DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TpnC73F and CAPS

DIOPT Version :9

Sequence 1:	NP_001287091.1	Gene:	TpnC73F / 39916	FlyBaseID:	FBgn0010424	Length:	155	Species:	Drosophila melanogaster
Sequence 2:	NP_004049.3	Gene:	CAPS / 828	HGNCID:	1487	Length:	189	Species:	Homo sapiens

Alignment Length:	163	Identity:	39/163 - (23%)
Similarity:	68/163 - (41%)	Gaps:	29/163 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LQKAFNSFDHQKTGSIPTEMVADILRLMGQPFDKKILEELIEEVDEDKSGRLEFGEFVQLAAKFI 80
            |.:.|...|...:.|:..:.....|..:|...|:...|.:..:.|.:.||.|:..||:: |.:..
Human    26 LARFFRQLDRDGSRSLDADEFRQGLAKLGLVLDQAEAEGVCRKWDRNGSGTLDLEEFLR-ALRPP 89

  Fly    81 VEEDAEAMQKELREAFRLYDKQGNGFIPTTCLKEIL------KELDDQLTEQE-LDIMIEEIDS- 137
            :.:..||:   :..||...|:.|:|.:....|:.:.      |....:.||.| |...::..||
Human    90 MSQAREAV---IAAAFAKLDRSGDGVVTVDDLRGVYSGRAHPKVRSGEWTEDEVLRRFLDNFDSS 151

  Fly   138 --DGSGTV----DF-----------DEFMEMMT 153
              ||..|:    |:           :||:.|||
Human   152 EKDGQVTLAEFQDYYSGVSASMNTDEEFVAMMT 184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TpnC73F	NP_001287091.1	PTZ00184	6..153	CDD:185504	37/161 (23%)
CAPS	NP_004049.3	EFh_PI-PLC	26..165	CDD:333715	33/142 (23%)
		EFh	26..87	CDD:238008	15/61 (25%)
		EF-hand motif	26..54	CDD:320029	5/27 (19%)
		EF-hand motif	61..89	CDD:320029	8/28 (29%)
		EF-hand motif	94..131	CDD:320029	9/39 (23%)
		EF-hand motif	139..165	CDD:320029	7/25 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148550
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930