DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fit2 and FERMT3

DIOPT Version :9

Sequence 1:	NP_648947.1	Gene:	Fit2 / 39907	FlyBaseID:	FBgn0036688	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_001369291.1	Gene:	FERMT3 / 83706	HGNCID:	23151	Length:	667	Species:	Homo sapiens

Alignment Length:	729	Identity:	297/729 - (40%)
Similarity:	434/729 - (59%)	Gaps:	99/729 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ENSWNLRIFITD---LALEKTMRVRGDQHIGGIMLQLVDPENPK-DWSDHALWWPARNVWLSRTK 66
            ::||.||:|:.:   .|...|:||.|:.||||::|::|:..|.| ||||||:||..:..||.:|.
Human    13 DSSWELRVFVGEEDPEAESVTLRVTGESHIGGVLLKIVEQINRKQDWSDHAIWWEQKRQWLLQTH 77

  Fly    67 LTLDQCGVQADSLLHFTPMHKILRVQLPDLRYLDSRVDYSVKTFSAVVNLCKQLDIRYPEELSLC 131
            .|||:.|:.||:.|.|.|.|:.:.::||:.|.|..|..:|...|.||..:|:.|.||:||||||.
Human    78 WTLDKYGILADARLFFGPQHRPVILRLPNRRALRLRASFSQPLFQAVAAICRLLSIRHPEELSLL 142

  Fly   132 KPLEAEHLKRNFAQVPHQKRVPIAEPDGTTYLQPAADTNSFVPISTSFHGEGGSTGSLDKPSAPG 196
            :..|.:..|:.      :|     ||:...|     |.:..|.       .||        .||.
Human   143 RAPEKKEKKKK------EK-----EPEEELY-----DLSKVVL-------AGG--------VAPA 176

  Fly   197 SFFCAPLSPHNHRARSPVRTVSPFPGTWKQSQLGYATYDSSSSSLGDFQENLASSPPTPCADVRA 261
            .|                   ...|..:..|....|.|...|.             |.|..|...
Human   177 LF-------------------RGMPAHFSDSAQTEACYHMLSR-------------PQPPPDPLL 209

  Fly   262 LQL--RPKSLVEKARLNVGWLDSSLSIMEQGIREYDTLCLRFKYFTFFDLNPKCDQVRINQLYEQ 324
            ||.  ||.||.:|.:|:..|||||..:|:|||:..|.|.|||||::||||:||.|.||:.|||||
Human   210 LQRLPRPSSLSDKTQLHSRWLDSSRCLMQQGIKAGDALWLRFKYYSFFDLDPKTDPVRLTQLYEQ 274

  Fly   325 AKWSVLNEELDCTEEESLMFAALQFQVN--HHVDHTPQGAAVDSGIETSSQENDNEDEIDSALKE 387
            |:|.:|.||:||||||.::|||||:.:|  .......:.|..|.|:          |::|.||..
Human   275 ARWDLLLEEIDCTEEEMMVFAALQYHINKLSQSGEVGEPAGTDPGL----------DDLDVALSN 329

  Fly   388 LQITLEGPDYGGDSRNITRIPELSDYLRYL----KPQRFTLRGYKRYYFTYRDLHLHLFKNAEDS 448
            |::.|||........::|.||||.|:||..    :|::.||:||::::..:::..|..:| ::|.
Human   330 LEVKLEGSAPTDVLDSLTTIPELKDHLRIFRIPRRPRKLTLKGYRQHWVVFKETTLSYYK-SQDE 393

  Fly   449 RRVAPAISINLKGCEVTPDVNLSQGKYAIRLEV-SPDGGHGINSEVWVRCENEQQYAKWMAACRL 512
            ....|...:|||||||.||||:|..|:.|:|.| ||:|    .||:::||::|||||:|||.|||
Human   394 APGDPIQQLNLKGCEVVPDVNVSGQKFCIKLLVPSPEG----MSEIYLRCQDEQQYARWMAGCRL 454

  Fly   513 AAKGRSLADSSYESEVDSILSLLQMQRPAH---GVHVNIDPRSVEAVD---YLSPKIIRKLSNKA 571
            |:|||::|||||.|||.:||:.|.:||...   |.|.:....|.|.::   .::|:..||...|.
Human   455 ASKGRTMADSSYTSEVQAILAFLSLQRTGSGGPGNHPHGPDASAEGLNPYGLVAPRFQRKFKAKQ 519

  Fly   572 V-QRILEAHANVRELNALDSKLKYIQAWRSLPDFGVSLFIIKFDGHRKEELLGVAHNRIMRMDLS 635
            : .||||||.||.:|:..:::|::||||:||||||:|..:::|.|.||:|:||:|:||::|:||:
Human   520 LTPRILEAHQNVAQLSLAEAQLRFIQAWQSLPDFGISYVMVRFKGSRKDEILGIANNRLIRIDLA 584

  Fly   636 SGDHIKTWRYNTMKAWNVNWNIKCMMIQFEDE-NVVFSCHSADCKVVHEFIGGYIFMSMRSKDTN 699
            .||.:||||::.|:.|||||:|:.:.|:|::. ||.|||.||.|::|||:||||||:|.|.:...
Human   585 VGDVVKTWRFSNMRQWNVNWDIRQVAIEFDEHINVAFSCVSASCRIVHEYIGGYIFLSTRERARG 649

  Fly   700 QTLNEELFHKLTGG 713
            :.|:|:||.:||||
Human   650 EELDEDLFLQLTGG 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fit2	NP_648947.1	B41	259..>351	CDD:214604	54/93 (58%)
		FERM_M	310..>365	CDD:278785	28/56 (50%)
		PH_fermitin	408..536	CDD:269943	63/132 (48%)
		PH	408..515	CDD:278594	50/111 (45%)
		FERM_M	<557..609	CDD:278785	25/55 (45%)
		FERM_C_fermitin	603..693	CDD:270026	49/90 (54%)
FERMT3	NP_001369291.1	FERM_F0_KIND3	15..97	CDD:340702	38/81 (47%)
		FERM_F1_KIND3	98..254	CDD:340705	63/218 (29%)
		B41	<218..>315	CDD:214604	51/96 (53%)
		PH_fermitin	350..478	CDD:269943	63/132 (48%)
		FERM_M	<467..557	CDD:395297	36/89 (40%)
		FERM_C_fermitin	552..643	CDD:270026	49/90 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156363
Domainoid	1	1.000	298	1.000	Domainoid score	I1454
eggNOG	1	0.900	-	-		E1_KOG3727
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	636	1.000	Inparanoid score	I828
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132272at33208
OrthoFinder	1	1.000	-	-		FOG0001455
OrthoInspector	1	1.000	-	-		mtm8583
orthoMCL	1	0.900	-	-		OOG6_103097
Panther	1	1.100	-	-	O	PTHR16160
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X911
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.760