Protein Alignment CG7724 and HSD3B1

DIOPT Version :10

• Sequence 1: NP_648957.1
• Gene: CG7724 / 39918
• FlyBaseID: FBgn0036698
• Length: 398
• Species: Drosophila melanogaster
• Sequence 2: NP_000853.1
• Gene: HSD3B1 / 3283
• HGNCID: 5217
• Length: 373
• Species: Homo sapiens
• Alignment Length: 410
• Identity: 116/410 - (28%)
• Similarity: 188/410 - (45%)
• Gaps: 59/410 - (14%)

  Fly     5 SGEVLLVTGGSGFLGQHLIKQLLERKEELGIKEIRSLDIVPYKNNIG---HEETSLL--RTYVAD 64
            :|...||||..|||||.:|:.|::.||   :||||.||     ...|   .||.|.|  :|.:..
Human     2 TGWSCLVTGAGGFLGQRIIRLLVKEKE---LKEIRVLD-----KAFGPELREEFSKLQNKTKLTV 58

  Fly    65 IGGDL---KALSPIFNGVDGVFHCAASVKIEYPPNYEELERVNVNGTLAVVDLCIQNNVKRLVYT 126
            :.||:   ..|......|..:.|.|..:.:....:.|.:..|||.||..:::.|:|.:|...:||
Human    59 LEGDILDEPFLKRACQDVSVIIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPVFIYT 123

  Fly   127 SCTSVCFVPFKGRSTFSAVINSTESKTDTPTLDSSTLWEQDNQFLIPGYASSKLRAENIVLNSNG 191
            |...|.     |.:::..:|.:...:...           :|.:..| |..||..||..||.:||
Human   124 SSIEVA-----GPNSYKEIIQNGHEEEPL-----------ENTWPAP-YPHSKKLAEKAVLAANG 171

  Fly   192 APLHNQKEYLATSAMRAPLTYGECDSHFITEIFDFLSTRGWVFPRIAGVGGKQQL--VYAGNVAW 254
            ..|.|... |.|.|:|....|||........|.:.|:..|    .::.||....:  ||.|||||
Human   172 WNLKNGGT-LYTCALRPMYIYGEGSRFLSASINEALNNNG----ILSSVGKFSTVNPVYVGNVAW 231

  Fly   255 GHICAYKALKVSDKA--VNGLPVFVTDDT------GINDVSRFVQKMAVLGERFKVK-TSWWYVP 310
            .||.|.:||:...||  :.|...:::|||      .:|         ..|.:.|.:: .|.|..|
Human   232 AHILALRALQDPKKAPSIRGQFYYISDDTPHQSYDNLN---------YTLSKEFGLRLDSRWSFP 287

  Fly   311 HFLFFFLAFLLEVVVRVAYPYTKYRLRYSLRAIASYTSSMLMYNRLRASIHMDYMPLFDPDASAE 375
            ..|.:::.||||:|..:..|...||..:: |.|.:.::|:..::..:|...:.|.||:..:.:.:
Human   288 LSLMYWIGFLLEIVSFLLRPIYTYRPPFN-RHIVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQ 351

  Fly   376 RSAKWYATWWDQRQQAQKLK 395
            ::.:|..:..|:.::..|.|
Human   352 KTVEWVGSLVDRHKETLKSK 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7724	NP_648957.1	Rossmann-fold NAD(P)(+)-binding proteins	8..381	CDD:473865	111/391 (28%)
HSD3B1	NP_000853.1	3b-HSD_HSDB1_like_SDR_e	5..357	CDD:187671	111/391 (28%)