DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fit2 and fermt3b

DIOPT Version :9

Sequence 1:	NP_648947.1	Gene:	Fit2 / 39907	FlyBaseID:	FBgn0036688	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_957198.2	Gene:	fermt3b / 393878	ZFINID:	ZDB-GENE-040426-1366	Length:	642	Species:	Danio rerio

Alignment Length:	722	Identity:	301/722 - (41%)
Similarity:	433/722 - (59%)	Gaps:	102/722 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SWNLRIFITDL---ALEKTMRVRGDQHIGGIMLQLVDPEN-PKDWSDHALWWPARNVWLSRTKLT 68
            :|:|.:.:.||   |....:.|..|.||||::|::|:... .||||||||||..:..||.||..|
Zfish     3 AWDLNVTVEDLGPDAPPLQISVTSDLHIGGVILKIVEKTMLKKDWSDHALWWEQKQQWLLRTGWT 67

  Fly    69 LDQCGVQADSLLHFTPMHKILRVQLPDLRYLDSRVDYSVKTFSAVVNLCKQLDIRYPEELSLCKP 133
            ||:|||.||:.|.|||.||.||:.||:...|..|..:|...|..|:.:|:.|:||:||||||.:|
Zfish    68 LDKCGVHADARLVFTPQHKPLRLGLPNGATLKMRACFSSPVFRCVMGICRVLNIRHPEELSLLRP 132

  Fly   134 LEAEHLKRNFAQVPHQKRVPIAEPDGTTYLQPAADTNSFVPISTSFHGEGGSTGSLDKPSAPGSF 198
            :|.:..|:              :.|.:..|....|    ||::      .||..:|
Zfish   133 VEEKKKKK--------------DKDSSEELYDLTD----VPLT------AGSVQAL--------- 164

  Fly   199 FCAPLSPHNHRARSPVRTVSPFPGTWKQSQLGYATYDSSSSSLGDFQENLASSPPTPCADVRALQ 263
                              .:..|..:..|....|.|...|.||           |:|..:..|..
Zfish   165 ------------------YNGMPAHFADSPKTEAVYKMLSFSL-----------PSPAPEAIAKL 200

  Fly   264 LRPKSLVEKARLNVGWLDSSLSIMEQGIREYDTLCLRFKYFTFFDLNPKCDQVRINQLYEQAKWS 328
            .||.|:|:|..::..|||||.|:|:|||:|.|.|.|||||:||.|::||.|.||:.||||||:|:
Zfish   201 YRPASVVDKTHIHTRWLDSSRSLMQQGIQENDKLWLRFKYYTFHDMDPKYDAVRLTQLYEQARWA 265

  Fly   329 VLNEELDCTEEESLMFAALQFQVNHHVDHTPQGAAVDSGIETSSQENDNE----DEIDSALKELQ 389
            ||.|::||||||.::|.|||:.:               |..::|||..:.    |:::||||.|:
Zfish   266 VLLEDIDCTEEEMMLFGALQYHI---------------GKLSTSQEIGSSCQGMDDLESALKSLE 315

  Fly   390 ITLEGPDYGGDSR-----NITRIPELSDYLRYLKPQRFTLRGYKRYYFTYRDLHLHLFKNAEDSR 449
            :.:.|.   |||.     |:|. |||:|||:..:|:|.||:|||:|:..::|..:..:|:.|| |
Zfish   316 VKMVGE---GDSTTDMLDNMTP-PELNDYLKIFRPKRLTLKGYKQYWCKFQDTSISYYKSMED-R 375

  Fly   450 RVAPAISINLKGCEVTPDVNLSQGKYAIRLEV-SPDGGHGINSEVWVRCENEQQYAKWMAACRLA 513
            ...|...:|||||||.||||::..|:.|:|.: :|:|    .:|:::|||||:||::|||.|:||
Zfish   376 YGEPIQQLNLKGCEVAPDVNIAGQKFCIKLLIPAPEG----MNEIYLRCENEKQYSEWMAGCKLA 436

  Fly   514 AKGRSLADSSYESEVDSILSLLQMQRPAHGVHVNIDPRSVEAVDYLSPKIIRKLSNKAV-QRILE 577
            :||.:|.||||::||.:|.:.|.|||............|:.....:||:..:|...|.: .||||
Zfish   437 SKGLTLLDSSYQNEVKNIQTFLSMQRSNSSTAAAQTDDSINTHSLVSPRYQKKYKPKQLTPRILE 501

  Fly   578 AHANVRELNALDSKLKYIQAWRSLPDFGVSLFIIKFDGHRKEELLGVAHNRIMRMDLSSGDHIKT 642
            |..||.:|:...:.||::|.|::|||||:|.|:::|.|.||:|:||:|:||::|:||..||.:||
Zfish   502 AFQNVAQLSLTSAILKFLQIWQALPDFGISYFMVRFKGSRKDEVLGIANNRLIRIDLGVGDVVKT 566

  Fly   643 WRYNTMKAWNVNWNIKCMMIQFEDE-NVVFSCHSADCKVVHEFIGGYIFMSMRSKDTNQTLNEEL 706
            ||||.|:.|||||:|:.:.|:|:.. |:.|||.:||||||||:||||||||.||:..:.||||||
Zfish   567 WRYNNMRQWNVNWDIRQVAIEFDGNINIAFSCVNADCKVVHEYIGGYIFMSTRSRQQSDTLNEEL 631

  Fly   707 FHKLTGG 713
            |||||||
Zfish   632 FHKLTGG 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fit2	NP_648947.1	B41	259..>351	CDD:214604	52/91 (57%)
		FERM_M	310..>365	CDD:278785	25/54 (46%)
		PH_fermitin	408..536	CDD:269943	60/128 (47%)
		PH	408..515	CDD:278594	50/107 (47%)
		FERM_M	<557..609	CDD:278785	22/52 (42%)
		FERM_C_fermitin	603..693	CDD:270026	54/90 (60%)
fermt3b	NP_957198.2	B41	<208..>288	CDD:214604	47/79 (59%)
		FERM_M	248..>317	CDD:278785	35/83 (42%)
		PH_fermitin	335..459	CDD:269943	60/128 (47%)
		PH	343..438	CDD:278594	44/99 (44%)
		FERM_M	<471..533	CDD:278785	23/61 (38%)
		FERM_C_fermitin	527..618	CDD:270026	54/90 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591970
Domainoid	1	1.000	297	1.000	Domainoid score	I1426
eggNOG	1	0.900	-	-		E1_KOG3727
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	630	1.000	Inparanoid score	I825
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132272at33208
OrthoFinder	1	1.000	-	-		FOG0001455
OrthoInspector	1	1.000	-	-		mtm6417
orthoMCL	1	0.900	-	-		OOG6_103097
Panther	1	1.100	-	-	O	PTHR16160
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X911
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.760