DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rbp6 and msi2b

DIOPT Version :9

Sequence 1:	NP_001097631.1	Gene:	Rbp6 / 39919	FlyBaseID:	FBgn0260943	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_957403.1	Gene:	msi2b / 394084	ZFINID:	ZDB-GENE-040426-1268	Length:	408	Species:	Danio rerio

Alignment Length:	436	Identity:	194/436 - (44%)
Similarity:	238/436 - (54%)	Gaps:	63/436 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SPSEVPNDPGKMFIGGLSWQTSPESLRDYFGRYGDISEAMVMKDPTTRRSRGFGFVTFSDPNSVD 84
            ||::..:||||||||||||||||:||||||.::|:|.|.|||:||||:||||||||||:|..|||
Zfish    12 SPNDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADAASVD 76

  Fly    85 KVLTQGTHELDGKKVDPKVAFPRRAHPKMVTRTKKIFVGGLSAPTTLEDVKSYFEQFGPIEDAML 149
            |||.|..||||.|.:||||||||||.|||||||||||||||||.|.:||||.||||||.:|||||
Zfish    77 KVLAQPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAML 141

  Fly   150 MFDKQTNRHRGFGFVTFQSEDVVDKVCEIHFHEINNKMVECKKAQPKEVMLPANLAKTRAAGRSA 214
            ||||.||||||||||||::||||:||||||||||||||||||||||||||.|.. .:.||.|...
Zfish   142 MFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPG-TRGRARGLPY 205

  Fly   215 YGELVVWGS---SHAHSTAATSAAAAGLLPS--------------SLAAAASVLQQQQQQQQQQQ 262
            ..:..:.|.   |:.:..|.......|..||              .:||||:|...:...:..:.
Zfish   206 TMDAFMLGMGMLSYPNIVATYGRGYTGFAPSYSYQFPGFPATAYGPVAAAAAVAAARGSGRGARG 270

  Fly   263 QQQQQQQQHHQQLHHTHPQSPAHSHAHHPHTHSHSQLLG-SLRYTPYPLPAHLSAAAVVVAQQQH 326
            :..          :..:|||.......:....|.|...| ...:..|   ..|...|..:.|.:|
Zfish   271 RGG----------YAAYPQSTGPGFPDYGFYSSPSDQRGPPFSFADY---GSLGPQAAQLLQSEH 322

  Fly   327 HHQQQQQQQQQQQQQQVVAAQQQHQQQQSLAQVVAAAAGAAPGLLPLANPAPPATPSLLQFAAGQ 391
            .........|.      :|:..|::               :||..|   |.|.|.|       |.
Zfish   323 ATSACNSPLQH------LASPDQYK---------------SPGTNP---PRPGAFP-------GA 356

  Fly   392 SNAALANSLYADAAAVVGYKRLLAAAAVSSGLRAPTTALGALQAAA 437
            |:......||...:...|....::||:...|.....:..|.|.|.|
Zfish   357 SSPGPVADLYGPTSQDSGVGNYISAASPQPGSGFGHSIAGPLIATA 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbp6	NP_001097631.1	RRM1_MSI	31..105	CDD:241020	55/73 (75%)
Rbp6	NP_001097631.1	RRM2_MSI	119..192	CDD:240769	62/72 (86%)
msi2b	NP_957403.1	RRM	<2..162	CDD:223796	116/149 (78%)
		RRM1_MSI	23..97	CDD:241020	55/73 (75%)
		RRM2_MSI	111..184	CDD:240769	62/72 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579359
Domainoid	1	1.000	124	1.000	Domainoid score	I5451
eggNOG	1	0.900	-	-		E1_KOG4205
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H62199
Inparanoid	1	1.050	349	1.000	Inparanoid score	I2258
OMA	1	1.010	-	-		QHG47546
OrthoDB	1	1.010	-	-		D1565323at2759
OrthoFinder	1	1.000	-	-		FOG0000417
OrthoInspector	1	1.000	-	-		otm24773
orthoMCL	1	0.900	-	-		OOG6_101082
Panther	1	1.100	-	-	LDO	PTHR48032
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1869
SonicParanoid	1	1.000	-	-		X310
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800