DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fit2 and fermt3

DIOPT Version :9

Sequence 1:	NP_648947.1	Gene:	Fit2 / 39907	FlyBaseID:	FBgn0036688	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_012816277.1	Gene:	fermt3 / 448215	XenbaseID:	XB-GENE-1013715	Length:	659	Species:	Xenopus tropicalis

Alignment Length:	718	Identity:	300/718 - (41%)
Similarity:	429/718 - (59%)	Gaps:	85/718 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ENSWNLRIFITDLALEK---TMRVRGDQHIGGIMLQLVDPEN-PKDWSDHALWWPARNVWLSRTK 66
            ::||.|:|::.|:..:.   |.||.|:.||||::||.|:... .:||||||:||..:..||.:|.
Frog    13 DSSWELKIYVEDMGPDADPVTFRVTGETHIGGVILQAVEKIGISQDWSDHAIWWQQKCQWLLKTS 77

  Fly    67 LTLDQCGVQADSLLHFTPMHKILRVQLPDLRYLDSRVDYSVKTFSAVVNLCKQLDIRYPEELSLC 131
            .|||:.||.||:.|.||..||.:.:.||:.|.|..||.:|..||||...:||.|.||||||||..
Frog    78 WTLDKYGVLADARLIFTSQHKPVILSLPNQRSLRIRVCFSSTTFSACAEVCKVLGIRYPEELSFL 142

  Fly   132 KPLEAEHLKRNFAQVPHQKRVPIA-EPDGTTYLQPAADTNSFVPISTSFHGEGGSTGSLDKPSAP 195
            |..|.:..|:       :|:.|:. |....|.|||:                .||...|.:...|
Frog   143 KAPEDKEKKK-------KKKDPVTQEIFDLTSLQPS----------------DGSAVLLQQGGIP 184

  Fly   196 GSFFCAPLSPHNHRARSPVRTVSPFPGTWKQSQLGYATYDSSSSSLGDFQENLASSPPTPCADVR 260
            ..|..:|.:...:||.|..:|..                                   || .|::
Frog   185 AHFLASPEAQEGYRALSVCQTAL-----------------------------------TP-EDIQ 213

  Fly   261 ALQLRPKSLVEKARLNVGWLDSSLSIMEQGIREYDTLCLRFKYFTFFDLNPKCDQVRINQLYEQA 325
            . :.:|.::.:|..::..||:||.|:|:||::|.|.|.|.|||:||.||:||.|.||||.|:|||
Frog   214 K-RYKPITVTDKTLIHGRWLNSSKSLMQQGVQEGDRLWLHFKYYTFHDLDPKLDVVRINLLFEQA 277

  Fly   326 KWSVLNEELDCTEEESLMFAALQFQVNH-HVDHTPQGAAVDSGIETSSQENDNEDEIDSALKELQ 389
            :|:||.||.:|||||.::|||||:.||. .|...|.....|..::          :::.||..|:
Frog   278 RWAVLLEETECTEEEMMVFAALQYHVNKLSVTSNPMDLPQDPALQ----------DLEEALSNLE 332

  Fly   390 ITLEGPDYGGDSRNITRIPELSDYLRYLKPQRFTLRGYKRYYFTYRDLHLHLFKNAEDSRRVAPA 454
            :.::..........|...|.|.:|||..:|::.||:|||:.:...:|.:|..:|:.|::|. .|.
Frog   333 VKMDANTPSEALEGIQLEPGLQEYLRVFRPKKMTLKGYKQNWVLLKDTNLSCYKSKEETRG-EPL 396

  Fly   455 ISINLKGCEVTPDVNLSQGKYAIRLEV-SPDGGHGINSEVWVRCENEQQYAKWMAACRLAAKGRS 518
            |...||||||.|:||:|..|:.|||.| :|:|    .:||::||::|||||:|||.||||||||:
Frog   397 IMFGLKGCEVIPEVNISSQKFCIRLLVPTPEG----MNEVYLRCDDEQQYARWMAGCRLAAKGRT 457

  Fly   519 LADSSYESEVDSILSLLQMQRPAHGVHVNIDPRSVEAVDYLSPKIIRKLSNKAV-QRILEAHANV 582
            :.|:|||.||.|:||.|.:|:............|:.....:||:..:||..|.: .|||||:.|:
Frog   458 MGDASYEGEVQSVLSFLNLQKSTTTQSNTTASDSINVHALVSPRFQKKLKPKQLTPRILEAYQNI 522

  Fly   583 RELNALDSKLKYIQAWRSLPDFGVSLFIIKFDGHRKEELLGVAHNRIMRMDLSSGDHIKTWRYNT 647
            .:|:.:|:|.::||||:||||||||.|:::|.|.|::|:||:|.||::|:|||.||.:|||.|:.
Frog   523 AQLSLIDAKQRFIQAWQSLPDFGVSYFLVRFKGSRRDEILGIASNRLIRIDLSVGDIVKTWMYSN 587

  Fly   648 MKAWNVNWNIKCMMIQF-EDENVVFSCHSADCKVVHEFIGGYIFMSMRSKD-TNQTLNEELFHKL 710
            ||.|||||:|:.:.|:| |..||.|:|.||.||||||:||||||||.|.|| .::||||||||||
Frog   588 MKQWNVNWDIRQVSIEFTEHINVAFTCVSAPCKVVHEYIGGYIFMSTRGKDGGSKTLNEELFHKL 652

  Fly   711 TGG 713
            |||
Frog   653 TGG 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fit2	NP_648947.1	B41	259..>351	CDD:214604	47/91 (52%)
		FERM_M	310..>365	CDD:278785	30/55 (55%)
		PH_fermitin	408..536	CDD:269943	64/128 (50%)
		PH	408..515	CDD:278594	51/107 (48%)
		FERM_M	<557..609	CDD:278785	26/52 (50%)
		FERM_C_fermitin	603..693	CDD:270026	55/90 (61%)
fermt3	XP_012816277.1	FERM_F0_KIND3	15..97	CDD:340702	37/81 (46%)
		FERM_F1_KIND3	98..256	CDD:340705	62/217 (29%)
		B41	<221..>303	CDD:214604	46/81 (57%)
		PH_fermitin	351..474	CDD:269943	64/127 (50%)
		FERM_M	<480..549	CDD:366056	27/68 (40%)
		FERM_C_fermitin	543..634	CDD:270026	55/90 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	296	1.000	Domainoid score	I1456
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	633	1.000	Inparanoid score	I827
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132272at33208
OrthoFinder	1	1.000	-	-		FOG0001455
OrthoInspector	1	1.000	-	-		mtm9477
Panther	1	1.100	-	-	O	PTHR16160
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X911
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160