DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Fit2 and TLN2

DIOPT Version :9

Sequence 1:NP_648947.1 Gene:Fit2 / 39907 FlyBaseID:FBgn0036688 Length:715 Species:Drosophila melanogaster
Sequence 2:XP_005254765.1 Gene:TLN2 / 83660 HGNCID:15447 Length:2557 Species:Homo sapiens


Alignment Length:727 Identity:124/727 - (17%)
Similarity:216/727 - (29%) Gaps:337/727 - (46%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 NLRIFITDLALEKTMRVRGDQHIGG---IMLQLVDPENPKDWSDHALWW----PARNVWLSRTKL 67
            :|:|.:....:.|||:......:..   ::.:.|........||:.|:.    |.:.:||...: 
Human     5 SLKICVRHCNVVKTMQFEPSTAVYDACRVIRERVPEAQTGQASDYGLFLSDEDPRKGIWLEAGR- 68

  Fly    68 TLDQCGVQADSLLHFTPMHKILRVQLPDLRYLDSRVDYSVKTFSAVVNLCKQLDIRYPEELSLCK 132
            |||...::...:|.:....:..::::.|.......||.|......:|.:|.::.|...||.||. 
Human    69 TLDYYMLRNGDILEYKKKQRPQKIRMLDGSVKTVMVDDSKTVGELLVTICSRIGITNYEEYSLI- 132

  Fly   133 PLEAEHLKRNFAQVPHQKRVPIAEPDGTTYLQPAADTNSFVPISTSFHGEGGSTGSLDKPSAPGS 197
                            |:.:...:.:|                          ||:|.|.     
Human   133 ----------------QETIEEKKEEG--------------------------TGTLKKD----- 150

  Fly   198 FFCAPLSPHNHRARSPVRTVSPFPGTWKQSQLGYATYDSSSSSLGDFQENLASSPPTPCADVRAL 262
                             ||:                                             
Human   151 -----------------RTL--------------------------------------------- 153

  Fly   263 QLRPKSLVE--KARL----NVGWLDSSLSIMEQGIREYDTLCLRFKYFTFFDLN-PKCDQVRINQ 320
             ||.:..:|  ||:|    ::.|||.|.:..|||:.|.:||.||.|:| :.|.| ...|.|::|.
Human   154 -LRDERKMEKLKAKLHTDDDLNWLDHSRTFREQGVDENETLLLRRKFF-YSDQNVDSRDPVQLNL 216

  Fly   321 LYEQAKWSVLNEELDCTEEESLMFAALQFQVNH--HVDHTPQGAAVDSGIETSSQENDNEDEIDS 383
            ||.||:..:||.....:.|::..|...|.|:..  ||:|..:...:|                  
Human   217 LYVQARDDILNGSHPVSFEKACEFGGFQAQIQFGPHVEHKHKPGFLD------------------ 263

  Fly   384 ALKELQITLEGPDYGGDSRNITRIPELSDYLRYLKPQRFTLRGYKRYYFTYRDLHLHLFKNAEDS 448
             |||.                  :|:     .|:|.     ||                      
Human   264 -LKEF------------------LPK-----EYIKQ-----RG---------------------- 277

  Fly   449 RRVAPAISINLKGCEVTPDVNLSQGKYAIRLEVSPDGGHGINSEVWVRCENEQQYAKWMAACRLA 513
                                                                             
Human   278 ----------------------------------------------------------------- 277

  Fly   514 AKGRSLADSSYESEVDSILSLLQMQRPAHGVHVNIDPRSVEAVDYLSPKIIRKLSNKAVQRILEA 578
                                                                     |.:||.:.
Human   278 ---------------------------------------------------------AEKRIFQE 285

  Fly   579 HANVRELNALDSKLKYIQAWRSLPDFGVSLFII--KFDGHRK--EELLGVAHNRIMRMDLSSGDH 639
            |.|..|::.:::|:||::..|||..:|||.|::  |..|..|  ..|||:..:.:||:|..:.:.
Human   286 HKNCGEMSEIEAKVKYVKLARSLRTYGVSFFLVKEKMKGKNKLVPRLLGITKDSVMRVDEKTKEV 350

  Fly   640 IKTWRYNTMKAWNVNWNIKCMMIQF-EDENVVFSCHSADCKVVHEFIGGYIFMSMRSK------- 696
            ::.|...|:|.|..  :.|...:.| |.:...:|..:.:.:.:.:.|.|||.:.::.|       
Human   351 LQEWPLTTVKRWAA--SPKSFTLDFGEYQESYYSVQTTEGEQISQLIAGYIDIILKKKQSKDRFG 413

  Fly   697 ---DTNQTLNEE 705
               |...|:.||
Human   414 LEGDEESTMLEE 425

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fit2NP_648947.1 B41 259..>351 CDD:214604 34/98 (35%)
FERM_M 310..>365 CDD:278785 17/57 (30%)
PH_fermitin 408..536 CDD:269943 5/127 (4%)
PH 408..515 CDD:278594 5/106 (5%)
FERM_M <557..609 CDD:278785 15/51 (29%)
FERM_C_fermitin 603..693 CDD:270026 25/94 (27%)
TLN2XP_005254765.1 FERM_f0 4..85 CDD:318667 16/80 (20%)
B41 90..316 CDD:214604 81/528 (15%)
FERM_C_Talin 312..403 CDD:269973 25/92 (27%)
Talin_middle 494..655 CDD:312608
I_LWEQ 706..842 CDD:327626
talin-RS 1045..>1174 CDD:213393
talin-RS 1656..1827 CDD:213393
VBS 1850..1974 CDD:312463
ILWEQ 2337..2547 CDD:214607
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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