DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fit2 and Frmd3

DIOPT Version :9

Sequence 1:	NP_648947.1	Gene:	Fit2 / 39907	FlyBaseID:	FBgn0036688	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_766457.1	Gene:	Frmd3 / 242506	MGIID:	2442466	Length:	595	Species:	Mus musculus

Alignment Length:	345	Identity:	64/345 - (18%)
Similarity:	117/345 - (33%)	Gaps:	90/345 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 SLVEKARLNV---------GWLDSSLSIMEQGIREYD--TLCLRFKYFTFFDLNPKCDQVRINQL 321
            ||:||....:         .||:.:.||.:| ::.:.  |:|.|.|::....|..|.:..|. .|
Mouse    66 SLLEKDYFGIRYVDPEKQRHWLEPNKSIFKQ-MKSHPPYTMCFRVKFYPHEPLKIKEELTRY-LL 128

  Fly   322 YEQAKWSVLNEELDCTEEESLMFAALQFQV---NHHVDHTPQGAAVDSGIETSSQENDNEDEIDS 383
            |.|.|..:.:..|.|:..::....|...|.   :::.|..|:....:..|.....:.
Mouse   129 YLQIKRDIFHGRLLCSFSDAAYLGACIVQAEFGDYYPDEHPENYISEFEIFPKQSQK-------- 185

  Fly   384 ALKELQITLEGPDYGGDSRNITRIPELSDYLRYLKPQRFTLRGYKRYYFTYRDLHLHLFKNAEDS 448
             |:...:.:...:..|.|      |.::::...||.......|.        |.|     ..:||
Mouse   186 -LERKIMEIHNNELRGQS------PAIAEFNLLLKAHTLETYGV--------DPH-----PCKDS 230

  Fly   449 RRVAPAISINLKGCEVTPDVNLSQGKYAIRLEVSPDGGHGINSEVWVRCENEQQYAKWMAACRLA 513
            |.....:.....|..|      .||...|.|.                        ||...|:|.
Mouse   231 RGATAFLGFTAAGFVV------FQGNKRIHLR------------------------KWSDVCKLK 265

  Fly   514 AKGRSLADSSYESEVDSILSLLQMQRPAHGVHV---NID-------PRSVEAVDYLSPKIIRK-- 566
            .:|::......:.|.:::|: .....||...|:   .::       .:|.:.....|.||..|
Mouse   266 FEGKTFYVIGSQKEKNAVLA-FHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFFKGS 329

  Fly   567 ---LSNKAVQRILEAHANVR 583
               .|.|..:.::||.:.::
Mouse   330 RFRYSGKVAKEVVEASSKIQ 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fit2	NP_648947.1	B41	259..>351	CDD:214604	23/93 (25%)
		FERM_M	310..>365	CDD:278785	12/57 (21%)
		PH_fermitin	408..536	CDD:269943	22/127 (17%)
		PH	408..515	CDD:278594	19/106 (18%)
		FERM_M	<557..609	CDD:278785	8/32 (25%)
		FERM_C_fermitin	603..693	CDD:270026
Frmd3	NP_766457.1	B41	33..225	CDD:214604	35/183 (19%)
		FERM_N	36..99	CDD:286467	9/33 (27%)
		FERM_M	117..225	CDD:278785	22/131 (17%)
		PH-like	206..309	CDD:302622	24/146 (16%)
		FA	323..>357	CDD:285894	7/27 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910