Protein Alignment Fit2 and fermt2

DIOPT Version :10

• Sequence 1: NP_648947.1
• Gene: Fit2 / 39907
• FlyBaseID: FBgn0036688
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: XP_005158972.1
• Gene: fermt2 / 553051
• ZFINID: ZDB-GENE-050506-132
• Length: 695
• Species: Danio rerio
• Alignment Length: 733
• Identity: 316/733 - (43%)
• Similarity: 474/733 - (64%)
• Gaps: 77/733 - (10%)

  Fly     6 ENSWNLRIFITDLALEKTMRVRGDQHIGGIMLQLVDP-ENPKDWSDHALWWPARNVWLSRTKLTL 69
            :.:|.|::.:|||..:.::||.|:.||||:||:||:. :..||||||||||..:..||.:|..||
Zfish    15 DGTWELKMHVTDLNRDVSLRVTGEIHIGGVMLKLVEKLDVKKDWSDHALWWEKKKTWLLKTHWTL 79

  Fly    70 DQCGVQADSLLHFTPMHKILRVQLPDLRYLDSRVDYSVKTFSAVVNLCKQLDIRYPEELSLC-KP 133
            |:.|:|||:.|.|||.||:||:|||:::::..:|::|.:.|.||.::||..:||:||||||. ||
Zfish    80 DKYGIQADARLLFTPQHKLLRLQLPNMKHMRVKVNFSDRVFKAVSDICKTFNIRHPEELSLLRKP 144

  Fly   134 LEAEHLKRNFAQVPHQK---RVPIAEPDGTTYLQPAADTNSFVPISTSFHGEGGSTGSLDKPSAP 195
            .:.:..|:.......:.   ..|:..|..      |:|.....|:..|.:            |:|
Zfish   145 RDPKKKKKKLEDAEEETLELEGPLLTPGS------ASDVLYIGPVKGSIY------------SSP 191

  Fly   196 GSFFCAPLSPHNHRARSPVRTVSPFPGTWKQSQLGYATYDSSSSSLGDFQENLASSPPTPCADVR 260
            |.:.......::.|..||:...|    .|    .|.:.....:.|:      ||.|.|....|:.
Zfish   192 GLYSKTMTPTYDSRDGSPLSPTS----AW----FGDSPLSEGNPSI------LAVSQPITSPDIL 242

  Fly   261 ALQLRPKSLVEKARLNVGWLDSSLSIMEQGIREYDTLCLRFKYFTFFDLNPKCDQVRINQLYEQA 325
            ....:|:||::||::|.||||||.|:|||.::|.:.|.|||||.:|||||||.|.:|:|||||||
Zfish   243 VKMYKPQSLLDKAKINQGWLDSSRSLMEQDVKENEVLLLRFKYHSFFDLNPKYDAIRVNQLYEQA 307

  Fly   326 KWSVLNEELDCTEEESLMFAALQFQVNHHVDHTPQGAAVDSGIETSSQENDNE---DEIDSALKE 387
            ||::|.||::|||||.:||||||:.:|..           |.:.:.:..|::|   ||:|:||.:
Zfish   308 KWAILLEEIECTEEEMMMFAALQYHINKL-----------SIMSSDNHMNNSEKEVDEVDAALSD 361

  Fly   388 LQITLEGPDYGGDSRNITRIPELSDYLRYLKPQRFTLRGYKRYYFTYRDLHLHLFKNAEDSRRVA 452
            |:|||||........:||.||||:||::..||::.||:|||:|:.|::|:.:..:|:.|::.. .
Zfish   362 LEITLEGGKTSNTLGDITSIPELADYVKVFKPKKLTLKGYKQYWCTFKDITISCYKSREEAHG-T 425

  Fly   453 PAISINLKGCEVTPDVNLSQGKYAIRLEVSPDGGHGINSEVWVRCENEQQYAKWMAACRLAAKGR 517
            ||..:||:|||||||||:|..|:.|:|.:..  ..|:| |:|:||:.|:|||:||||||||:||:
Zfish   426 PAHQMNLRGCEVTPDVNISGQKFNIKLLIPV--ADGMN-EIWLRCDTEKQYAQWMAACRLASKGK 487

  Fly   518 SLADSSYESEVDSILSLLQMQRPAHGVHVNIDPRSVEAVD-------YLSPKIIRKLSNK----- 570
            ::|||||..||.:|||.|:||      |:|.||:.:|.:.       .:||:.::|..||
Zfish   488 TMADSSYNLEVQNILSFLKMQ------HMNPDPQIIEPITTDINPECLVSPRYLKKYKNKQPGFV 546

  Fly   571 ---AVQRILEAHANVRELNALDSKLKYIQAWRSLPDFGVSLFIIKFDGHRKEELLGVAHNRIMRM 632
               ...||||||.||.:::.:::|:::||||:|||:||::.|:.||.|.:|:||:|:.:||::||
Zfish   547 RDLISARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFLAKFQGGKKDELIGITYNRLIRM 611

  Fly   633 DLSSGDHIKTWRYNTMKAWNVNWNIKCMMIQFEDE-NVVFSCHSADCKVVHEFIGGYIFMSMRSK 696
            |..:||.|||||::.||.|||||.||.:.::|.|| ::.|.|...||||||||||||||:|.|:|
Zfish   612 DAGTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEPSLAFICAEVDCKVVHEFIGGYIFLSTRAK 676

  Fly   697 DTNQTLNEELFHKLTGGW 714
            |.|::|:||:|:|||.||
Zfish   677 DQNESLDEEMFYKLTSGW 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fit2	NP_648947.1	FERM_F0_kindlins	8..86	CDD:340615	40/78 (51%)
		FERM_F1_kindlins	87..304	CDD:340616	67/220 (30%)
		B41	259..>351	CDD:214604	55/91 (60%)
		PH_fermitin	408..536	CDD:269943	64/127 (50%)
		FERM_M	<507..609	CDD:459788	50/116 (43%)
		FERM_C_fermitin	603..693	CDD:270026	50/90 (56%)
fermt2	XP_005158972.1	FERM_F0_KIND2	17..96	CDD:340701	40/78 (51%)
		FERM_F1_KIND2	97..286	CDD:340704	67/220 (30%)
		B41	<253..>333	CDD:214604	52/79 (66%)
		PH_fermitin	382..506	CDD:269943	64/127 (50%)
		FERM_M	<464..588	CDD:459788	58/129 (45%)
		PH-like	582..673	CDD:473070	50/90 (56%)