DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rbp6 and HNRNPA3

DIOPT Version :9

Sequence 1:	NP_001097631.1	Gene:	Rbp6 / 39919	FlyBaseID:	FBgn0260943	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_001317178.1	Gene:	HNRNPA3 / 220988	HGNCID:	24941	Length:	378	Species:	Homo sapiens

Alignment Length:	193	Identity:	82/193 - (42%)
Similarity:	117/193 - (60%)	Gaps:	3/193 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PSEVPNDPGKMFIGGLSWQTSPESLRDYFGRYGDISEAMVMKDPTTRRSRGFGFVTFSDPNSVDK 85
            |.| |....|:||||||::|:.:|||::|.::|.:::.:||:||.|:|||||||||:|....||.
Human    28 PKE-PEQLRKLFIGGLSFETTDDSLREHFEKWGTLTDCVVMRDPQTKRSRGFGFVTYSCVEEVDA 91

  Fly    86 VLTQGTHELDGKKVDPKVAFPRR--AHPKMVTRTKKIFVGGLSAPTTLEDVKSYFEQFGPIEDAM 148
            .:....|::||:.|:||.|..|.  ..|......|||||||:...|...:::.|||::|.||...
Human    92 AMCARPHKVDGRVVEPKRAVSREDSVKPGAHLTVKKIFVGGIKEDTEEYNLRDYFEKYGKIETIE 156

  Fly   149 LMFDKQTNRHRGFGFVTFQSEDVVDKVCEIHFHEINNKMVECKKAQPKEVMLPANLAKTRAAG 211
            :|.|:|:.:.|||.||||...|.|||:....:|.||....|.|||..|:.|..|...:.|..|
Human   157 VMEDRQSGKKRGFAFVTFDDHDTVDKIVVQKYHTINGHNCEVKKALSKQEMQSAGSQRGRGGG 219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbp6	NP_001097631.1	RRM1_MSI	31..105	CDD:241020	35/73 (48%)
Rbp6	NP_001097631.1	RRM2_MSI	119..192	CDD:240769	31/72 (43%)
HNRNPA3	NP_001317178.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		3/7 (43%)
		RRM1_hnRNPA_like	36..113	CDD:409992	37/76 (49%)
		RRM2_hnRNPA3	126..205	CDD:409996	35/78 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..225		5/16 (31%)
		HnRNPA1	331..>347	CDD:402981
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	336..378
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1869
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940