DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TpnC73F and EFCAB6

DIOPT Version :9

Sequence 1:	NP_001287091.1	Gene:	TpnC73F / 39916	FlyBaseID:	FBgn0010424	Length:	155	Species:	Drosophila melanogaster
Sequence 2:	XP_011528618.1	Gene:	EFCAB6 / 64800	HGNCID:	24204	Length:	1613	Species:	Homo sapiens

Alignment Length:	149	Identity:	29/149 - (19%)
Similarity:	55/149 - (36%)	Gaps:	29/149 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LQKAFNSFDHQKTGSIPTEMVADILRLMGQPFDKKILEELI------------------------ 56
            :.|||...|..||..|....:.::|...|....:..|..|:
Human   995 ISKAFTKTDQSKTNYISICKMQEVLEECGCSLTEGELTHLLNSWGVSRHDNAINYLDFLRAVENS 1059

  Fly    57 -----EEVDEDKSGRLEFGEFVQLAAKFIVEEDAEAMQKELREAFRLYDKQGNGFIPTTCLKEIL 116
                 :..::::|..:.|.......|...::|..|:.|..|..||...||:..||:..|...::|
Human  1060 KSTGAQPKEKEESMPINFATLNPQEAVRKIQEVVESSQLALSTAFSALDKEDTGFVKATEFGQVL 1124

  Fly   117 KELDDQLTEQELDIMIEEI 135
            |:...:||:.:....:.::
Human  1125 KDFCYKLTDNQYHYFLRKL 1143

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TpnC73F	NP_001287091.1	PTZ00184	6..153	CDD:185504	29/149 (19%)
EFCAB6	XP_011528618.1	EFh	100..152	CDD:298682
		EF-hand_7	203..261	CDD:290234
		EFh	203..261	CDD:298682
		FRQ1	320..495	CDD:227455
		EFh	434..494	CDD:238008
		FRQ1	989..1135	CDD:227455	29/139 (21%)
		EF-hand_11	1186..1286	CDD:286115
		EFh	1211..1264	CDD:298682
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148544
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930