DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fit2 and Fermt3

DIOPT Version :9

Sequence 1:	NP_648947.1	Gene:	Fit2 / 39907	FlyBaseID:	FBgn0036688	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_001121015.1	Gene:	Fermt3 / 309186	RGDID:	1310168	Length:	665	Species:	Rattus norvegicus

Alignment Length:	728	Identity:	296/728 - (40%)
Similarity:	435/728 - (59%)	Gaps:	99/728 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ENSWNLRIFITD---LALEKTMRVRGDQHIGGIMLQLVDPENPK-DWSDHALWWPARNVWLSRTK 66
            ::||.||:|:.:   .|...|:||.|:.||||::|::|:..|.| ||||||:||..:..||.:|.
  Rat    13 DSSWELRVFVGEEDPEAQSVTLRVTGESHIGGVLLKIVEEINRKQDWSDHAIWWEQKKQWLLQTH 77

  Fly    67 LTLDQCGVQADSLLHFTPMHKILRVQLPDLRYLDSRVDYSVKTFSAVVNLCKQLDIRYPEELSLC 131
            .|||:.|:.||:.|.|.|.|:.:.::||:.|.|..|..:|...|..|..:|:.|.||:||||||.
  Rat    78 WTLDKYGILADARLFFGPQHRPVILRLPNRRVLRLRASFSKPLFQTVAAICRLLSIRHPEELSLL 142

  Fly   132 KPLEAEHLKRNFAQVPHQKRVPIAEPDGTTYLQPAADTNSFVPISTSFHGEGGSTGSLDKPSAPG 196
            :..|.:..|:       :::.|..|....|.:..|...     ..|.|.|
  Rat   143 RAPEKKEKKK-------KEKEPEEEVHDLTRVVLAGGV-----APTLFRG--------------- 180

  Fly   197 SFFCAPLSPHNHRARSPVRTVSPFPGTWKQSQLGYATYDSSSSSLGDFQENLASSPPTPCADVRA 261
                                   .|..:..|....|.|...|.             |.|..|...
  Rat   181 -----------------------MPAHFSDSAQTEACYHMLSR-------------PQPAPDPLL 209

  Fly   262 LQL--RPKSLVEKARLNVGWLDSSLSIMEQGIREYDTLCLRFKYFTFFDLNPKCDQVRINQLYEQ 324
            ||.  ||.||::|.:|:..|||||..:|:|||:..|.|.|||||::||||:||.|.||:.|||||
  Rat   210 LQRLPRPSSLLDKTQLHSRWLDSSRCLMQQGIKAGDVLWLRFKYYSFFDLDPKTDPVRLTQLYEQ 274

  Fly   325 AKWSVLNEELDCTEEESLMFAALQFQVNHHVDHTPQG--AAVDSGIETSSQENDNEDEIDSALKE 387
            |:|.:|.||:||||||.::|||||:.:|........|  |:.|.|:          |::|:||..
  Rat   275 ARWDLLTEEIDCTEEEMMVFAALQYHINKVTLSGDVGELASGDPGL----------DDLDAALNN 329

  Fly   388 LQITLEGPDYGGDSRNITRIPELSDYLRYLKPQRFTLRGYKRYYFTYRDLHLHLFKNAEDSRRVA 452
            |::.|:|........::|.||||.|:||..:|::.||:||::::..::|..|..:| ::|.....
  Rat   330 LEVKLKGSAPSDMLDSLTTIPELKDHLRIFRPRKLTLKGYRQHWVIFKDTTLSYYK-SQDEAPGD 393

  Fly   453 PAISINLKGCEVTPDVNLSQGKYAIRLEV-SPDGGHGINSEVWVRCENEQQYAKWMAACRLAAKG 516
            |...:|||||||.||||:|..|:.|:|.| ||:|    .||:::||::|||||:||||||||:||
  Rat   394 PIQQLNLKGCEVVPDVNVSGQKFCIKLLVPSPEG----MSEIYLRCQDEQQYAQWMAACRLASKG 454

  Fly   517 RSLADSSYESEVDSILSLLQMQRP--AHGVHVNIDPRSVEA-------VDYLSPKIIRKLSNKAV 572
            |::|||||.|||.:||:.|.:||.  .:|...| .|:.:||       ...::|:..||...|.:
  Rat   455 RTMADSSYASEVQAILAFLSLQRAGGTNGGSGN-KPQGLEASAEGLNPYGLVAPRFQRKFKAKQL 518

  Fly   573 -QRILEAHANVRELNALDSKLKYIQAWRSLPDFGVSLFIIKFDGHRKEELLGVAHNRIMRMDLSS 636
             .||||||.||.:|:..:::|::||||:||||||:|..|::|.|.||:|:||:|:||::|:||:.
  Rat   519 TPRILEAHQNVAQLSLTEAQLRFIQAWQSLPDFGISYVIVRFKGSRKDEILGIANNRLIRIDLAV 583

  Fly   637 GDHIKTWRYNTMKAWNVNWNIKCMMIQFEDE-NVVFSCHSADCKVVHEFIGGYIFMSMRSKDTNQ 700
            ||.:||||::.|:.|||||:|:.:.|:|::. ||.|||.||.|::|||:||||||:|.|.:...:
  Rat   584 GDVVKTWRFSNMRQWNVNWDIRQVAIEFDEHINVAFSCVSASCRIVHEYIGGYIFLSTRERARGE 648

  Fly   701 TLNEELFHKLTGG 713
            .|:|:||.:||||
  Rat   649 ELDEDLFLQLTGG 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fit2	NP_648947.1	B41	259..>351	CDD:214604	54/93 (58%)
		FERM_M	310..>365	CDD:278785	29/56 (52%)
		PH_fermitin	408..536	CDD:269943	65/128 (51%)
		PH	408..515	CDD:278594	52/107 (49%)
		FERM_M	<557..609	CDD:278785	25/52 (48%)
		FERM_C_fermitin	603..693	CDD:270026	50/90 (56%)
Fermt3	NP_001121015.1	Ubiquitin_like_fold	15..97	CDD:421700	38/81 (47%)
		FERM_F1_KIND3	98..254	CDD:340705	58/218 (27%)
		B41	<221..>301	CDD:214604	48/79 (61%)
		PH_fermitin	350..474	CDD:269943	65/128 (51%)
		FERM_M	462..555	CDD:395297	38/93 (41%)
		FERM_C_fermitin	550..641	CDD:270026	50/90 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350297
Domainoid	1	1.000	290	1.000	Domainoid score	I1485
eggNOG	1	0.900	-	-		E1_KOG3727
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	625	1.000	Inparanoid score	I826
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132272at33208
OrthoFinder	1	1.000	-	-		FOG0001455
OrthoInspector	1	1.000	-	-		mtm9058
orthoMCL	1	0.900	-	-		OOG6_103097
Panther	1	1.100	-	-	O	PTHR16160
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X911
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760