DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fit2 and Fit1

DIOPT Version :9

Sequence 1:	NP_648947.1	Gene:	Fit2 / 39907	FlyBaseID:	FBgn0036688	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_647858.2	Gene:	Fit1 / 38488	FlyBaseID:	FBgn0035498	Length:	708	Species:	Drosophila melanogaster

Alignment Length:	716	Identity:	541/716 - (75%)
Similarity:	624/716 - (87%)	Gaps:	9/716 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIHVGENSWNLRIFITDLALEKTMRVRGDQHIGGIMLQLVDPENPKDWSDHALWWPARNVWLSRT 65
            |||||||:|||||.||||.:|||:||:|||||||:||.|||||.|||||||||||||:|:||:||
  Fly     1 MIHVGENTWNLRILITDLQVEKTLRVKGDQHIGGVMLNLVDPELPKDWSDHALWWPAKNIWLTRT 65

  Fly    66 KLTLDQCGVQADSLLHFTPMHKILRVQLPDLRYLDSRVDYSVKTFSAVVNLCKQLDIRYPEELSL 130
            :.||||.|||:||.||||||||.||||:|||||||.||::|.|||.|||:|||.||||||||||.
  Fly    66 RSTLDQAGVQSDSFLHFTPMHKTLRVQMPDLRYLDYRVNFSAKTFGAVVSLCKDLDIRYPEELSF 130

  Fly   131 CKPLEAEHLKRNFAQVPHQKRVPIAEPDGTTYLQPAADTNSFVPISTSFHGEGGSTGSLDKPSAP 195
            |||||.||||:||:::| |:::|:||.:|..|:|||.||||||||:.:::   ||.||||: |..
  Fly   131 CKPLEPEHLKKNFSKLP-QRKIPVAEANGIAYVQPALDTNSFVPITGAYN---GSNGSLDR-SHN 190

  Fly   196 GSFFCAPLSPHNHR-ARSPVRTVSPFPGTWKQSQLGYATYDSSSSSLGDFQENLASSPPTPCADV 259
            |:..|||.||:..| |.:|...:|...||||.:..|||:|| |:||.||.|||||.||.:|..||
  Fly   191 GNLLCAPASPYTRRAATAPGTPISSPTGTWKHNSTGYASYD-SNSSFGDLQENLAMSPRSPSPDV 254

  Fly   260 RALQLRPKSLVEKARLNVGWLDSSLSIMEQGIREYDTLCLRFKYFTFFDLNPKCDQVRINQLYEQ 324
            ||..:||||.|||||||||||||||||||||:|||||||||||||||||||||.|||||||||||
  Fly   255 RARLVRPKSRVEKARLNVGWLDSSLSIMEQGVREYDTLCLRFKYFTFFDLNPKYDQVRINQLYEQ 319

  Fly   325 AKWSVLNEELDCTEEESLMFAALQFQVNHHVDHTPQGAAVDSGIETSSQENDNEDEIDSALKELQ 389
            ||||:|||||:.||||:||||||||||||..|..|.|  :||||:|||||...||:|||||.|||
  Fly   320 AKWSILNEELEPTEEETLMFAALQFQVNHQTDLHPPG--IDSGIDTSSQETGGEDDIDSALNELQ 382

  Fly   390 ITLEGPDYGGDSRNITRIPELSDYLRYLKPQRFTLRGYKRYYFTYRDLHLHLFKNAEDSRRVAPA 454
            ||||||..|.|..||||||||||||::||||||||:|||||:||||||||||:|:.::|||.||.
  Fly   383 ITLEGPGGGKDQGNITRIPELSDYLKFLKPQRFTLKGYKRYFFTYRDLHLHLYKSQDESRRGAPT 447

  Fly   455 ISINLKGCEVTPDVNLSQGKYAIRLEVSPDGGHGINSEVWVRCENEQQYAKWMAACRLAAKGRSL 519
            ||||||||||||||||:|||:||||||..:..:|.||||||||:||:||||||||||||||||||
  Fly   448 ISINLKGCEVTPDVNLAQGKFAIRLEVPSEIRNGPNSEVWVRCDNEEQYAKWMAACRLAAKGRSL 512

  Fly   520 ADSSYESEVDSILSLLQMQRPAHGVHVNIDPRSVEAVDYLSPKIIRKLSNKAVQRILEAHANVRE 584
            |||||:|||.||.||||||:||.|..:.::|||||.:||||||::||||:||||||||||||||:
  Fly   513 ADSSYDSEVSSIRSLLQMQKPAQGAPLTVNPRSVEPMDYLSPKMMRKLSSKAVQRILEAHANVRQ 577

  Fly   585 LNALDSKLKYIQAWRSLPDFGVSLFIIKFDGHRKEELLGVAHNRIMRMDLSSGDHIKTWRYNTMK 649
            |:.:|:|:||||||:|||||||:|||||||||:||||||||:||||||||::|||||||||||||
  Fly   578 LSLMDAKMKYIQAWQSLPDFGVTLFIIKFDGHKKEELLGVANNRIMRMDLNTGDHIKTWRYNTMK 642

  Fly   650 AWNVNWNIKCMMIQFEDENVVFSCHSADCKVVHEFIGGYIFMSMRSKDTNQTLNEELFHKLTGGW 714
            ||||||.|||||||.:|||:|||..||||||||||||||||||||||:.|||||||:||||||||
  Fly   643 AWNVNWGIKCMMIQLQDENIVFSVQSADCKVVHEFIGGYIFMSMRSKENNQTLNEEMFHKLTGGW 707

  Fly   715 S 715
            |
  Fly   708 S 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fit2	NP_648947.1	B41	259..>351	CDD:214604	81/91 (89%)
		FERM_M	310..>365	CDD:278785	42/54 (78%)
		PH_fermitin	408..536	CDD:269943	102/127 (80%)
		PH	408..515	CDD:278594	84/106 (79%)
		FERM_M	<557..609	CDD:278785	40/51 (78%)
		FERM_C_fermitin	603..693	CDD:270026	78/89 (88%)
Fit1	NP_647858.2	FERM_B-lobe	305..>348	CDD:298919	37/42 (88%)
		PH_fermitin	401..529	CDD:269943	102/127 (80%)
		PH	401..508	CDD:278594	84/106 (79%)
		FERM_M	<538..602	CDD:278785	45/63 (71%)
		FERM_C_fermitin	596..686	CDD:270026	78/89 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463707
Domainoid	1	1.000	297	1.000	Domainoid score	I1426
eggNOG	1	0.900	-	-		E1_KOG3727
Homologene	1	1.000	-	-		H4976
Inparanoid	1	1.050	630	1.000	Inparanoid score	I825
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48345
OrthoDB	1	1.010	-	-		D132272at33208
OrthoFinder	1	1.000	-	-		FOG0001455
OrthoInspector	1	1.000	-	-		mtm6417
orthoMCL	1	0.900	-	-		OOG6_103097
Panther	1	1.100	-	-	P	PTHR16160
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X911
	13	12.810