DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fit2 and Fermt1

DIOPT Version :9

Sequence 1:	NP_648947.1	Gene:	Fit2 / 39907	FlyBaseID:	FBgn0036688	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_001099985.1	Gene:	Fermt1 / 296179	RGDID:	1306816	Length:	677	Species:	Rattus norvegicus

Alignment Length:	729	Identity:	319/729 - (43%)
Similarity:	464/729 - (63%)	Gaps:	87/729 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SWNLRIFITDLALEK-----TMRVRGDQHIGGIMLQLVDPEN-PKDWSDHALWWPARNVWLSRTK 66
            ||.|.:.: |.|.|:     |:||.||.||||:||:||:..| .:||||.||||..:..||.:|.
  Rat    11 SWELVVRV-DHANEEQQTDITLRVSGDLHIGGVMLKLVEQMNIAQDWSDFALWWEQKRCWLLKTH 74

  Fly    67 LTLDQCGVQADSLLHFTPMHKILRVQLPDLRYLDSRVDYSVKTFSAVVNLCKQLDIRYPEELSLC 131
            .|||:||||||:.|.|||.||:||::||:.|.:..||.:|...|.||.::||.|:||.||||||.
  Rat    75 WTLDKCGVQADAKLLFTPQHKMLRLRLPNTRTVRLRVSFSAVVFKAVADICKVLNIRRPEELSLL 139

  Fly   132 KPLEAEHLKRNFAQVPHQKRVPIAEPDGTTYLQPAADTNSFVPISTSFHGEGGSTGSLDKPSAPG 196
            || ..::.|:.      :|:                :.||..|:.........|:.|...|.:||
  Rat   140 KP-SGDYCKKK------KKK----------------EKNSKEPVIEDILNLESSSTSSGSPVSPG 181

  Fly   197 SFFCAPLSPHNHRARSPVRTVSPFPGTWKQSQLGYATYDSSSSSLGD---FQEN---LASSPPTP 255
            .:           :::...|..|..||...|.:.:         .||   .::|   ||.|.|.|
  Rat   182 LY-----------SKTMTPTYDPINGTPALSTMTW---------FGDSPLTEQNCSVLAFSQPPP 226

  Fly   256 CADVRALQLRPKSLVEKARLNVGWLDSSLSIMEQGIREYDTLCLRFKYFTFFDLNPKCDQVRINQ 320
            ..:|.|...:|:|||:||::|.||||||.|:|||.|:|.:.|.|||||:||||||||.|.|||||
  Rat   227 SPEVLAEMFQPRSLVDKAKMNAGWLDSSRSLMEQSIQEDEQLLLRFKYYTFFDLNPKYDAVRINQ 291

  Fly   321 LYEQAKWSVLNEELDCTEEESLMFAALQFQVNHHVDHTPQGAAVDSGIETSSQENDNEDEIDSAL 385
            |||||:|:||.||:||||||.|:|||||:    |:......|.:.. ..|.|:    .||:::||
  Rat   292 LYEQARWAVLLEEIDCTEEEMLIFAALQY----HISKLSLCAEIQD-FATKSE----VDEVEAAL 347

  Fly   386 KELQITLEGPDYGGDSRNITRIPELSDYLRYLKPQRFTLRGYKRYYFTYRDLHLHLFKNAEDSRR 450
            ..|::||||........:||.||:|:|||:..||::..|:.:|:|:|.::|..:..||| ::..:
  Rat   348 SSLEVTLEGGKADNTLEDITDIPKLADYLKLFKPKKLMLKAFKQYWFVFKDTSIAYFKN-QELEQ 411

  Fly   451 VAPAISINLKGCEVTPDVNLSQGKYAIRLEVSPDGGHGINSEVWVRCENEQQYAKWMAACRLAAK 515
            ..|...:|::|||:.||||::..|:.|:|.:..  ..|:| ||::||::|.|||:|||||.||:|
  Rat   412 GEPIEKLNIRGCEIVPDVNVAGRKFGIKLLIPV--ADGMN-EVYLRCDHEDQYARWMAACILASK 473

  Fly   516 GRSLADSSYESEVDSILSLLQMQRPAHGVHVNIDP---RSVEAVD-----YLSPKIIRKLSNKAV 572
            |:::|||||:.||.||||.|:|:      :.|..|   .|:|::|     .:||:..:|..:|.:
  Rat   474 GKTMADSSYQPEVVSILSFLKMK------NRNSSPLVASSLESMDMNPECLVSPRCAKKHKSKQL 532

  Fly   573 -QRILEAHANVRELNALDSKLKYIQAWRSLPDFGVSLFIIKFDGHRKEELLGVAHNRIMRMDLSS 636
             .||||||.||.::..:::||::||||:|||:||::.::::|.|.:|:::|||::||::|||..:
  Rat   533 AARILEAHHNVAQMPLVEAKLQFIQAWQSLPEFGLTYYLVRFKGSKKDDILGVSYNRLIRMDAVT 597

  Fly   637 GDHIKTWRYNTMKAWNVNWNIKCMMIQFEDENV--VFSCHSADCKVVHEFIGGYIFMSMRSKDTN 699
            |..:.|||:..||.|||||.|:.:.|:| |:||  .|:|.||.||:|||:||||||:|.||||.|
  Rat   598 GIPVTTWRFANMKQWNVNWEIRQVAIEF-DQNVSIAFTCLSAGCKIVHEYIGGYIFLSTRSKDQN 661

  Fly   700 QTLNEELFHKLTGG 713
            :||:|:||||||||
  Rat   662 ETLDEDLFHKLTGG 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fit2	NP_648947.1	B41	259..>351	CDD:214604	63/91 (69%)
		FERM_M	310..>365	CDD:278785	33/54 (61%)
		PH_fermitin	408..536	CDD:269943	57/127 (45%)
		PH	408..515	CDD:278594	44/106 (42%)
		FERM_M	<557..609	CDD:278785	24/57 (42%)
		FERM_C_fermitin	603..693	CDD:270026	45/91 (49%)
Fermt1	NP_001099985.1	B41	<250..>322	CDD:214604	53/75 (71%)
		FERM_M	281..>322	CDD:278785	31/44 (70%)
		PH_fermitin	370..494	CDD:269943	57/127 (45%)
		PH	378..473	CDD:278594	39/98 (40%)
		FERM_M	<515..570	CDD:278785	23/54 (43%)
		FERM_C_fermitin	564..655	CDD:270026	45/91 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350295
Domainoid	1	1.000	290	1.000	Domainoid score	I1485
eggNOG	1	0.900	-	-		E1_KOG3727
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	625	1.000	Inparanoid score	I826
OMA	1	1.010	-	-		QHG48345
OrthoDB	1	1.010	-	-		D132272at33208
OrthoFinder	1	1.000	-	-		FOG0001455
OrthoInspector	1	1.000	-	-		mtm9058
orthoMCL	1	0.900	-	-		OOG6_103097
Panther	1	1.100	-	-	O	PTHR16160
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X911
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770