADP 608
            |||||||||...|||..|||||||||||.|:||||.||.||||:|||:||||||||||:||||||
Human   526 NEAALIAARHLSDSINQKHFEQAIERVIGGLEKKTQVLQPEEKKTVAYHEAGHAVAGWYLEHADP 590

  Fly   609 LLKVSIIPRGKGLGYAQYLPKDHYLLSKEQLFDRMCMTLGGRVAEELFFNRITTGAQDDLKKITD 673
            |||||||||||||||||||||:.||.:||||.|||||||||||:||:||.||||||||||:|:|.
Human   591 LLKVSIIPRGKGLGYAQYLPKEQYLYTKEQLLDRMCMTLGGRVSEEIFFGRITTGAQDDLRKVTQ 655

  Fly   674 IAYSQVVRFGMNEKVGQVSFDVGQAGDPVFSKPYSEDTAQLIDNEVRSIIKCAHEATTSLLTKHK 738
            .||:|:|:|||||||||:|||:.:.||.|..|||||.||:|||:|||.:|..|::.|.:|||:.|
Human   656 SAYAQIVQFGMNEKVGQISFDLPRQGDMVLEKPYSEATARLIDDEVRILINDAYKRTVALLTEKK 720

  Fly   739 ENVQKVAERLLQNEVLSRDDMIELLGPRPFKEKSTYEEFVEGTGSFEEDTTLPEGLKSWNK--EK 801
            .:|:|||..||:.|||.::||:||||||||.||||||||||||||.:|||:||||||.|||  ||
Human   721 ADVEKVALLLLEKEVLDKNDMVELLGPRPFAEKSTYEEFVEGTGSLDEDTSLPEGLKDWNKEREK 785

  Fly   802 ERTEP 806
            |:.||
Human   786 EKEEP 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6512	NP_730248.2	FtsH_ext	163..259	CDD:284011	48/117 (41%)
		FtsH_fam	271..764	CDD:273520	370/495 (75%)
		AAA	365..496	CDD:278434	115/130 (88%)
		Peptidase_M41	580..762	CDD:279742	129/181 (71%)
AFG3L2	NP_006787.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..126		22/90 (24%)
		FtsH_ext	146..242	CDD:310823	47/98 (48%)
		TIP49	253..746	CDD:332389	370/496 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	759..797		24/32 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	270	1.000	Domainoid score	I1844
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4947
Inparanoid	1	1.050	909	1.000	Inparanoid score	I369
Isobase	1	0.950	-	0	Normalized mean entropy	S505
OMA	1	1.010	-	-		QHG57866
OrthoDB	1	1.010	-	-		D119497at33208
OrthoFinder	1	1.000	-	-		FOG0001522
OrthoInspector	1	1.000	-	-		oto88323
orthoMCL	1	0.900	-	-		OOG6_100384
Panther	1	1.100	-	-	O	PTHR43655
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2012
SonicParanoid	1	1.000	-	-		X961
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820