DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fit2 and fermt2

DIOPT Version :9

Sequence 1:	NP_648947.1	Gene:	Fit2 / 39907	FlyBaseID:	FBgn0036688	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_005158972.1	Gene:	fermt2 / 553051	ZFINID:	ZDB-GENE-050506-132	Length:	695	Species:	Danio rerio

Alignment Length:	733	Identity:	316/733 - (43%)
Similarity:	474/733 - (64%)	Gaps:	77/733 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ENSWNLRIFITDLALEKTMRVRGDQHIGGIMLQLVDP-ENPKDWSDHALWWPARNVWLSRTKLTL 69
            :.:|.|::.:|||..:.::||.|:.||||:||:||:. :..||||||||||..:..||.:|..||
Zfish    15 DGTWELKMHVTDLNRDVSLRVTGEIHIGGVMLKLVEKLDVKKDWSDHALWWEKKKTWLLKTHWTL 79

  Fly    70 DQCGVQADSLLHFTPMHKILRVQLPDLRYLDSRVDYSVKTFSAVVNLCKQLDIRYPEELSLC-KP 133
            |:.|:|||:.|.|||.||:||:|||:::::..:|::|.:.|.||.::||..:||:||||||. ||
Zfish    80 DKYGIQADARLLFTPQHKLLRLQLPNMKHMRVKVNFSDRVFKAVSDICKTFNIRHPEELSLLRKP 144

  Fly   134 LEAEHLKRNFAQVPHQK---RVPIAEPDGTTYLQPAADTNSFVPISTSFHGEGGSTGSLDKPSAP 195
            .:.:..|:.......:.   ..|:..|..      |:|.....|:..|.:            |:|
Zfish   145 RDPKKKKKKLEDAEEETLELEGPLLTPGS------ASDVLYIGPVKGSIY------------SSP 191

  Fly   196 GSFFCAPLSPHNHRARSPVRTVSPFPGTWKQSQLGYATYDSSSSSLGDFQENLASSPPTPCADVR 260
            |.:.......::.|..||:...|    .|    .|.:.....:.|:      ||.|.|....|:.
Zfish   192 GLYSKTMTPTYDSRDGSPLSPTS----AW----FGDSPLSEGNPSI------LAVSQPITSPDIL 242

  Fly   261 ALQLRPKSLVEKARLNVGWLDSSLSIMEQGIREYDTLCLRFKYFTFFDLNPKCDQVRINQLYEQA 325
            ....:|:||::||::|.||||||.|:|||.::|.:.|.|||||.:|||||||.|.:|:|||||||
Zfish   243 VKMYKPQSLLDKAKINQGWLDSSRSLMEQDVKENEVLLLRFKYHSFFDLNPKYDAIRVNQLYEQA 307

  Fly   326 KWSVLNEELDCTEEESLMFAALQFQVNHHVDHTPQGAAVDSGIETSSQENDNE---DEIDSALKE 387
            ||::|.||::|||||.:||||||:.:|..           |.:.:.:..|::|   ||:|:||.:
Zfish   308 KWAILLEEIECTEEEMMMFAALQYHINKL-----------SIMSSDNHMNNSEKEVDEVDAALSD 361

  Fly   388 LQITLEGPDYGGDSRNITRIPELSDYLRYLKPQRFTLRGYKRYYFTYRDLHLHLFKNAEDSRRVA 452
            |:|||||........:||.||||:||::..||::.||:|||:|:.|::|:.:..:|:.|::.. .
Zfish   362 LEITLEGGKTSNTLGDITSIPELADYVKVFKPKKLTLKGYKQYWCTFKDITISCYKSREEAHG-T 425

  Fly   453 PAISINLKGCEVTPDVNLSQGKYAIRLEVSPDGGHGINSEVWVRCENEQQYAKWMAACRLAAKGR 517
            ||..:||:|||||||||:|..|:.|:|.:..  ..|:| |:|:||:.|:|||:||||||||:||:
Zfish   426 PAHQMNLRGCEVTPDVNISGQKFNIKLLIPV--ADGMN-EIWLRCDTEKQYAQWMAACRLASKGK 487

  Fly   518 SLADSSYESEVDSILSLLQMQRPAHGVHVNIDPRSVEAVD-------YLSPKIIRKLSNK----- 570
            ::|||||..||.:|||.|:||      |:|.||:.:|.:.       .:||:.::|..||
Zfish   488 TMADSSYNLEVQNILSFLKMQ------HMNPDPQIIEPITTDINPECLVSPRYLKKYKNKQPGFV 546

  Fly   571 ---AVQRILEAHANVRELNALDSKLKYIQAWRSLPDFGVSLFIIKFDGHRKEELLGVAHNRIMRM 632
               ...||||||.||.:::.:::|:::||||:|||:||::.|:.||.|.:|:||:|:.:||::||
Zfish   547 RDLISARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFLAKFQGGKKDELIGITYNRLIRM 611

  Fly   633 DLSSGDHIKTWRYNTMKAWNVNWNIKCMMIQFEDE-NVVFSCHSADCKVVHEFIGGYIFMSMRSK 696
            |..:||.|||||::.||.|||||.||.:.::|.|| ::.|.|...||||||||||||||:|.|:|
Zfish   612 DAGTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEPSLAFICAEVDCKVVHEFIGGYIFLSTRAK 676

  Fly   697 DTNQTLNEELFHKLTGGW 714
            |.|::|:||:|:|||.||
Zfish   677 DQNESLDEEMFYKLTSGW 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fit2	NP_648947.1	B41	259..>351	CDD:214604	55/91 (60%)
		FERM_M	310..>365	CDD:278785	29/54 (54%)
		PH_fermitin	408..536	CDD:269943	64/127 (50%)
		PH	408..515	CDD:278594	52/106 (49%)
		FERM_M	<557..609	CDD:278785	23/66 (35%)
		FERM_C_fermitin	603..693	CDD:270026	50/90 (56%)
fermt2	XP_005158972.1	FERM_B-lobe	292..>335	CDD:298919	28/42 (67%)
		PH_fermitin	382..506	CDD:269943	64/127 (50%)
		PH	390..485	CDD:278594	47/98 (48%)
		FERM_M	<524..588	CDD:278785	23/63 (37%)
		PH-like	582..673	CDD:302622	50/90 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591971
Domainoid	1	1.000	297	1.000	Domainoid score	I1426
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4976
Inparanoid	1	1.050	630	1.000	Inparanoid score	I825
OMA	1	1.010	-	-		QHG48345
OrthoDB	1	1.010	-	-		D132272at33208
OrthoFinder	1	1.000	-	-		FOG0001455
OrthoInspector	1	1.000	-	-		mtm6417
orthoMCL	1	0.900	-	-		OOG6_103097
Panther	1	1.100	-	-	O	PTHR16160
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X911
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870