DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fit2 and ptpn4a

DIOPT Version :9

Sequence 1:	NP_648947.1	Gene:	Fit2 / 39907	FlyBaseID:	FBgn0036688	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_001007201.1	Gene:	ptpn4a / 368448	ZFINID:	ZDB-GENE-030616-449	Length:	921	Species:	Danio rerio

Alignment Length:	416	Identity:	95/416 - (22%)
Similarity:	138/416 - (33%)	Gaps:	126/416 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 QADSL-LHFTPMHKILRVQLPDLRYLDSRVDYSVKTFSAVVNLCKQLDIRYPEELSLCKPLEAEH 138
            ||:|: |..||..:.:....|.|....||     |..|.::....|.|:..........|...:.
Zfish   442 QANSISLESTPSPEGVEGPPPALPPKQSR-----KNLSQLILSHSQQDLDNHINEMYDVPTATDK 501

  Fly   139 LKRNFAQVPHQKRVPI-AEPDGTTYLQPAADTNSFVPISTSFHGEGGSTGSLD---KPSAPGSF- 198
            :..| ..|||...|.| .:||         :...|     .|:.:|||...:.   ...|||:.
Zfish   502 VMPN-GVVPHDNLVLIKMKPD---------ENGRF-----GFNVKGGSDQKMPIIVSRVAPGTSA 551

  Fly   199 -FCAP---------------LSPHNHRARSPVRTVSPFPGTWKQSQLG--------YATYDSSSS 239
             .|.|               ::.|:|      ..|..|.....:|..|        .|.||....
Zfish   552 DLCVPRLNEGDQVVLINGREIAEHSH------DQVVMFIKASCESHSGELILLVRPNAIYDVVEE 610

  Fly   240 SL---GDFQENLASSPPTPCADVRALQLRPKSLVEKARLNVGWLDSSLSIME---QG--IREYDT 296
            .|   .|||.....||..           |..|.:.|     |.||.|.:.|   .|  :.::|.
Zfish   611 KLETEPDFQYIPEKSPTD-----------PSHLDQDA-----WRDSMLYLKEGLNSGTILAQFDQ 659

  Fly   297 LCLRFKYFT--------------FFDLNP--------KCDQVRINQLY---EQAKWSVLNEELDC 336
            |..:....|              :.|::|        |..:..||..|   |....|::|..:.|
Zfish   660 LYRKRPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGTEDYINANYINMEIPACSLINRYIAC 724

  Fly   337 T---------------EEESLMFAALQFQVN-HHVDHTPQGAAVDSGIETSSQENDNEDEIDSAL 385
            .               |:.|.|...|..||. |.....|.|:|...|.:.|.|    .:|.:||.
Zfish   725 QGPLPNTCSDFWQMTWEQGSSMVVMLTTQVKCHQYWPNPSGSATYGGFQISCQ----TEEGNSAF 785

  Fly   386 KELQITLEGPDYGGDSRNITRIPELS 411
            ...:|||...: .|:||.:|:|..|:
Zfish   786 LVREITLTHIE-SGESRELTQIQYLA 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fit2	NP_648947.1	B41	259..>351	CDD:214604	26/136 (19%)
		FERM_M	310..>365	CDD:278785	19/81 (23%)
		PH_fermitin	408..536	CDD:269943	1/4 (25%)
		PH	408..515	CDD:278594	1/4 (25%)
		FERM_M	<557..609	CDD:278785
		FERM_C_fermitin	603..693	CDD:270026
ptpn4a	NP_001007201.1	B41	30..222	CDD:214604
		FERM_N	33..97	CDD:286467
		FERM_B-lobe	122..214	CDD:271216
		FERM_C_PTPN4_PTPN3_like	216..310	CDD:270010
		FA	325..364	CDD:285894
		PDZ_signaling	513..600	CDD:238492	20/106 (19%)
		PTPc	653..903	CDD:214550	38/163 (23%)
		PTPc	680..902	CDD:238006	35/136 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910