DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rbp6 and MSI2

DIOPT Version :9

Sequence 1:	NP_001097631.1	Gene:	Rbp6 / 39919	FlyBaseID:	FBgn0260943	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	XP_005257071.1	Gene:	MSI2 / 124540	HGNCID:	18585	Length:	346	Species:	Homo sapiens

Alignment Length:	297	Identity:	170/297 - (57%)
Similarity:	195/297 - (65%)	Gaps:	45/297 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SPSEVPNDPGKMFIGGLSWQTSPESLRDYFGRYGDISEAMVMKDPTTRRSRGFGFVTFSDPNSVD 84
            |.::..:||||||||||||||||:||||||.::|:|.|.|||:||||:||||||||||:||.|||
Human    12 SANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVD 76

  Fly    85 KVLTQGTHELDGKKVDPKVAFPRRAHPKMVTRTKKIFVGGLSAPTTLEDVKSYFEQFGPIEDAML 149
            |||.|..||||.|.:||||||||||.|||||||||||||||||.|.:||||.||||||.:|||||
Human    77 KVLGQPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAML 141

  Fly   150 MFDKQTNRHRGFGFVTFQSEDVVDKVCEIHFHEINNKMVECKKAQPKEVMLPANLAKTRAAGRS- 213
            ||||.||||||||||||::||||:||||||||||||||||||||||||||.|..   ||...|.
Human   142 MFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPG---TRGRARGL 203

  Fly   214 --------------AYGELVV--------WGSSHAHSTAATSAAAAGLLPSSLAAAA--SVLQQQ 254
                          .|...|.        :..|:.:......|||.|.:.::..|||  |||
Human   204 PYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSVL--- 265

  Fly   255 QQQQQQQQQQQQQQQQHHQQLHHTHPQSPAHSHAHHP 291
                          ..:..|.:...|.|||.|:...|
Human   266 --------------NSYSAQPNFGAPASPAGSNPARP 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbp6	NP_001097631.1	RRM1_MSI	31..105	CDD:241020	56/73 (77%)
Rbp6	NP_001097631.1	RRM2_MSI	119..192	CDD:240769	62/72 (86%)
MSI2	XP_005257071.1	RRM1_MSI2	17..109	CDD:410153	71/91 (78%)
		PABP-1234	<35..343	CDD:130689	153/274 (56%)
		RRM2_MSI	111..184	CDD:240769	62/72 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145875
Domainoid	1	1.000	124	1.000	Domainoid score	I5529
eggNOG	1	0.900	-	-		E1_KOG4205
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H62199
Inparanoid	1	1.050	359	1.000	Inparanoid score	I2219
Isobase	1	0.950	-	0	Normalized mean entropy	S972
OMA	1	1.010	-	-		QHG47546
OrthoDB	1	1.010	-	-		D1565323at2759
OrthoFinder	1	1.000	-	-		FOG0000417
OrthoInspector	1	1.000	-	-		otm42259
orthoMCL	1	0.900	-	-		OOG6_101082
Panther	1	1.100	-	-	LDO	PTHR48032
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1869
SonicParanoid	1	1.000	-	-		X310
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750