DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fit2 and pik3r5

DIOPT Version :9

Sequence 1:	NP_648947.1	Gene:	Fit2 / 39907	FlyBaseID:	FBgn0036688	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_001039143.1	Gene:	pik3r5 / 733968	XenbaseID:	XB-GENE-1015957	Length:	877	Species:	Xenopus tropicalis

Alignment Length:	369	Identity:	78/369 - (21%)
Similarity:	127/369 - (34%)	Gaps:	107/369 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 HRARSPVRT----------VSPFPGTWKQSQLGYATYDSSSSSLGDFQENLASSPPTP-CADVRA 261
            |:|:..::.          :||||...|...|                 ..|.|..|| .:.:..
Frog   427 HQAKGKLKAELSPCISHPLLSPFPDLSKTIPL-----------------RRAGSMYTPQVSRIPV 474

  Fly   262 LQLRPKSLVEKARLNVGWLDSSLSIMEQGIREYDTLCLRFKYFTFFDLNPKCDQV---------- 316
            ...|.|||.:.| |...:|:..||..           :.||...|.    .||:.
Frog   475 RSKRSKSLPQHA-LGTQFLEVQLSQK-----------VAFKRRPFL----SCDEETKVSTLRVVV 523

  Fly   317 ----RINQLYEQAKWSVLNEELDCTEEESLM--FAALQFQVNHHVDHTPQGAAVDSGIETSSQEN 375
                ||:....:|..::..:|..|    .|:  |..|||.      :.|..       .:||..|
Frog   524 FGSDRISGKVARAYSNLRLKESSC----PLLTRFFKLQFY------YVPVK-------RSSSSPN 571

  Fly   376 DNEDEIDSALKELQITLEGP--DYGGDSRNITRIPELSDYLRYLKPQRFTLRGYKRYYFTYRDLH 438
            ......:|.||....:...|  |..||..:..   ::|.|:..|.|      .|||......||.
Frog   572 APLTNAESPLKSPSPSGRSPLEDIFGDEGSTN---DISHYIGILDP------WYKRNIMGLMDLS 627

  Fly   439 LHLF--KNAEDSRRVAPAISINLKGCEVTPDVNLSQGKYAIR--------LEVSPDGGHGINSEV 493
            ..:.  |:::.........::     .:..|:.|...::|.|        .|::.||| |..:||
Frog   628 TSMLCQKSSKPENEATETTTM-----PILADMVLYYCRFATRSLLLQLYQAEITFDGG-GKQTEV 686

  Fly   494 WVRCENEQQYAKWMAACRLAAKGRSLADSSYESEVDSILSLLQM 537
            :::| .|..::..:.|.|  |.|........:.:.|:|...||:
Frog   687 FIQC-LELGHSAALRAIR--ASGPGCKRLGIDGDRDAIPFTLQI 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fit2	NP_648947.1	B41	259..>351	CDD:214604	24/107 (22%)
		FERM_M	310..>365	CDD:278785	13/70 (19%)
		PH_fermitin	408..536	CDD:269943	29/137 (21%)
		PH	408..515	CDD:278594	25/116 (22%)
		FERM_M	<557..609	CDD:278785
		FERM_C_fermitin	603..693	CDD:270026
pik3r5	NP_001039143.1	PI3K_1B_p101	4..877	CDD:371084	78/369 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165174275
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930