Protein Alignment Afg3l2 and spg7

DIOPT Version :10

• Sequence 1: NP_730248.2
• Gene: Afg3l2 / 39922
• FlyBaseID: FBgn0036702
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: XP_002933705.2
• Gene: spg7 / 100485977
• XenbaseID: XB-GENE-6034036
• Length: 768
• Species: Xenopus tropicalis
• Alignment Length: 849
• Identity: 313/849 - (36%)
• Similarity: 462/849 - (54%)
• Gaps: 146/849 - (17%)

  Fly     9 AKTMAGMMRRNYTAGSLPGKGQRTHMGATGAGVYILPTELSPLLRYVVKQIQLLCKKPPK----- 68
            ::.:..::.||.|.||   .|.|                     .|::|  :.|.:.|.:
 Frog    30 SRILQNLLCRNLTPGS---HGMR---------------------EYLIK--RHLIQDPLRIWRIL 68

  Fly    69 GFEKYFEAGGKSSGQPKGSVGDKKPPAGSSKSASEKPSTSTPASVKPSRSQTDAKSDWNFGMFSN 133
            |...||...|:                |:.::.:|.....||...:..:.:.:.:..    |:
 Frog    69 GGINYFSTSGR----------------GNKENQNEGSKGKTPHEDEEEKKRREREDQ----MY-- 111

  Fly   134 SSRGPAGKGGNSLGGRPLGENGGGGDRERWILLGAIGAVV-LVGSFAFFEMGYKEISWKEFVNSY 197
                                      |||...|..|..:: |:.|.:   .....|||.:|||..
 Frog   112 --------------------------RERLRTLFIIAVIMSLLNSLS---SSGGNISWNDFVNEM 147

  Fly   198 LSKGVVEKLEVVNKKWV-------------RVRLQQNSNSGSGVLW-FNIGSVDSFERNLEAAQT 248
            |:||.|.:::||.:..:             |.||        .::: ..:.::|.||..|.||:.
 Frog   148 LAKGEVMRVQVVPESDIVEIYLYPGAVVFGRPRL--------ALMYRMQVANIDKFEEKLRAAEE 204

  Fly   249 EQGTESINFVPVIYRNEVEAASLTGLLPTLLI--------IGFLVYMMRKSADMMGGGRGRKGGG 305
            |......:.:||.|:.       ||.....|.        :..|.|:.|     :.|..||:|.
 Frog   205 ELKINVKDRIPVSYKR-------TGFFGNALYALGMAAVGVAILWYIFR-----LAGMAGREGA- 256

  Fly   306 LFGGVMQ-STAKLT---NPNEIGVGFKDVAGCEEAKIEIMEFVNFLKNPQQYIDLGAKIPKGAML 366
             |....| ..|:.|   ..:..|:.||||||..|||:|:.|||::||:|.:|:.||||:||||:|
 Frog   257 -FSAFNQLKMARFTIVDGKSGKGISFKDVAGMHEAKLEVKEFVDYLKSPDRYLQLGAKVPKGALL 320

  Fly   367 TGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPSRVRDMFAMARKHAPCILFIDEIDA 431
            .||||.||||||||.|.||.|||:.::||||:|:..|:|.:|||.:|..||..||||::||||||
 Frog   321 LGPPGCGKTLLAKAVATEAQVPFLAMAGSEFVEVIGGLGAARVRSLFKEARTRAPCIVYIDEIDA 385

  Fly   432 VGRKRG-GKTFGGHSEQENTLNQLLVEMDGFNTTTNVVVLAATNRVDILDKALMRPGRFDRQIYV 495
            ||:||. ..:...::|:|.|||||||||||..||.:|:|||:|||.||||.|||||||.||.|::
 Frog   386 VGKKRSTNMSSFSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDNALMRPGRLDRHIFI 450

  Fly   496 PAPDIKGRASIFKVHLGNLKTSLDKNELSRKMAALTPGFTGADIANVCNEAALIAARDSKDSIVL 560
            ..|.::.|..||:.||.:||.:...:..|:::|.|||||:||||||:||||||.|||:...||..
 Frog   451 DLPTLQERREIFEQHLKSLKLTQPGSFYSQRLAELTPGFSGADIANICNEAALHAAREGYQSIDT 515

  Fly   561 KHFEQAIERVIAGMEKKTNVLAPEEKRTVAHHEAGHAVAGWFLEHADPLLKVSIIPR-GKGLGYA 624
            .:||.|:||||||..||:.:::.||:|.||.||:|||:.||.|||.:.::||||.|| ...||:|
 Frog   516 FNFEYAVERVIAGTAKKSKIMSKEERRVVAFHESGHALVGWLLEHTEAVMKVSIAPRTNAALGFA 580

  Fly   625 QYLPKDHYLLSKEQLFDRMCMTLGGRVAEELFFNRITTGAQDDLKKITDIAYSQVVRFGMNEKVG 689
            |.||::.||.:||||.:||||.|||||:|.:.||::||||||||:|:|.|||:.|.::||...:|
 Frog   581 QILPREQYLYTKEQLLERMCMALGGRVSEAITFNKVTTGAQDDLRKVTRIAYAMVKQYGMVPSIG 645

  Fly   690 QVSFDVGQAGDPVFSKPYSEDTAQLIDNEVRSIIKCAHEATTSLLTKHKENVQKVAERLLQNEVL 754
            ||||...::...:..:|:|:...:::|.|.:.::..|:..|..||..:::.:..:...||:.||:
 Frog   646 QVSFPDSESTPGIGRRPFSQGLQEMMDREAQLLVSTAYRRTEKLLLDNRDKLILLTNALLEREVI 710

  Fly   755 SRDDMIELLGPRPF--KEKSTYEEFVEGTGSFEEDTTLPEGLKSWNKEKERTEPLDAGSTPSSPP 817
            :.||:..|:||.||  |:..:.:.::|.    |:|       |..:.|:|..:|.........|.
 Frog   711 NYDDIEHLIGPPPFGAKKMISPQSWIEA----EKD-------KQDSGEEEPRQPPPRREDEEEPN 764

  Fly   818 TKPV 821
            ..||
 Frog   765 LNPV 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Afg3l2	NP_730248.2	HflB	168..765	CDD:440233	274/625 (44%)
spg7	XP_002933705.2	HflB	118..721	CDD:440233	275/627 (44%)