DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rbp6 and msi2

DIOPT Version :9

Sequence 1:	NP_001097631.1	Gene:	Rbp6 / 39919	FlyBaseID:	FBgn0260943	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	XP_004911774.1	Gene:	msi2 / 100038158	XenbaseID:	XB-GENE-488852	Length:	407	Species:	Xenopus tropicalis

Alignment Length:	451	Identity:	198/451 - (43%)
Similarity:	233/451 - (51%)	Gaps:	104/451 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SPSEVPNDPGKMFIGGLSWQTSPESLRDYFGRYGDISEAMVMKDPTTRRSRGFGFVTFSDPNSVD 84
            ||::..:||||||||||||||||:||||||.::|:|.|.|||:||||:||||||||||:||.|||
Frog    12 SPNDSQHDPGKMFIGGLSWQTSPDSLRDYFNKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVD 76

  Fly    85 KVLTQGTHELDGKKVDPKVAFPRRAHPKMVTRTKKIFVGGLSAPTTLEDVKSYFEQFGPIEDAML 149
            |||.|..||||.|.:||||||||||.|||||||||||||||||.|.:||||.||||||.:|||||
Frog    77 KVLAQPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAML 141

  Fly   150 MFDKQTNRHRGFGFVTFQSEDVVDKVCEIHFHEINNKMVECKKAQPKEVMLPANLAKTRAAGRS- 213
            ||||.||||||||||||:.||||:||||||||||||||||||||||||||.|..   ||...|.
Frog   142 MFDKTTNRHRGFGFVTFEIEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPG---TRGRARGL 203

  Fly   214 --------------AYGELVV--------WGSSHAHSTAATSAAAA-GLLPSSLAAAAS------ 249
                          .|...|.        :..|:::......|||| |.:.::..|||.
Frog   204 PYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYSYQFPGFPAAAAYGPVAAAAVAAARGSGIPD 268

  Fly   250 ----VLQQQQQQQQQQQQQQQQQQQHHQQLHHTHPQSPAHSHAHHPHTHSHSQLLGSLRYTPYPL 310
                .....|:.............:..|.|...|..|.::|..||                 .|.
Frog   269 YGFYTTPGDQRATLSFADYGSMGPRTAQMLRSEHAASASNSPLHH-----------------LPS 316

  Fly   311 PAHLSAAAVVVAQQQHHHQQQQQQQQQQQQQQVVAAQQQHQQQQSLAQVVAAAAGAAPGLLPLAN 375
            |....:.||:                     ...:||..:....|    .|.|..|.||..|.||
Frog   317 PDQFKSPAVL---------------------NSYSAQPNYGAPAS----PAGANPARPGGFPGAN 356

  Fly   376 -PAPPATPSLLQFAAGQSNAALANSLYADAAAVVGYKRLLAAAA------VSSGLRAPTTA 429
             |.|.|                  .||..|:...|....::||:      .|.|:..|..|
Frog   357 SPGPVA------------------DLYGTASQDSGVGNYISAASPQPGSGFSHGIAGPLIA 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbp6	NP_001097631.1	RRM1_MSI	31..105	CDD:241020	56/73 (77%)
Rbp6	NP_001097631.1	RRM2_MSI	119..192	CDD:240769	62/72 (86%)
msi2	XP_004911774.1	RRM	<2..162	CDD:223796	117/149 (79%)
		RRM1_MSI	23..97	CDD:241020	56/73 (77%)
		RRM2_MSI	111..184	CDD:240769	62/72 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5508
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H62199
Inparanoid	1	1.050	357	1.000	Inparanoid score	I2175
OMA	1	1.010	-	-		QHG47546
OrthoDB	1	1.010	-	-		D1565323at2759
OrthoFinder	1	1.000	-	-		FOG0000417
OrthoInspector	1	1.000	-	-		otm49489
Panther	1	1.100	-	-	LDO	PTHR48032
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X310
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080