DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fit2 and tln1

DIOPT Version :9

Sequence 1:	NP_648947.1	Gene:	Fit2 / 39907	FlyBaseID:	FBgn0036688	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_021334842.1	Gene:	tln1 / 494453	ZFINID:	ZDB-GENE-031002-48	Length:	2561	Species:	Danio rerio

Alignment Length:	688	Identity:	109/688 - (15%)
Similarity:	190/688 - (27%)	Gaps:	325/688 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 QLVDPENPKDWSDHALWW----PARNVWLSRTKLTLDQCGVQADSLLHFTPMHKILRVQLPDLRY 98
            ||..|      ||:.|:.    |.:.:||...| .||...::....|.:....:.|::::.|...
Zfish    40 QLGQP------SDYGLFLSDDDPKKGIWLEAGK-ALDYYMLRNGDTLEYKKKQRPLKIRMLDGTV 97

  Fly    99 LDSRVDYSVKTFSAVVNLCKQLDIRYPEELSLCKPLEAEHLKRNFAQVPHQKRVPIAEPDGTTYL 163
            ....||.|......::.:|.::.|...:|.||.:.:..|                  :.:.||
Zfish    98 KTVMVDDSKIVSDMLMTICARIGITNYDEYSLVRDVGEE------------------KKEETT-- 142

  Fly   164 QPAADTNSFVPISTSFHGEGGSTGSLDKPSAPGSFFCAPLSPHNHRARSPVRTVSPFPGTWKQSQ 228
                                                                      ||.|:.:
Zfish   143 ----------------------------------------------------------GTLKRDK 149

  Fly   229 LGYATYDSSSSSLGDFQENLASSPPTPCADVRALQLRPKSLVEKARLNVGWLDSSLSIMEQGIRE 293
                                     |...|.:.::...:.|.....||  |||...::.|||:.|
Zfish   150 -------------------------TLLRDDKKMEKLKQKLHTDDELN--WLDHGRTLREQGVEE 187

  Fly   294 YDTLCLRFKYFTFFDLN-PKCDQVRINQLYEQAKWSVLNEELDCTEEESLMFAALQFQVNHHVDH 357
            .:.|.||.|:| :.|.| ...|.|::|.||.||:..:||.....:.:::..||..|.|:..
Zfish   188 SEMLLLRRKFF-YSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFAGYQCQIQF---- 247

  Fly   358 TPQGAAVDSGIETSSQENDNEDEIDSALKELQITLEGPDYGGDSRNITRIPELSDYLRYLKPQRF 422
                                                     ||.......|...|...:|
Zfish   248 -----------------------------------------GDHNESKHKPGFLDLKEFL----- 266

  Fly   423 TLRGYKRYYFTYRDLHLHLFKNAEDSRRVAPAISINLKGCEVTPDVNLSQGKYAIRLEVSPDGGH 487

Zfish   267 ----------------------------------------------------------------- 266

  Fly   488 GINSEVWVRCENEQQYAKWMAACRLAAKGRSLADSSYESEVDSILSLLQMQRPAHGVHVNIDPRS 552
                        .::|.|
Zfish   267 ------------PKEYVK----------------------------------------------- 272

  Fly   553 VEAVDYLSPKIIRKLSNKAVQRILEAHANVRELNALDSKLKYIQAWRSLPDFGVSLFII--KFDG 615
                            ||..:||.:||.|.:.:..:::|:.|::..|||..:|||.|::  |..|
Zfish   273 ----------------NKGEKRIFQAHKNCQNMTEIEAKVNYVKLARSLKTYGVSFFLVKEKMKG 321

  Fly   616 HRK--EELLGVAHNRIMRMDLSSGDHIKTWRYNTMKAWNVNWNIKCMMIQFED-ENVVFSCHSAD 677
            ..|  ..|||:....:||:|..:.:.|:.|....:|.|..  :.|...:.|.| ::..:|..:.:
Zfish   322 KNKLVPRLLGITKESVMRVDEKTKEVIQEWSLTNIKRWAA--SPKSFTLDFGDYQDGYYSVQTTE 384

  Fly   678 CKVVHEFIGGYIFMSMRSK----------DTNQTLNEE 705
            .:.:.:.|.|||.:.::.|          |...|:.|:
Zfish   385 GEQIAQLIAGYIDIILKKKKSKDHFGLEGDEESTMLED 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fit2	NP_648947.1	B41	259..>351	CDD:214604	29/92 (32%)
		FERM_M	310..>365	CDD:278785	14/55 (25%)
		PH_fermitin	408..536	CDD:269943	5/127 (4%)
		PH	408..515	CDD:278594	5/106 (5%)
		FERM_M	<557..609	CDD:278785	15/51 (29%)
		FERM_C_fermitin	603..693	CDD:270026	25/94 (27%)
tln1	XP_021334842.1	FERM_f0	4..83	CDD:318667	13/49 (27%)
		B41	88..313	CDD:214604	70/520 (13%)
		FERM_C_Talin	309..400	CDD:269973	25/92 (27%)
		Talin_middle	491..652	CDD:312608
		VBS	1253..1369	CDD:312463
		talin-RS	1672..1843	CDD:213393
		VBS	1866..1990	CDD:312463
		talin-RS	1991..2156	CDD:213393
		ILWEQ	2354..2549	CDD:214607
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910