DRSC/TRiP Functional Genomics Resources

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Protein Alignment Rbp6 and TIA1

DIOPT Version :10

Sequence 1:NP_001097631.1 Gene:Rbp6 / 39919 FlyBaseID:FBgn0260943 Length:499 Species:Drosophila melanogaster
Sequence 2:NP_071505.2 Gene:TIA1 / 7072 HGNCID:11802 Length:386 Species:Homo sapiens


Alignment Length:256 Identity:61/256 - (23%)
Similarity:109/256 - (42%) Gaps:36/256 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 MFIGGLSWQTSPESLRDYFGRYGDISEAMVMKDPTTRRSRGFGFVTFSDPNSVDKVLTQ-GTHEL 94
            :|:|.||.:.:.|.::..|..:|.||:|.|:||..|.:|:|:|||:|.:....:..:.| |...|
Human   108 VFVGDLSPEITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWL 172

  Fly    95 DGKKVDPKVAFPRRAHPKMV--TRTKK----------------IFVGGLSAPTTLEDVKSYFEQF 141
            .|:::....|..:...||..  :.||:                ::.||:::..|.:.::..|..|
Human   173 GGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMRQTFSPF 237

  Fly   142 GPIEDAMLMFDKQTNRHRGFGFVTFQS-EDVVDKVCEIHFHEINNKMVECKKAQPKEVMLPANLA 205
            |.|.:..:..||      |:.||.|.| |.....:..::...|...:|:|...:....|:.....
Human   238 GQIMEIRVFPDK------GYSFVRFNSHESAAHAIVSVNGTTIEGHVVKCYWGKETLDMINPVQQ 296

  Fly   206 KTRAAGRSAYGELVVWGSSHAHSTAATSAAAAG-LLPSSLAAAASVLQQQQQQQQQQQQQQ 265
            :.:......||:   ||..:.      :|...| .:|:.....|..:..|...||...|.|
Human   297 QNQIGYPQPYGQ---WGQWYG------NAQQIGQYMPNGWQVPAYGMYGQAWNQQGFNQTQ 348

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Rbp6NP_001097631.1 RRM1_MSI 30..105 CDD:409990 24/74 (32%)
RRM2_MSI 119..192 CDD:240769 18/89 (20%)
TIA1NP_071505.2 RRM1_TIA1 8..81 CDD:410027
RRM2_TIA1 104..181 CDD:410030 24/72 (33%)
RRM3_TIAR 214..286 CDD:241064 18/77 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 354..386
Blue background indicates that the domain is not in the aligned region.

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