DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fit2 and Ptpn3

DIOPT Version :9

Sequence 1:	NP_648947.1	Gene:	Fit2 / 39907	FlyBaseID:	FBgn0036688	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_006538160.1	Gene:	Ptpn3 / 545622	MGIID:	105307	Length:	935	Species:	Mus musculus

Alignment Length:	852	Identity:	155/852 - (18%)
Similarity:	261/852 - (30%)	Gaps:	294/852 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 PMHKILRVQLPDLRYLDSRVDYSVKTFSAVVNLCKQ------LDIRY------------------ 124
            |..|.....:..:|:||.    .|:||.  ||  ||      ||:.|
Mouse    43 PKEKTRSEVICSIRFLDG----LVQTFK--VN--KQDLGQSLLDMAYGHLGVTEKEYFGLQHGDD 99

  Fly   125 ----PEELSLCKPLEAEHLKRNFAQVPHQKRVPIAEPDGTTYLQPAADTNSFVPISTSFHGEGGS 185
                |..|...|||. :.||..|....| .||....||..|..|.......|:.:.... .||..
Mouse   100 PVDSPRWLEASKPLR-KQLKGGFPCTLH-FRVRYFIPDPNTLQQEQTRHLYFLQLKMDV-CEGRL 161

  Fly   186 TGSLDKPSAPGSFFCAPLSPHNHRARSPVRTVSPFPGTWKQSQLGYATYD---SSSSSLGDFQEN 247
            |..|:......|:   .:..|.....|.:.    .||....||......|   |...||.:....
Mouse   162 TCPLNSAVVLASY---AVQSHFGDFNSSIH----HPGYLADSQFIPDQNDDFLSKVESLHEQHSG 219

  Fly   248 LASSPPTPC-------ADVRALQLRPKSLVEKARLNVGWLDSSLSIMEQGIREYDTLCLRF-KYF 304
            |..|....|       .|...::|.....:....|.:|...:.:::    .|:|  :|..| .:.
Mouse   220 LKQSEAESCYINIARTLDFYGVELHGGRDLHNLDLMIGIASAGIAV----YRKY--ICTSFYPWV 278

  Fly   305 TFFDLNPKCDQVRINQLYEQAKWSVLNEELDCTEEESLMFAALQFQ---------VNHH-----V 355
            ....::.|..:..|:|..:||:          :.|..:.|..|.::         |.||     .
Mouse   279 NILKISFKRKKFFIHQRQKQAE----------SREHIVAFNMLNYRSCKNLWKSCVEHHSFFQAK 333

  Fly   356 DHTPQGAAVDSGIETSSQENDNEDEIDSALKE--------------LQI-TLEGPDYGGDSRNIT 405
            ...||...|.|...|....|..:...:...|:              |.: .||.......|..||
Mouse   334 KLLPQEKNVLSQYWTLGSRNPKKSVNNQYCKKVIGGMVWNPVMRRSLSVERLETKSLPSRSPPIT 398

  Fly   406 ---RIPELSDYLRYLKPQRFT---LRGYKRY-------YFTYRDLHLHLFKNAEDSRRVAP---A 454
               |.|.|...:|  ||:..:   |.....|       ::||:........::|.|:..:|   :
Mouse   399 PNWRSPRLRHEIR--KPRHSSADNLANEMTYITETEDVFYTYKGPLSPKDSDSEVSQNHSPHRES 461

  Fly   455 ISIN--LKGC-------EVTPDVN--------------------LSQG----------------- 473
            :|.|  .:.|       .|:|..|                    :::|
Mouse   462 LSENNPAQSCLTQKSSSSVSPSSNAPGSCSPDGVDQRFLEDYHKVTKGGFVEDASQYYCDKSDDG 526

  Fly   474 -KYAIRLEVSPD--GGHGINSE---------VWVRCENEQQYAKWMAACR-----LAAKGRSLAD 521
             .|.:.:.::||  |..|.|.:         |..|...|......|....     :...||.:::
Mouse   527 DGYLVLIRITPDEEGRFGFNLKGGVDQKMPLVVSRINPESPADTCMPKLNEGDQIVLINGRDISE 591

  Fly   522 SSYESEVDSILSLLQMQRPAHGVHVNIDPRSVEAVDYLSPKIIRKLSNKAVQRILEAHANVRELN 586
            .::    |.::..::..|.:|...:.:              :||:   |||:.:.|..:. .||:
Mouse   592 HTH----DQVVMFIKASRESHSRELAL--------------VIRR---KAVRSLAEIRSE-DELS 634

  Fly   587 AL-------------DS-----------------KLKYIQAWRSLPDFGVSLFII--KFDGHRKE 619
            .|             ||                 .:::.|.:|..|...||...:  ..|.:|.:
Mouse   635 QLFPEAMFPACPEGGDSLEGSMELLKKGLESGTVLIQFEQLYRKKPGLAVSFAKLPQNLDKNRYK 699

  Fly   620 ELLGVAHNRIM-------------RMDLSSGDHIKTWRY--------NT-MKAWNVNWNIKCMMI 662
            ::|.....|::             .|::.:.:.:.  :|        || .:.|.|.|:.|..::
Mouse   700 DVLPYDTTRVLLQGNEDYINASYVNMEMPAANLVN--KYIATQGPLPNTCAQFWQVVWDQKLSLV 762

  Fly   663 ----------------------QFEDENVV-FSCHSADCKVVHEFIGGYIFMSMRSKDTNQTLNE 704
                                  ...|..:. ..|.:.||.:.        ::|.....||....|
Mouse   763 VMLTTLTERGRTKCHQYWPDPPDIMDHGIFHIQCQTEDCTIA--------YVSREMLVTNTETGE 819

  Fly   705 ELFHKLT 711
            |  |.:|
Mouse   820 E--HTVT 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fit2	NP_648947.1	B41	259..>351	CDD:214604	15/101 (15%)
		FERM_M	310..>365	CDD:278785	13/68 (19%)
		PH_fermitin	408..536	CDD:269943	32/203 (16%)
		PH	408..515	CDD:278594	29/182 (16%)
		FERM_M	<557..609	CDD:278785	16/81 (20%)
		FERM_C_fermitin	603..693	CDD:270026	18/136 (13%)
Ptpn3	XP_006538160.1	B41	53..244	CDD:214604	48/208 (23%)
		FERM_C_PTPN4_PTPN3_like	238..331	CDD:270010	18/108 (17%)
		PDZ_signaling	530..617	CDD:238492	14/104 (13%)
		PTPc-N3	653..926	CDD:350448	28/184 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910