DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Papst2 and Slc35b3

DIOPT Version :9

Sequence 1:	NP_648954.1	Gene:	Papst2 / 39914	FlyBaseID:	FBgn0036695	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	XP_006516590.1	Gene:	Slc35b3 / 108652	MGIID:	1913978	Length:	444	Species:	Mus musculus

Alignment Length:	373	Identity:	208/373 - (55%)
Similarity:	263/373 - (70%)	Gaps:	24/373 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SPPS--QRKSSTSESPPELRILCFDLTYYNRTTQFLLSCAGVFFLYILYGYLQELIFTVEGFKPY 92
            |.||  |..|...:|..::.:|..:|:.:::.||||:..||||..|::|||||||||:|||||||
Mouse    59 SVPSKTQAMSPHIKSVEDVVVLGVNLSKFSKLTQFLICVAGVFVFYLIYGYLQELIFSVEGFKPY 123

  Fly    93 GWFLTLVQFGYYIGFGLVERRLE------------------GYRIS--GGSFWNIEPEPRCIPMR 137
            ||:||||||.:|..|||:|.:|.                  .||.|  .|:.|.|...|| ||.:
Mouse   124 GWYLTLVQFAFYSVFGLIELQLTQDRRRSPVSPSVSFFSVYEYRWSSLSGTPWFITFIPR-IPGK 187

  Fly   138 TYLILAALTLGTMGLSNSSLGYLNYPTQVIFKCCKLIPVLVGSILIQGKRYGLLDFAAATCMCIG 202
            ||:::|.||:|||||||:|||||||||||||||||||||::|.:.||||||.|.|.:||.||.:|
Mouse   188 TYMLIAFLTVGTMGLSNTSLGYLNYPTQVIFKCCKLIPVMLGGVFIQGKRYNLADVSAAVCMSLG 252

  Fly   203 LAWFTLADSQMTPNFNLLGVAMISGALLCDAAIGNVQEKAMREFKAPSSEVVFYSYGLGFVYLFV 267
            |.|||||||.:.|||||.||.:||.||..||.|||||||||:...|.:||:|.|||.:||||:.:
Mouse   253 LIWFTLADSTIAPNFNLTGVMLISLALCADAVIGNVQEKAMKLHNASNSEMVLYSYSIGFVYILL 317

  Fly   268 IMLVTGNFFSGFAFCLEHPVETFGYGFLFSLSGYLGIQFVLALVRSSGAPIAATVTTARKAVTIA 332
            .:..|.......|||.::||.|:||.|||||:||.||.|||||::..||.:|.||||.|||:|:.
Mouse   318 GLSCTSGLGPAVAFCSKNPVGTYGYAFLFSLTGYFGISFVLALIKIFGALLAVTVTTGRKAMTVV 382

  Fly   333 FSFVLFSKPFTLQYLWSGLIVVLGIYLNVYSKR-NKLTLADVRQRIKQ 379
            .||:.|:||||.||:||||:|||||:||||||. :|:.|..|...||:
Mouse   383 LSFLFFAKPFTFQYIWSGLLVVLGIFLNVYSKNMDKIRLPSVYNMIKK 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Papst2	NP_648954.1	UAA	61..364	CDD:285625	192/322 (60%)
Papst2	NP_648954.1	EamA	219..362	CDD:279264	83/142 (58%)
Slc35b3	XP_006516590.1	UAA	92..414	CDD:312076	192/322 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836987
Domainoid	1	1.000	381	1.000	Domainoid score	I841
eggNOG	1	0.900	-	-		E1_COG0697
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9313
Inparanoid	1	1.050	394	1.000	Inparanoid score	I1955
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S1801
OMA	1	1.010	-	-		QHG57264
OrthoDB	1	1.010	-	-		D440867at33208
OrthoFinder	1	1.000	-	-		FOG0005379
OrthoInspector	1	1.000	-	-		oto94533
orthoMCL	1	0.900	-	-		OOG6_104682
Panther	1	1.100	-	-	LDO	PTHR10778
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2781
SonicParanoid	1	1.000	-	-		X3814
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750